IUPHAR Review: Eating Disorders, Gut Microbiota Dysbiosis and Epigenetic Aberrations DOI Creative Commons
Shabnam Nohesara, Hamid M. Abdolmaleky, Giuseppe Pettinato

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107653 - 107653

Published: Feb. 17, 2025

Eating disorders (EDs) are a heterogeneous class of increasing mental that characterized by disturbances in eating behaviors, body weight regulation, and associated psychological dysfunctions. These create physiological imbalances alter the diversity composition gut microbiota. While evidence suggests EDs can arise from epigenetic aberrations, alterations microbial communities may also contribute to development and/or persistence through mechanisms. Understanding interplay among communities, processes, risk provides opportunities for designing preventive therapeutic interventions microbiome modulation. This review highlights how microbiome-based therapeutics specific dietary improving various subtypes modulating mitigating aberrations. First, we briefly literature on links between aberrations pathophysiology EDs. Second, examine potential role pathogenesis Next, explore associations other psychiatric disorders, roles their pathogenesis. Finally, present supporting improve modifications.

Language: Английский

Hunger Games: A Modern Battle Between Stress and Appetite DOI Open Access

W. G. Smith,

Estefania P. Azevedo

Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(2)

Published: Feb. 1, 2025

ABSTRACT Stress, an evolutionarily adaptive mechanism, has become a pervasive challenge in modern life, significantly impacting feeding‐relevant circuits that play role the development and pathogenesis of eating disorders (EDs). Stress activates hypothalamic–pituitary–adrenal (HPA) axis, disrupts specific neural circuits, dysregulates key brain regions, including hypothalamus, hippocampus, lateral septum. These particular structures are interconnected integrating stress feeding signals, modulating hunger, satiety, cognition, emotional coping behaviors. Here we discuss interplay between genetic predispositions environmental factors may exacerbate ED vulnerability. We also highlight most commonly used animal models to study mechanisms driving EDs recent rodent studies emphasize discovery novel cellular molecular signals within hippocampus–lateral septum–hypothalamus axis. In this review, gut microbiome, emerging area research field unanswered questions persist hinder scientific progress, such as why some individuals remain resilient while others at high risk for EDs. finally need future delineating impact stressors on clarifying relevance functionality hippocampal–septal–hypothalamic connectivity, investigating neuropeptides CRH, oxytocin, GLP‐1 human pathogenesis. Emerging tools like single‐cell sequencing advanced imaging could uncover circuit‐level changes areas relevant patients. Ultimately, by basic clinical research, science offers promising avenues developing personalized, mechanism‐based treatments targeting maladaptive behavior patients suffering from image

Language: Английский

Citations

0
IUPHAR Review: Eating Disorders, Gut Microbiota Dysbiosis and Epigenetic Aberrations DOI Creative Commons
Shabnam Nohesara, Hamid M. Abdolmaleky, Giuseppe Pettinato

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 213, P. 107653 - 107653

Published: Feb. 17, 2025

Eating disorders (EDs) are a heterogeneous class of increasing mental that characterized by disturbances in eating behaviors, body weight regulation, and associated psychological dysfunctions. These create physiological imbalances alter the diversity composition gut microbiota. While evidence suggests EDs can arise from epigenetic aberrations, alterations microbial communities may also contribute to development and/or persistence through mechanisms. Understanding interplay among communities, processes, risk provides opportunities for designing preventive therapeutic interventions microbiome modulation. This review highlights how microbiome-based therapeutics specific dietary improving various subtypes modulating mitigating aberrations. First, we briefly literature on links between aberrations pathophysiology EDs. Second, examine potential role pathogenesis Next, explore associations other psychiatric disorders, roles their pathogenesis. Finally, present supporting improve modifications.

Language: Английский

Citations

0