The effects of costly telomere maintenance on lifespan - reproductive tradeoffs in sand lizards DOI Creative Commons
Mats Olsson, Emily Miller, Nicky Rollings

et al.

Evolution, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Telomeres are DNA-protein structures that primarily protect chromosomes and serve multiple functions of gene regulation. When cells divide, telomeres shorten their main repair system in ectotherms - telomerase – replaces lost nucleotide complexes ((T2AG3)n vertebrates). It remains a challenge to experimentally investigate resource requirements for telomere maintenance its effects on lifespan-reproductive tradeoffs the wild. In sand lizards (Lacerta agilis), we show higher female investments into reproduction results corresponding shortening males have less frequent profound than females; contributing factor this may be males’ levels. To manipulate access maintenance, exploit pseudo-experimental opportunity analyze ‘onboard’ resources long-term using drop tails with fat nutrient deposits when attacked by predators. Females due regrown often profoundly elongate telomeres. Adult most TL elongation live longest, females highest lifetime reproductive success most, whereas success. This suggests ongoing evolution resource-constrained maintenance.

Language: Английский

Immune response accelerated telomere shortening during early life stage of a passerine bird, the blue tit ( Cyanistes caeruleus ) DOI Creative Commons
Matteo Schiavinato, Shivani Ronanki,

Ignacio Miro Estruch

et al.

Biology Letters, Journal Year: 2025, Volume and Issue: 21(1)

Published: Jan. 1, 2025

Dealing with infections is a daily challenge for wild animals. Empirical data show an increase in reactive oxygen species (ROS) production during immune response. This could have consequences on telomere length, the end parts of linear chromosomes, commonly used as proxy good health and ageing. Telomere length dynamics may reflect costs associated physiological responses. In this study, system blue tit ( Cyanistes caeruleus ) nestlings was experimentally challenged through polyinosinic:polycytidylic acid (poly I:C) injection, synthetic double-stranded RNA that mimics virus, activating pathway response triggered via toll-like receptors 3. path known to form ROS downstream. Immune quantified by white cell counts blood, while brain lipoperoxidation has been evaluated indicator oxidative damage. Finally, individuals’ shortening between days 8 15 after hatching measured erythrocytes. Challenged showed increased leukocyte number when compared control (treated saline solution), lower lipid peroxidation (likely result compensatory mechanism stress burst) accelerated shortening. These findings support ‘ageing cost pathway’ hypothesis, which supposes role quick biological

Language: Английский

Citations

0
Food deprivation is associated with telomere elongation during hibernation in a primate DOI
Marina B. Blanco, Dana L. Smith, Lydia K. Greene

et al.

Biology Letters, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

Telomeres, the protective ends of chromosomes, progressively shorten due to incomplete mitotic replication and oxidative stress. In some organisms, transient telomere elongation may occur, for example, when individuals have an energy surplus counter stress-induced life events or elongating telomeres is a last chance increase fitness. Mammalian hibernators are good models test dynamics, as they cycle between prolonged bouts metabolic depression (torpor) punctuated by short surges euthermia (arousals). We studied captive fat-tailed dwarf lemurs ( Cheirogaleus medius ), strepsirrhine primate hibernators, that were food-deprived n = 8) fed daily 7) during hibernation (4.5 months). compared lengths, assayed via qPCR from oral swabs, at five strategic time points span full year. Food-deprived subjects underwent multi-day torpor/arousal cycles, lost considerable body mass elongated but shortened them upon emergence. contrast, food-provisioned ate daily, more slowly, shallower shorter torpor experienced little change in lengths same periods. Our results highlight complex relationship balance expression. Further investigation warranted elucidate regulation mechanisms these hibernators.

Language: Английский

Citations

0
Why and when should organisms elongate their telomeres? Elaborations on the ‘excess resources elongation’ and ‘last resort elongation’ hypotheses DOI Creative Commons
David Gómez‐Blanco, Michael Tobler, Dennis Hasselquist

et al.

Ecology and Evolution, Journal Year: 2023, Volume and Issue: 13(12)

Published: Dec. 1, 2023

Telomere length and telomere shortening are thought to be critical cellular attributes processes that related an individual's life span fitness. The general pattern across most taxa is after birth gradually decreases with age. protection restoration mechanisms usually assumed reduce the rate of or at keep constant. However, here we have compiled a list 26 articles showing there increasing number studies reporting apparent elongation telomeres (i.e., net increase in TL from time

Language: Английский

Citations

6
The association between age and telomere length is age‐dependent: Evidence for a threshold model of telomere length maintenance DOI Creative Commons
Ana Á. Romero‐Haro, G. Mulder, Mark F. Haussmann

et al.

Journal of Experimental Zoology Part A Ecological and Integrative Physiology, Journal Year: 2024, Volume and Issue: 341(4), P. 338 - 344

Published: Jan. 22, 2024

Abstract Telomere length and dynamics are commonly used biomarkers of somatic state, yet the role telomeres underlying aging process is still debated. Indeed, to date, empirical evidence for an association between age telomere mixed. Here, we test if age‐dependency can provide a potential explanation reported inconsistencies across studies. To this end, quantified by restriction fragment analysis in two groups Japanese quail ( Coturnix japonica ) that differed their distribution. One group consisted young adults only, whereas second wide range ages. In group, there was highly significant negative age, no found all‐ages group. This difference not due length‐dependent selective disappearance. Our results shows age‐dependent suggest costs benefits associated with maintenance dynamic individual's life course.

Language: Английский

Citations

0
From cells to recapture rates: responses and recovery of a wild fish after an experimental exposure to a widely used herbicide DOI
Aurélie Goutte, Nicolas Martin, Fabrice Alliot

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Language: Английский

Citations

0
The effects of costly telomere maintenance on lifespan - reproductive tradeoffs in sand lizards DOI Creative Commons
Mats Olsson, Emily Miller, Nicky Rollings

et al.

Evolution, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Telomeres are DNA-protein structures that primarily protect chromosomes and serve multiple functions of gene regulation. When cells divide, telomeres shorten their main repair system in ectotherms - telomerase – replaces lost nucleotide complexes ((T2AG3)n vertebrates). It remains a challenge to experimentally investigate resource requirements for telomere maintenance its effects on lifespan-reproductive tradeoffs the wild. In sand lizards (Lacerta agilis), we show higher female investments into reproduction results corresponding shortening males have less frequent profound than females; contributing factor this may be males’ levels. To manipulate access maintenance, exploit pseudo-experimental opportunity analyze ‘onboard’ resources long-term using drop tails with fat nutrient deposits when attacked by predators. Females due regrown often profoundly elongate telomeres. Adult most TL elongation live longest, females highest lifetime reproductive success most, whereas success. This suggests ongoing evolution resource-constrained maintenance.

Language: Английский

Citations

0