Effect of developmental and adult diet composition on reproductive aging in Drosophila melanogaster DOI Creative Commons
B G Ruchitha,

Devashish Kumar,

M V Chandrakanth

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 194, P. 112501 - 112501

Published: June 18, 2024

Diet significantly affects reproductive outcomes across species, yet the precise effects of macronutrient compositions beyond caloric intake on aging are understudied. Existing literature presents conflicting views fertility impacts nutrient-rich versus nutrient-poor developmental diets, underscoring a notable research gap. This study addresses these gaps by examining isocaloric diets with varied protein-to-carbohydrate ratios during both and adult stages large, outbred Drosophila melanogaster population (n = ∼2100). Our results clearly demonstrate an age-dependent dietary impact output, initially dominated diet, then combination in early to mid-life, ultimately diet later life. Importantly, we found that output independent, no significant interaction. Further investigations into mechanisms revealed effect fecundity is regulated via ovarioles formation vitellogenesis; while, mostly only vitellogenesis. These insights resolve disputes about offer valuable perspectives for optimizing strategies improving public health conservation efforts this changing world.

Language: Английский

Diet‐induced plasticity of life‐history traits and gene expression in outbred Drosophila melanogaster population DOI Creative Commons
Akhila Mudunuri,

M V Chandrakanth,

Soumen Khan

et al.

Ecology and Evolution, Journal Year: 2024, Volume and Issue: 14(2)

Published: Feb. 1, 2024

Food is fundamental for the survival of organisms, governing growth, maintenance, and reproduction through provision essential macronutrients. However, access to food with optimum macronutrient composition, which will maximize evolutionary fitness an organism, not always guaranteed. This leads dietary mismatches potential impacts on organismal performance. To understand consequences such mismatches, we examined effects isocaloric diets varying in composition eight key traits spanning across lifespan a large outbred

Language: Английский

Citations

5
Different Long-Term Nutritional Regimens of Drosophila melanogaster Shape Its Microbiota and Associated Metabolic Activity in a Sex-Specific Manner DOI Creative Commons

Repac Jelena,

Trajković Jelena,

Rakić Marija

et al.

Insects, Journal Year: 2025, Volume and Issue: 16(2), P. 141 - 141

Published: Feb. 1, 2025

The dietary habits of fruit flies profoundly influence their fitness, morphology, and physiology yet the mechanisms underlying these effects remain incompletely understood. To address this gap, relationship between regimens composition function adult Drosophila melanogaster microbiota was investigated in present study. fly communities that were reared for long time on five different diets characterized by means 16S rRNA sequencing. Obtained results revealed distinct community structures associated with each regimen, which additionally corroborated through machine learning-based analysis. In general, sugar-rich correlate microbial ecosystems higher richness/diversity. Dominance phyla Proteobacteria Firmicutes confirmed irrespective diet, varying proportions most abundant families: Acetobacteraceae, Lactobacillaceae, Moraxellaceae, Bradyrhizobiaceae, Leucostonocaceae. Bacterial families lower abundance also emerged as differentially among studied groups. Additionally, functional prediction provided initial clues into how nutrient availability might modulate metabolic traits a sex-specific manner to meet host needs. Overall, presented findings highlight intricate interplay composition, phenotype flies, underscoring importance diet determinant host-microbiota interactions.

Language: Английский

Citations

0
Personalized Research on the Aging Face—A Narrative History DOI Open Access
Marius Valeriu Hînganu,

Ramona Paula Cucu,

Delia Hînganu

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(4), P. 343 - 343

Published: March 26, 2024

Throughout history, people have struggled to find out the secret of youth. The aim manuscript is review main achievements regarding exploration aging face phenomenon. It should be very important know evolution in this field due increase life expectancy among population. Our purpose for current study serve as a starting point towards exploring novel research avenues molecular biology and confocal immunofluorescence cervicofacial soft tissues, employing cutting-edge techniques. All changes shape facial skeleton, tissue, retaining ligaments, fat compartments, skin envelope contribute varying degrees.

Language: Английский

Citations

2
Effect of developmental and adult diet composition on reproductive aging in Drosophila melanogaster DOI Creative Commons
B G Ruchitha,

Devashish Kumar,

M V Chandrakanth

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

ABSTRACT Diet significantly affects reproductive outcomes across species, yet the precise effects of macronutrient compositions beyond caloric intake on aging are understudied. Existing literature presents conflicting views fertility impacts nutrient-rich versus nutrient-poor developmental diets, underscoring a notable research gap. This study addresses these gaps by examining isocaloric diets with varied protein-to-carbohydrate ratios during both and adult stages large, outbred Drosophila melanogaster population (n = ∼2100). Our results clearly demonstrate an age-dependent dietary impact output, initially dominated diet, then combination in early to mid-life, ultimately diet later life. Importantly, we found that output independent, no significant interaction. Further investigations into mechanisms revealed effect fecundity is regulated via ovarioles formation vitellogenesis; while, mostly only vitellogenesis. These insights resolve disputes about offer valuable perspectives for optimizing strategies improving public health conservation efforts this changing world. Highlights Effect composition reproduction Developmental early-life; late-life; affect mid-life But do not interact each other regulates vitellogenesis Whereas, differential age

Language: Английский

Citations

0
Effect of developmental and adult diet composition on reproductive aging in Drosophila melanogaster DOI Creative Commons
B G Ruchitha,

Devashish Kumar,

M V Chandrakanth

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 194, P. 112501 - 112501

Published: June 18, 2024

Diet significantly affects reproductive outcomes across species, yet the precise effects of macronutrient compositions beyond caloric intake on aging are understudied. Existing literature presents conflicting views fertility impacts nutrient-rich versus nutrient-poor developmental diets, underscoring a notable research gap. This study addresses these gaps by examining isocaloric diets with varied protein-to-carbohydrate ratios during both and adult stages large, outbred Drosophila melanogaster population (n = ∼2100). Our results clearly demonstrate an age-dependent dietary impact output, initially dominated diet, then combination in early to mid-life, ultimately diet later life. Importantly, we found that output independent, no significant interaction. Further investigations into mechanisms revealed effect fecundity is regulated via ovarioles formation vitellogenesis; while, mostly only vitellogenesis. These insights resolve disputes about offer valuable perspectives for optimizing strategies improving public health conservation efforts this changing world.

Language: Английский

Citations

0