Sulfur‐π Interaction: A New Strategy for Designing NIR‐II AIE Photosensitizer for Wound Healing DOI
Haifei Wen, Ziwei Deng, Ruihua Dong

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Abstract Noncovalent interactions (NCIs) play a pivotal role in tuning the photophysical properties of functional materials, yet their potential optimizing photosensitizers remains underexplored. In this study, molecular design strategy is presented that integrates sulfur‐π (S‐π) with aggregation‐induced emission (AIE) to enhance performance near‐infrared II (NIR‐II) for biomedical applications. Unlike conventional π‐π stacking, which often leads aggregation‐caused quenching (ACQ), S‐π provide directional packing without significant fluorescence quenching. Four AIE molecules (P‐THX, T‐THX, TP‐THX, and TT‐THX) are synthesized systematic phenyl‐to‐thiophene substitution modulate precisely. These lower singlet‐triplet energy gap (Δ E ST ), extend π‐conjugation, facilitate intersystem crossing (ISC), thereby boosting generation reactive oxygen species (ROS). Single‐crystal analysis revealed create continuous electronic coupling networks advantages over stacking arrangements. The thiophene‐substituted TT‐THX exhibits superior properties, demonstrating potent photodynamic antibacterial activity against Staphylococcus aureus ( S. ) methicillin‐resistant (MRSA). When formulated as nanoparticles, enables effective wound healing, underscoring therapeutic interaction‐engineered photosensitizers. This study establishes new paradigm, unlocking advanced NIR‐II phototheranostics strategies promising applications infection treatment, cancer therapy, biosensing.

Language: Английский

Fluorination of central cores and end groups in non-fullerene acceptors for efficient organic solar cells DOI
Yaxin Zhai, Yanan Shi,

Kaiming Yang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 164193 - 164193

Published: May 1, 2025

Language: Английский

Citations

0
Sulfur‐π Interaction: A New Strategy for Designing NIR‐II AIE Photosensitizer for Wound Healing DOI
Haifei Wen, Ziwei Deng, Ruihua Dong

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Abstract Noncovalent interactions (NCIs) play a pivotal role in tuning the photophysical properties of functional materials, yet their potential optimizing photosensitizers remains underexplored. In this study, molecular design strategy is presented that integrates sulfur‐π (S‐π) with aggregation‐induced emission (AIE) to enhance performance near‐infrared II (NIR‐II) for biomedical applications. Unlike conventional π‐π stacking, which often leads aggregation‐caused quenching (ACQ), S‐π provide directional packing without significant fluorescence quenching. Four AIE molecules (P‐THX, T‐THX, TP‐THX, and TT‐THX) are synthesized systematic phenyl‐to‐thiophene substitution modulate precisely. These lower singlet‐triplet energy gap (Δ E ST ), extend π‐conjugation, facilitate intersystem crossing (ISC), thereby boosting generation reactive oxygen species (ROS). Single‐crystal analysis revealed create continuous electronic coupling networks advantages over stacking arrangements. The thiophene‐substituted TT‐THX exhibits superior properties, demonstrating potent photodynamic antibacterial activity against Staphylococcus aureus ( S. ) methicillin‐resistant (MRSA). When formulated as nanoparticles, enables effective wound healing, underscoring therapeutic interaction‐engineered photosensitizers. This study establishes new paradigm, unlocking advanced NIR‐II phototheranostics strategies promising applications infection treatment, cancer therapy, biosensing.

Language: Английский

Citations

0