Monk Fruit Extract and Sustainable Health: A PRISMA-Guided Systematic Review of Randomized Controlled Trials

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1433 - 1433

Published: April 24, 2025

Sustainable health approaches promote functional food alternatives that support metabolic well-being while reducing reliance on added sugars and artificial sweeteners. Monk fruit extract (MFE), a natural, non-caloric sweetener, is gaining interest for its potential benefits, but effects regulatory status require further evaluation. Objective: This PRISMA-guided systematic review synthesizes findings from randomized controlled trials (RCTs) assessing the impact of MFE health, lipid profiles, inflammation, considerations. Methods: The literature search was conducted across PubMed, Scopus, Web Science, Cochrane Library, covering studies published between 2015 2025. Inclusion criteria were human RCTs evaluating MFE’s effects, animal studies, reviews, mixed-intervention excluded. Study quality assessed using risk bias tool Jadad scale. Results: Five met inclusion criteria, demonstrating monk (MFE) reduces postprandial glucose levels by 10–18% insulin responses 12–22%. No severe adverse observed. Regulatory analysis indicated approved use in United States China, remains under European Union. Conclusions: shows as ingredient health. However, long-term clinical harmonized framework must confirm safety efficacy within sustainable strategies

Language: Английский

Synthetic vs. non-synthetic sweeteners: their differential effects on gut microbiome diversity and function

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

The rising use of artificial sweeteners, favored for their zero-calorie content and superior sweetness, necessitates understanding impact on the gut microbiome. This study examines effects five common sweeteners—Acesulfame K, Rebaudioside A, Saccharin, Sucralose, Xylitol—on microbiome diversity using minibioreactor arrays. Fecal samples from three healthy individuals were used to inoculate bioreactors that subsequently supplemented with each sweetener. Over 35 days, microbial network composition analyzed. Results revealed synthetic sweeteners like Sucralose Saccharin significantly reduced diversity, while non-synthetic particularly A Xylitol, less disruptive. Acesulfame K increased but disrupted structure, suggesting potential long-term negative impacts resilience. enriched pathogenic families such as Enterobacteriaceae, whereas natural promoted beneficial taxa Lachnospiraceae. Random Matrix Theory (RMT) based analysis highlighted distinct interaction patterns, causing persistent structural changes. Findings suggest may be more favorable health than ones, emphasizing cautious use, those concerns. enhances our sweeteners’ microbiome, highlighting need further research into implications.

Language: Английский