Sugarcane Molasses Polyphenol Extract Attenuates Alcohol-Induced Chronic Liver Damage via Antioxidant, Anti-Inflammatory, and CYP2E1/Keap1/NF-κB Pathway Modulation DOI Open Access
Min Wang, Lin Zhao, Yumei Wang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1589 - 1589

Published: May 5, 2025

Background/Objective: The prevention and treatment of alcoholic liver disease (ALD) urgently require safe effective nutritional intervention strategies. Polyphenol extracts from sugarcane molasses (SP) show antioxidant anti-inflammatory potential, yet their protective effects against ALD have not been elucidated. This study explored the therapeutic potential SP in alcohol-induced chronic damage. Methods: A graded alcohol concentration-induced damage model was established C57BL/6J mice to systematically evaluate SP’s regulatory on function markers, lipid metabolism, oxidative stress indicators, inflammatory factors, related molecular mechanisms through a 10-week intervention. Results: results demonstrated that significantly inhibited index, alanine aminotransferase aspartate activities, triglyceride total cholesterol accumulation mice. enhanced enzyme activities dose-dependent manner, with high-dose group increasing catalase activity by 161.19% superoxide dismutase 22.97%. Furthermore, reduced levels pro-inflammatory cytokines, including interleukin-1β, interleukin-6, tumor necrosis factor-α, thereby alleviating hepatic infiltration. Mechanistic studies revealed effectively mitigated injury inhibiting cytochrome P450 2E1 overexpression, regulating Kelch-like ECH-associated protein 1 signaling pathway, suppressing nuclear factor-kappa B pathway activation. Conclusions: findings reveal mitigates via synergistic mechanisms, providing novel strategy for high-value utilization byproducts agricultural industries. Future should focus contribution different phenolics validate specific hepatoprotective mechanisms.

Language: Английский

Sugarcane Molasses Polyphenol Extract Attenuates Alcohol-Induced Chronic Liver Damage via Antioxidant, Anti-Inflammatory, and CYP2E1/Keap1/NF-κB Pathway Modulation DOI Open Access
Min Wang, Lin Zhao, Yumei Wang

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1589 - 1589

Published: May 5, 2025

Background/Objective: The prevention and treatment of alcoholic liver disease (ALD) urgently require safe effective nutritional intervention strategies. Polyphenol extracts from sugarcane molasses (SP) show antioxidant anti-inflammatory potential, yet their protective effects against ALD have not been elucidated. This study explored the therapeutic potential SP in alcohol-induced chronic damage. Methods: A graded alcohol concentration-induced damage model was established C57BL/6J mice to systematically evaluate SP’s regulatory on function markers, lipid metabolism, oxidative stress indicators, inflammatory factors, related molecular mechanisms through a 10-week intervention. Results: results demonstrated that significantly inhibited index, alanine aminotransferase aspartate activities, triglyceride total cholesterol accumulation mice. enhanced enzyme activities dose-dependent manner, with high-dose group increasing catalase activity by 161.19% superoxide dismutase 22.97%. Furthermore, reduced levels pro-inflammatory cytokines, including interleukin-1β, interleukin-6, tumor necrosis factor-α, thereby alleviating hepatic infiltration. Mechanistic studies revealed effectively mitigated injury inhibiting cytochrome P450 2E1 overexpression, regulating Kelch-like ECH-associated protein 1 signaling pathway, suppressing nuclear factor-kappa B pathway activation. Conclusions: findings reveal mitigates via synergistic mechanisms, providing novel strategy for high-value utilization byproducts agricultural industries. Future should focus contribution different phenolics validate specific hepatoprotective mechanisms.

Language: Английский

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