Effect of astragalus injection on left ventricular remodeling in HFmrEF: a systematic review and meta-analysis DOI Creative Commons
Xu Han,

Lumei Huang,

Geng Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 6, 2024

Objectives The aim of this meta-analysis is to evaluate the effect astragalus injection (AI) on left ventricular remodeling (LVR) in patients with heart failure mildly reduced ejection fraction (HFmrEF). Methods randomized controlled trials (RCTs) AI treating HFmrEF were retrieved from 8 major English and Chinese electronic databases, up until November 30, 2023. To methodological quality included studies, Cochrane bias risk tool Modified Jadad Scale employed. Stata 17.0 software was utilized for statistical analysis, sensitivity assessment publication bias. Results Ten RCTs 995 (562 males 433 females) identified. Meta-analysis indicated that compared conventional treatment (CT), significantly improved LVR, specifically increasing (LVEF, MD = 4.56, 95% CI: 3.68–5.44, p < 0.00001), decreasing end-diastolic volume (LVEDV, −7.89, −11.13 −4.64, diameter (LVEDD, −4.18, −5.79 −2.56, end-systolic (LVESV, −8.11, −11.79 −4.43, (LVESD, −3.42, −4.90 −1.93, 0.00001). also clinical efficacy (RR 4.62, 3.11–6.88, N-terminal pro-brain natriuretic peptide (NT-pro BNP, −27.94, −43.3 −12.36) level, without incidence adverse reactions 1.60, 0.59–4.29, 0.35). Sensitivity analysis confirmed reliability merged results, Begg's Egger's tests showed no significant Conclusion systematic review revealed combining CT improves LVR events patients. However, caution needed interpreting results due limited evidence. Future high-quality are support these conclusions. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , PROSPERO [CRD42022347248].

Language: Английский

Effect of astragalus injection on left ventricular remodeling in HFmrEF: a systematic review and meta-analysis DOI Creative Commons
Xu Han,

Lumei Huang,

Geng Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 6, 2024

Objectives The aim of this meta-analysis is to evaluate the effect astragalus injection (AI) on left ventricular remodeling (LVR) in patients with heart failure mildly reduced ejection fraction (HFmrEF). Methods randomized controlled trials (RCTs) AI treating HFmrEF were retrieved from 8 major English and Chinese electronic databases, up until November 30, 2023. To methodological quality included studies, Cochrane bias risk tool Modified Jadad Scale employed. Stata 17.0 software was utilized for statistical analysis, sensitivity assessment publication bias. Results Ten RCTs 995 (562 males 433 females) identified. Meta-analysis indicated that compared conventional treatment (CT), significantly improved LVR, specifically increasing (LVEF, MD = 4.56, 95% CI: 3.68–5.44, p < 0.00001), decreasing end-diastolic volume (LVEDV, −7.89, −11.13 −4.64, diameter (LVEDD, −4.18, −5.79 −2.56, end-systolic (LVESV, −8.11, −11.79 −4.43, (LVESD, −3.42, −4.90 −1.93, 0.00001). also clinical efficacy (RR 4.62, 3.11–6.88, N-terminal pro-brain natriuretic peptide (NT-pro BNP, −27.94, −43.3 −12.36) level, without incidence adverse reactions 1.60, 0.59–4.29, 0.35). Sensitivity analysis confirmed reliability merged results, Begg's Egger's tests showed no significant Conclusion systematic review revealed combining CT improves LVR events patients. However, caution needed interpreting results due limited evidence. Future high-quality are support these conclusions. Systematic Review Registration https://www.crd.york.ac.uk/prospero/ , PROSPERO [CRD42022347248].

Language: Английский

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