European Journal of Heart Failure, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Language: Английский
European Journal of Heart Failure, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Aims Accurate selection of patients with severe heart failure (HF) who might benefit from advanced therapies is crucial. The present study investigates the performance available risk scores aimed at predicting mortality in HF. Methods and results 1‐year was estimated HF enrolled HELP‐HF cohort according to MAGGIC, 3‐CHF, ADHF/NT‐proBNP, GWTG‐HF scores, number criteria 2018 HFA‐ESC definition HF, I NEED HELP markers, domains fulfilled 2019 frailty, frailty index, INTERMACS profile. In addition, we tested different machine learning (ML)‐based models predict mortality. At follow‐up, 265 (23.1%) died. prognostic accuracy, subgroup completeness all data regarding variables included (497/1149 patients), resulted moderate for GWTG‐HF, ADHF/NT‐proBNP (area under curve [AUC] ≥0.70) only poor other tools. All lost accuracy estimating rate highest risk. Support vector machine‐based model had best AUC among ML‐based models, slightly outperforming most scores. Conclusion Most used performed poorly real‐world provided inaccurate estimate did not significantly outperform currently their use must be validated large patients.
Language: Английский
Citations
1
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: Jan. 13, 2025
The aim of the study was to assess association between geriatric nutritional risk index (GNRI) and incidence CKD progression, all-cause mortality, cardiovascular events in elderly patients with chronic kidney disease (CKD) before dialysis initiation. We performed a post hoc analysis CKD-ROUTE database, which included 538 pre-dialysis aged ≥65 years this prospective cohort study. Associations GNRI clinical outcomes were estimated using Cox proportional hazards model analysis. Multivariable linear mixed regression models random intercepts used glomerular filtration rate (eGFR) decline per year. During median follow-up period 2.92 years, there 123 (22.86%) progression events, 44 (8.18%) deaths, 76 (14.13%) events. After adjusting for multiple confounding factors, hazard ratios (HRs) <92 1.99 (95% CI, 1.34-2.97; p < 0.001), when compared ≥92. Patients lower also had significantly greater eGFR over time than well-nourished (mean annual difference, -1.69; 95% -2.62 -0.77; 0.001). In secondary outcomes, consistent mortality. Moreover, associations generally across several subgroup sensitivity analyses. is associated higher risks renal prognosis mortality CKD.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 4, 2025
It is unclear whether diabetes mellitus (DM) affects the role of malnutrition in heart failure (HF). We evaluated effect geriatric nutritional risk index (GNRI) on HF prognosis and DM's this relationship. This single-centre retrospective cohort study included 540 patients with data grouped by DM status GNRI score. The primary endpoint was all-cause mortality. Eighty-four (15.6%) were classified as malnourished (GNRI ≤ 98). Over a median follow-up 4.0 years, 102 died. DM/low (L-GNRI) group had highest death (HRadj: 3.253, 95% CI 1.643–6.474, P < 0.001) cardiac 3.411, 1.606–7.243, compared to non-DM/high group. adverse impact L-GNRI more pronounced than non-DM (Pinteraction 0.05). In total population subgroup, independently associated an increased after adjustment (all DM, classification significantly enhanced predictive value model A negative correlation between HbA1c observed only DM. Patients poorest prognosis. Poor glycemic control related risk.
Language: Английский
Citations
0
European Journal of Heart Failure, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 11, 2025
Language: Английский
Citations
0
European Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Abstract Background Atrial fibrillation (AF) and low body weight (BW, <60 kg) are common in patients with heart failure (HF). However, the safety effectiveness of direct oral anticoagulants (DOACs) this group remain unclear. This study compares efficacy apixaban versus vitamin K antagonists (VKAs) nonvalvular AF, BW HF. Methods We analysed 155,152 HF weighing ≤100 kg treated (apixaban 86,493; VKA 68,659), from TriNetX Global Research Network. Outcomes included ischaemic stroke/systemic embolism (SEE), clinically relevant bleedings, intracranial haemorrhage (ICH), all‐cause death net clinical benefit (composite stroke/SEE, bleedings death) across three categories: 60–100 (reference), 50–60 (low BW) ≤50 (very BW). Propensity score matching was used to balance treatment groups. Results Patients had a higher risk adverse events compared those reference BW, regardless treatment. Apixaban consistently reduced stroke/SEE bleeding (including ICH) all ranges (all p ‐interaction >.10), improved (reference BW: HR .82 [95% CI: .80–.84]; .79 .74–.85]; very .86 .78–.95], = .366). significant BW‐treatment interaction observed for mortality, indicating relative vs. as decreases. Conclusion In large real‐world analysis, associated superior profile BW. These results remained consistent, albeit slightly attenuated, findings provide preliminary evidence supporting use high‐risk population.
Language: Английский
Citations
0
European Journal of Heart Failure, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Language: Английский
Citations
0
Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 589 - 589
Published: Feb. 28, 2025
Background/Objectives: Chronic heart failure (CHF) remains a significant global health burden, with high morbidity, prolonged hospitalizations, and increased mortality. Traditional biomarkers such as NT-proBNP provide prognostic value; however, novel biomarker ratios may enhance risk stratification. This study evaluated the predictive utility of NT-proBNP-to-albumin ratio (NTAR), red cell distribution width-to-eGFR (RGR), width-to-fibrinogen (RFR) for hospital length stay (LOS), extended hospitalization (ELOS), in-hospital mortality, 6-month all-cause Methods: A retrospective observational pilot was conducted on 382 CHF admissions (2022-2024) comprehensive laboratory assessment. Biomarker performance assessed through uni- multivariate logistic regression, receiver operating characteristic curve, Cox proportional hazards stepwise methods analyses refining models. Results: NTAR RGR emerged predictors outcomes. demonstrated moderate correlation LOS (r = 0.45, p < 0.001) an independent predictor ELOS (AUC 0.697, OR 2.438, 0.001), outperforming NT-proBNP. Additionally, significantly predicted mortality 0.768, 4.461, 0.766, 4.185, 0.001). strongest 0.785, HR 2.18, 0.005), highlighting its role in renal dysfunction erythropoietic alterations CHF. The RFR observed value minimal. Conclusions: In our study, offered valuable underscoring interplay cardiac stress, nutritional status, function prognosis. Further multicenter validation is warranted these biomarkers.
Language: Английский
Citations
0
Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4401 - 4401
Published: Dec. 21, 2024
Background/Objectives: Malnutrition has been associated with increased morbidity and mortality in elderly patients diagnosed heart failure (HF). However, nutritional problems are underdiagnosed these patients. This study aimed to analyse malnutrition prevalence HF its impact on survival. Methods: We conducted a retrospective observational including aged ≥85 years followed up by specific unit between 2015 2023. All underwent assessment at the start of follow-up. Demographic characteristics, comorbidities, functional, cognitive frailty status, disease characteristics laboratory data, as well admissions, emergency department visits survival, were collected. The sample was categorised according status into normonutrition impaired differences evaluated. Results: Of total 413 patients, 52.8% female, mean age 88.4 ± 2.9 years. A 25.4% risk 2.2% malnourished. Dementia [OR = 3.99, 95%CI (2.32–6.86); p < 0.001], hip fracture 3.54, (1.75–7.16); 0.001)], worse Barthel index score 5.44, (3.15–9.38); 0.001), Pfeiffer test 5.45; (3.29–9.04); Frail 6.19; (2.45–15.61); 0.001] higher Charlson 1.95; (1.21–3.15); 0.006] status. In addition, poor lived 16.69 months less (p 0.001) than normonutrited Conclusions: At least one four under outpatient follow-up an is greater functional decline. Patients who malnourished or survive those not
Language: Английский
Citations
1
European Journal of Heart Failure, Journal Year: 2024, Volume and Issue: 26(8), P. 1665 - 1668
Published: July 26, 2024
Language: Английский
Citations
0
The journal of nutrition health & aging, Journal Year: 2024, Volume and Issue: 28(12), P. 100382 - 100382
Published: Oct. 16, 2024
Language: Английский
Citations
0