Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses DOI Creative Commons
Zhiwen Jiang,

Andres Merits,

Ying Qin

et al.

PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(11), P. e1012700 - e1012700

Published: Nov. 18, 2024

Alphaviruses are important arthropod-transmitted pathogens of humans and livestock. Getah virus (GETV) is an arthritogenic alphavirus that causes disease in horses piglets; it also poses a potential threat to humans. A live attenuated vaccine candidate named GETV-3ΔS2-CM1, harbouring deletion nonstructural protein 3 substitutions the capsid protein, genetically stable exhibits robust immunogenicity. It was shown confer passive protection piglets born immunized sows. In mice, single dose GETV-3ΔS2-CM1 protected against infection with different strains GETV, Semliki Forest virus, Ross River o'nyong'nyong chikungunya Barmah virus. Chimaeras based on backbone maintained both phenotype high The safety, efficacy, ability induce multiple alphaviruses highlights chimaeras using this as promising candidates. By contributing simultaneously wellbeing animals humans, our universal next generation strategy helps achieve "One Health" goals.

Language: Английский

Immunotherapeutic Potential of the Yellow Fever Virus Vaccine Strain 17D for Intratumoral Therapy in a Murine Model of Pancreatic Cancer DOI Creative Commons
Alina S. Nazarenko, Yulia K. Biryukova, Kirill N. Trachuk

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(1), P. 40 - 40

Published: Jan. 6, 2025

Objective: We evaluate the immunotherapeutic potential of yellow fever virus vaccine strain 17D (YFV 17D) for intratumoral therapy pancreatic cancer in mice. Methods: The cytopathic effect YFV on mouse syngeneic cancers cells were studied both vitro and vivo human vitro. Results: demonstrated a strong against Although did not exhibit lytic Pan02 vitro, single administration caused delay tumor growth an increase median survival by 30%. Multiple injections further improve growth; however, it notably extended survival. Furthermore, preliminary immunization with enhanced its oncotherapeutic effect. Conclusions: Intratumoral delayed murine model cancer. fact that affected much more strongly than appears promising. Hence, we anticipate efficacy YFV-17D-based oncolytic will also be higher carcinomas compared to tumor.

Language: Английский

Citations

0
Dual Protection Against Grouper Rana-Iridovirus (Giv-R) and Nervous Necrotic Virus (Nnv) by Novel Giv-R-Δ51_Nnv-Cp Chimeric Vaccine Candidates DOI

Shan Ding,

Yong Li, Qianqian Sun

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dual protection against grouper Rana-Iridovirus (GIV-R) and nervous necrotic virus (NNV) by novel GIV-R-Δ51-NNV-CP chimeric vaccine candidates DOI

Shan Ding,

Yong Li, Qianqian Sun

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: 162, P. 110358 - 110358

Published: April 18, 2025

Language: Английский

Citations

0
From Antibodies to Immunity: Assessing Correlates of Flavivirus Protection and Cross-Reactivity DOI Creative Commons

H. C. Flores,

E. Burgos,

Sigrid Camacho Ortega

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(5), P. 449 - 449

Published: April 24, 2025

Flaviviruses are arthropod-borne RNA viruses that can cause a wide range of human diseases, from mild symptoms to severe illness with multiorgan failure and death. Effective prevention these diseases relies on identifying reliable vaccine targets, typically measured by correlates protection (CoPs), which help indicate host immunity after vaccination. Current vaccines primarily focus neutralizing antibodies (nAbs) against the viral envelope E protein, though emerging evidence suggests other potential targets may also be effective in disease prevention. Additionally, there is growing cross-protection between different flaviviruses when one virus achieved, although this limited antibody-dependent enhancement. This review examines current understanding flavivirus immunity, CoPs, for context existing strategies.

Language: Английский

Citations

0
Natural selection shapes codon usage and host adaptation of NS1 in mosquito-borne pathogenic flaviviruses DOI
Ruichen Wang, Ziyi Li, Qikai Yin

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 292, P. 139187 - 139187

Published: Dec. 28, 2024

Language: Английский

Citations

1
Des vaccins contre la dengue imparfaits mais indispensables DOI

Pr Jean-Daniel Lelièvre

Revue Francophone des Laboratoires, Journal Year: 2024, Volume and Issue: 2024(564), P. 24 - 29

Published: July 1, 2024

Citations

0
Immunogenicity and Protective Efficacy of Aerosolized Live-Attenuated Yellow Fever 17D Vaccine in Mice DOI Creative Commons

Feng Zhu,

Mengxu Sun,

Suo-Qun Zhao

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(8), P. 856 - 856

Published: July 30, 2024

Yellow fever (YF), caused by the yellow virus (YFV), continually spreads and causes epidemics worldwide, posing a great threat to human health. The live-attenuated YF 17D vaccine (YF-17D) has been licensed for preventing YFV infection administrated via intramuscular (i.m.) route. In this study, we sought determine immunogenicity protective efficacy of aerosolized YF-17D intratracheal (i.t.) route in mice. stocks liquids were successfully into particles 6 μm. Further vitro phenotype results showed aerosolization process did not abolish infectivity YF-17D. Meanwhile, single i.t. immunization with induced robust humoral cellular immune responses A129 mice, which is comparable that received i.p. immunization. Notably, also triggered specific secretory IgA (SIgA) production bronchoalveolar lavage. Additionally, all immunized animals survived lethal dose challenge conclusion, our support further development future.

Language: Английский

Citations

0
Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses DOI Creative Commons
Zhiwen Jiang,

Andres Merits,

Ying Qin

et al.

PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(11), P. e1012700 - e1012700

Published: Nov. 18, 2024

Alphaviruses are important arthropod-transmitted pathogens of humans and livestock. Getah virus (GETV) is an arthritogenic alphavirus that causes disease in horses piglets; it also poses a potential threat to humans. A live attenuated vaccine candidate named GETV-3ΔS2-CM1, harbouring deletion nonstructural protein 3 substitutions the capsid protein, genetically stable exhibits robust immunogenicity. It was shown confer passive protection piglets born immunized sows. In mice, single dose GETV-3ΔS2-CM1 protected against infection with different strains GETV, Semliki Forest virus, Ross River o'nyong'nyong chikungunya Barmah virus. Chimaeras based on backbone maintained both phenotype high The safety, efficacy, ability induce multiple alphaviruses highlights chimaeras using this as promising candidates. By contributing simultaneously wellbeing animals humans, our universal next generation strategy helps achieve "One Health" goals.

Language: Английский

Citations

0