Synthesis, structural, equilibrium, anticancer, DNA binding, and computational investigation of binary and ternary palladium(II) complexes based on N-(2-hydroxyethyl)ethylenediamine

Journal of Coordination Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Jan. 31, 2025

Language: Английский

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Influence of the charge of 1,3,5-triaza-7-phosphaadamantane-based ligands on the anticancer activity of organopalladium complexes

RSC Advances, Journal Year: 2025, Volume and Issue: 15(18), P. 14058 - 14071

Published: Jan. 1, 2025

In this study, we report the synthesis and characterization of novel organopalladium complexes featuring 1,3,5-triaza-7-phosphaadamantane (PTA)-based ligands, including several cationic derivatives prepared as hexafluorophosphate salts to prevent halide exchange reactions. The incorporate diverse fragments-Pd(ii)-vinyl, Pd(ii)-butadienyl, Pd(ii)-allyl, Pd(ii)-imidoyl, Pd(ii)-aryl, Pd(0)-alkene-many which have recently shown promising antitumor activity. Most reactions proceeded rapidly at room temperature under aerobic conditions using non-anhydrous solvents. Biological evaluation against ovarian cancer (A2780), cisplatin-resistant (A2780cis), triple-negative breast (MDA-MB-231), glioblastoma (U87), non-cancerous fibroblasts (MRC-5) revealed remarkable cytotoxicity complexes, particularly those with Pd(0)-alkene fragments. These compounds demonstrated activity comparable or exceeding cisplatin, some showing up two orders magnitude greater efficacy. Importantly, were highly selective for cells, exhibiting minimal toxicity toward MRC-5 fibroblasts, unlike cisplatin. Complex 14b, that contains a fragment MePTA+ was only one exhibited excellent across all cell lines, glioblastoma. findings underscore potential PTA-based anticancer agents, warranting further in vitro vivo studies, well mechanistic investigations.

Language: Английский

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THE COMPLEX FORMATION OF PALLADIUM(II) WITH 1-HYDROXY-2-(3-PYRIDYL) ETHYLIDENE­DIPHOSPHONIC (RISEDRONIC) ACID

Ukrainian Chemistry Journal, Journal Year: 2025, Volume and Issue: 91(4), P. 51 - 60

Published: May 7, 2025

The complex formation of K2[PdCl4] with 1-hydroxy-2-(3-pyridyl)ethylidene-diphos­phonic (risedronic, Ris, H4L) acid in aqueous solutions physiological concentration chloride ions (0.15 mol L-1KCl) was studied using pH-potentiometry, UV-Vis and NMR 31Р spectroscopy. It found that the system K2[PdCl4]:Ris=1:1, equimolar complexes are formed, for which constants were calculated as follows: [PdH3LCl3]2- (lgβ=39.26 (4)), [PdH2LCl3]3- (lgβ=35.66 [PdHLCl3]4- (lgβ=30.25 (6)), [PdLCl3]5- (lgβ=22.35 (6)). monodentate mode coordination risedronic to central metal ion via nitrogen atom pyridine ring determined. All have chromophore composition [Pd;Namine;3Cl]. sequential [PdH2LCl3]3-, [PdHLCl3]4-, occurs upon deprotonation phosphonic groups ligand, not directly coordinated Pd(II) ion. Based on constructed diagram equilibrium distribution complexes, it established pH range, predominates. possibility solution from one four molecules acid, depending K2[PdCl4]:Ris ratio values, is shown. In systems = 1:2, 1:3, 1:4 at pH>5 comp­lexes formed two, three, or a ring. These chromophores [Pd;2Namine;2Cl], [Pd;3Namine;Cl], [Pd;4Namine], respectively. presence only single signal δ³¹P~17.3–17.8 ppm ³¹P spectra K₂[PdCl₄]:Ris 1:1, ratios pH>5, along absence signals corresponding phosphonate (typically observed δ³¹P~45–30 ppm), indicates ligand do participate sphere Pd(II).

Language: Английский

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Palladium(II)-Indenyl Complexes Bearing N-Heterocyclic Carbene (NHC) Ligands as Potent and Selective Metallodrugs toward High-Grade Serous Ovarian Cancer Models

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(16), P. 14414 - 14431

Published: Aug. 9, 2024

In this study, we synthesized novel Pd(II)-indenyl complexes using various

Language: Английский

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