Synthetic Communications,
Journal Year:
2023,
Volume and Issue:
53(11), P. 755 - 770
Published: April 19, 2023
Among
the
large
number
of
reports
published
on
strategies
applicable
to
synthesis
pyrazolines
and
its
analogs,
The
1,3-dipolar
cycloaddition
offers
a
remarkably
wide
range
utility.
Many
reactions
used
for
provide
better
selectivity,
eco-friendly,
less
expensive
chemical
processes.
In
presented
study,
we
have
reviewed
various
recently
adopted
pyrazoline
which
followed
mechanism
classified
them
based
starting
materials.
Organic & Biomolecular Chemistry,
Journal Year:
2022,
Volume and Issue:
20(29), P. 5651 - 5693
Published: Jan. 1, 2022
Recent
advances
in
the
chemistry
of
base-,
metal-,
nano-metal
and
organo-catalyst
mediated
achiral
chiral
versions
structurally
diverse
pharmaceutically
relevant
spirooxindoles
are
gently
reviewed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(2), P. 668 - 668
Published: Jan. 9, 2023
Azomethine
ylides
are
nitrogen-based
three-atom
components
commonly
used
in
[3+2]-cycloaddition
reactions
with
various
unsaturated
2π-electron
components.
These
highly
regio-
and
stereoselective
have
attracted
the
attention
of
organic
chemists
respect
to
construction
diverse
heterocycles
potentially
bearing
four
new
contiguous
stereogenic
centers.
This
review
article
complies
most
important
azomethine
olefinic,
(acyclic,
alicyclic,
heterocyclic,
exocyclic
ones)
reported
over
past
two
decades.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(21)
Published: March 16, 2023
Oxindoles
and
iso-oxindoles
are
natural
product-derived
scaffolds
that
provide
inspiration
for
the
design
synthesis
of
novel
biologically
relevant
compound
classes.
Notably,
spirocyclic
connection
oxindoles
with
has
not
been
explored
by
nature
but
promises
to
structurally
related
compounds
endowed
bioactivity.
Therefore,
methods
their
efficient
conclusive
discovery
cellular
targets
highly
desirable.
We
describe
a
selective
RhIII
-catalyzed
scaffold-divergent
spirooxindole-isooxindoles
spirooxindole-oxindoles
from
differently
protected
diazooxindoles
N-pivaloyloxy
aryl
amides
which
includes
functional
group-controlled
Lossen
rearrangement
as
key
step.
Unbiased
morphological
profiling
corresponding
collection
in
Cell
Painting
assay
efficiently
identified
mitotic
kinesin
Eg5
target
spirooxindoles,
defining
unique
inhibitor
chemotype.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(12), P. 2047 - 2052
Published: May 12, 2022
Abstract
The
additive‐free
1,3‐dipolar
cycloaddition
reaction
of
isatin‐derived
azomethine
ylides
with
α‐cyano‐α,β‐unsaturated
compounds
was
developed,
which
enabled
diversity‐oriented
synthesis
a
series
novel
and
structurally
complex
3,3′‐pyrrolidinyl‐spirooxindoles
derivatives
containing
four
contiguous
two
quaternary
stereogenic
centers
in
high
yields
(up
to
92%)
excellent
diastereoselectivities
>25:1
dr).
displays
switchable
regioselectivity
depending
on
the
steric
effect
substrates.
magnified
image
Molecules,
Journal Year:
2023,
Volume and Issue:
28(7), P. 3059 - 3059
Published: March 29, 2023
Heteroarene
1,
n-zwitterions
are
powerful
and
versatile
building
blocks
in
the
construction
of
heterocycles
have
received
increasing
attention
recent
years.
In
particular,
pyridinium
quinolinium
1,4-zwitterions
been
widely
studied
used
a
variety
cyclization
reactions
due
to
their
air
stability,
ease
use,
high
efficiency.
Sulfur-
nitrogen-based
1,4-zwitterions,
types
emerging
heteroatom-containing
synthons,
attracted
much
from
chemists.
These
which
contain
multiple
reaction
sites,
successfully
synthesis
three-
eight-membered
cyclic
compounds
over
last
decade.
this
review,
we
present
exciting
progress
made
field
sulfur-
1,4-zwitterions.
Moreover,
mechanistic
insights,
transition
states,
some
synthetic
applications,
challenges
opportunities
also
discussed.
We
hope
provide
an
overview
for
chemists
who
interested
heterocycle
with
