The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(18), P. 13235 - 13242
Published: Sept. 10, 2024
This study presents the synthesis of novel naphthofurano-iminosugars (
Language: Английский
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(11), P. 5016 - 5022
Published: Oct. 8, 2024
Visible-light-mediated photocatalysis has been widely utilized to produce various organic products due its clean, efficient, and green characteristics. However, examples involving photocatalytic reactions synthesize covalent frameworks (COFs) have rarely reported thus far. Herein, we report for the first time synthesis of a series quinoline-linked COFs with high crystallinity permanent porosity via three-component one-pot Povarov reaction between different aldehydes, amines, phenyl vinyl sulfone. Furthermore, obtained are stable can be employed as efficient photocatalysts promote oxidative hydroxylation arylboronic acids phenols in excellent yields. This polymerization strategy opens new avenue construction facile way.
Language: Английский
Citations
3
Chirality, Journal Year: 2025, Volume and Issue: 37(2)
Published: Jan. 23, 2025
Chirality plays a crucial role in the pharmacological activity of triazoles, key scaffold antifungal agents and various therapeutic applications. This study focuses on optimizing enantiomeric resolution chiral triazoles using supercritical fluid chromatography (SFC) 10 different columns, either immobilized or coated, chlorinated nonchlorinated, cellulose amylose-based stationary phases (CSPs). Four novel two marketed ones (tebuconazole hexaconazole) were separated to determine optimal conditions. The best was achieved CSPs across tested compounds. Optical rotation X-ray crystallography employed absolute configurations purified enantiomers.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Axially chiral diaryl ethers represent a distinct class of atropisomers, characterized by unique dual C─O axes system, which have been found in variety natural products, pharmaceuticals, and ligands. However, the catalytic enantioselective synthesis these atropoisomers poses significant challenges, due to difficulty controlling both axes, their more flexible conformations. Herein, an efficient protocol for axially is presented using organocatalyzed asymmetric Povarov reaction-enabled desymmetrization, followed aromatizations. This method yields wide range novel quinoline-based ether good high enantioselectivities. Notably, various aromatization protocols are developed, resulting diverse set polysubstituted quinoline-containing atropisomers. Thermal racemization studies suggested excellent configurational stabilities atropisomers (with barriers up 38.1 kcal mol
Language: Английский
Citations
3
Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(23), P. 6530 - 6534
Published: Jan. 1, 2022
A simple and efficient one-pot protocol has been developed by an aza-Diels–Alder mechanism for the stereoselective synthesis of novel fused multicyclic iminosugars with structural diversity.
Language: Английский
Citations
11
Organic Letters, Journal Year: 2022, Volume and Issue: 24(35), P. 6397 - 6401
Published: Aug. 26, 2022
An asymmetric organocatalyzed three-component Povarov reaction to construct azaspirocycles has been developed. A chiral phosphoric acid OCF-CPA bearing o-CF3-aryl on the H8–BINOL-framework is highly efficient in reaction. The was carried out under mind conditions for synthesis of a range high yields and excellent enantioselectivities, thus expending substrate scope traditional
Language: Английский
Citations
10
Chinese Journal of Chemistry, Journal Year: 2023, Volume and Issue: 42(2), P. 142 - 150
Published: Sept. 15, 2023
Comprehensive Summary Different novel fused multicyclic iminosugars were synthesized from D‐ribose tosylate, aniline and vinyl ethyl ether by one‐pot three‐component stereoselective [4+2] reaction at different temperatures. The iminium‐ion is the key intermediate for reaction. As a result, several complex 3a obtained aza‐Diels‐Alder mechanism 60 °C, while series of aza‐ C ‐glycosides 5a prepared Mannich room temperature accompanied another tetrahydroquinoline‐fused 4a (tricyclic derivatives) through cycloaddition. This strategy will help to construct structurally diverse bioactive iminosugar analogues.
Language: Английский
Citations
6
Chemical Synthesis, Journal Year: 2023, Volume and Issue: 3(2), P. 9 - 9
Published: Jan. 1, 2023
Quinidine-catalyzed regio- and enantioselective formal [4 + 2]-cycloadditions of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates with N-tosyl-2-methylenebut-3-enoates 2-methylene-3-oxoalkanoates have been developed for the first time. The reaction features in situ formation chiral nitrogen-containing dipolar intermediates, a ring-opening/Michael addition/annulation cascade works well over broad substrate scope to furnish tetrahydroquinolines high yields asymmetric induction under mild conditions.
Language: Английский
Citations
5
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(17), P. 12445 - 12450
Published: Aug. 18, 2023
An efficient and convenient strategy has been successfully developed for the preparation of novel furantetrahydroquinoline derivatives using d/l-ribose with a 2,3-O-isopropylidene group through aza-Diels-Alder mechanism. This method high atom step economy, stereoselectivity, gram-scale synthesis (yield 67%).
Language: Английский
Citations
5
Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(24), P. 6219 - 6224
Published: Jan. 1, 2023
This protocol provides concise access to enantioenriched pyrroloquinolines, and presents an alternative methodology for functionalizing the carbocyclic ring of indoles.
Language: Английский
Citations
4
Molecular Catalysis, Journal Year: 2024, Volume and Issue: 568, P. 114487 - 114487
Published: Aug. 29, 2024
Language: Английский
Citations
1