Synergistic Cobaloxime Catalysis for Photo-Dehydrogenative Transformations DOI
Aindrila Mandal, Melissa Lim,

Lili Zhang

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 9976 - 10004

Published: May 29, 2025

Language: Английский

Photocatalytic Late-Stage C–H Functionalization DOI
Peter Bellotti, Huan‐Ming Huang,

Teresa Faber

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(8), P. 4237 - 4352

Published: Jan. 24, 2023

The emergence of modern photocatalysis, characterized by mildness and selectivity, has significantly spurred innovative late-stage C–H functionalization approaches that make use low energy photons as a controllable source. Compared to traditional strategies, photocatalysis paves the way toward complementary and/or previously unattainable regio- chemoselectivities. Merging compelling benefits with workflow offers potentially unmatched arsenal tackle drug development campaigns beyond. This Review highlights photocatalytic strategies small-molecule drugs, agrochemicals, natural products, classified according targeted bond newly formed one. Emphasis is devoted identifying, describing, comparing main mechanistic scenarios. draws critical comparison between established ionic chemistry photocatalyzed radical-based manifolds. aims establish current state-of-the-art illustrate key unsolved challenges be addressed in future. authors aim introduce general readership functionalization, specialist practitioners evaluation methodologies, potential for improvement, future uncharted directions.

Language: Английский

Citations

336

Ligand‐to‐Metal Charge Transfer (LMCT) Photochemistry at 3d‐Metal Complexes: An Emerging Tool for Sustainable Organic Synthesis DOI Creative Commons
Fabio Juliá

ChemCatChem, Journal Year: 2022, Volume and Issue: 14(19)

Published: Aug. 11, 2022

Abstract Despite the rich photochemistry of 3d‐metal complexes, utilization excited‐state reactivity these compounds in organic synthesis has been historically overlooked. The advent photoredox catalysis changed perception synthetic chemists towards photochemistry, and nowadays potential photoinduced, outer‐sphere single‐electron transfer events is widely recognized. More recently, an emerging new mode photoactivation taken spotlight, based on inner‐sphere triggered by population ligand‐to‐metal charge‐transfer (LMCT) excited states. Contrarily to photoredox, LMCT‐activation does not rely matching redox potentials, offers unique profiles particularly well suited Earth‐abundant metal complexes. Those appealing features are propelling development methods using this blueprint generate highly reactive open‐shell species under mild conditions. aim contribution provide a didactical tool for comprehension concept facilitate methodologies achieve sustainable chemical transformations.

Language: Английский

Citations

232

Degradation of Polyacrylates by One-Pot Sequential Dehydrodecarboxylation and Ozonolysis DOI

Angie B. Korpusik,

Alafate Adili,

Kamal Bhatt

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(19), P. 10480 - 10485

Published: May 8, 2023

We establish a synthetically convenient method to degrade polyacrylate homopolymers. Carboxylic acids are installed along the polymer backbone by partial hydrolysis of ester side chains, and then, in one-pot sequential procedure, carboxylic converted into alkenes oxidatively cleaved. This process enables robustness properties polyacrylates be maintained during their usable lifetime. The ability tune degree degradation was demonstrated varying acid content polymers. is compatible with wide range polymers prepared from vinyl monomers through copolymerization acrylic different including acrylates, acrylamides, styrenics.

Language: Английский

Citations

52

A Dual Cobalt and Photoredox Catalysis for Hydrohalogenation of Alkenes DOI

Shotaro Shibutani,

Kazunori Nagao, Hirohisa Ohmiya

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(7), P. 4375 - 4379

Published: Feb. 1, 2024

We demonstrate hydrohalogenation of aliphatic alkenes with collidine·HX salts through dual photoredox/cobalt catalysis. The catalysis enables conversion a proton and halide anion from salt to nucleophilic hydrogen radical equivalent an electrophilic halogen delivery them alkene moiety. This protocol allows for introduction fluorine, chlorine, bromine, or iodine atom alkene, producing highly functionalized alkyl halides.

Language: Английский

Citations

26

Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop DOI Creative Commons
Sebastian B. Beil, Sylvestre Bonnet, Carla Casadevall

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(8), P. 2746 - 2766

Published: Aug. 8, 2024

Photocatalysis is a versatile and rapidly developing field with applications spanning artificial photosynthesis, photo-biocatalysis, photoredox catalysis in solution or supramolecular structures, utilization of abundant metals organocatalysts, sustainable synthesis, plastic degradation. In this Perspective, we summarize conclusions from an interdisciplinary workshop young principal investigators held at the Lorentz Center Leiden March 2023. We explore how diverse fields within photocatalysis can benefit one another. delve into intricate interplay between these subdisciplines, by highlighting unique challenges opportunities presented each multidisciplinary approach drive innovation lead to solutions for future. Advanced collaboration knowledge exchange across domains further enhance potential photocatalysis. Artificial photosynthesis has become promising technology solar fuel generation, instance, via water splitting CO

Language: Английский

Citations

22

Photo‐ and Cobalt‐Catalyzed Synthesis of Heterocycles via Cycloisomerization of Unactivated Olefins DOI Creative Commons
Henry Lindner, Willi M. Amberg, Tristano C. Martini

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(19)

Published: Feb. 28, 2024

Abstract We report a general, intramolecular cycloisomerization of unactivated olefins with pendant nucleophiles. The reaction proceeds under mild conditions and tolerates ethers, esters, protected amines, acetals, pyrazoles, carbamates, arenes. It is amenable to N ‐, O as well C ‐nucleophiles, yielding number different heterocycles including, but not limited to, pyrrolidines, piperidines, oxazolidinones, lactones. Use both benzothiazinoquinoxaline organophotocatalyst Co‐salen catalyst obviates the need for stoichiometric oxidant or reductant. showcase utility protocol in late‐stage drug diversification synthesis several small natural products.

Language: Английский

Citations

19

Regio- and Stereoselective Reductive Coupling of Alkynes and Crotononitrile DOI
Kun Cui, Yanlin Li, Gongqiang Li

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(50), P. 23001 - 23009

Published: Dec. 8, 2022

A new regio- and stereoselective reductive coupling of alkynes crotononitrile has been developed via visible light organophotoredox cobalt dual catalysis. variety enantioenriched homoallylic nitriles bearing a stereodefined trisubstituted alkene have easily synthesized with good to excellent (up >20:1 rr), stereo- (>20:1 E/Z), enantioselectivity 98% ee) control under mild conditions. The corresponding nitrile products were smoothly converted into various chiral building blocks. Remarkably, simple organic base together water utilized as hydrogen sources in this photoinduced reaction.

Language: Английский

Citations

41

Recent advances in C(sp3)–N bond formation via metallaphoto-redox catalysis DOI
Juan Zhang,

Xiao-Die Huan,

Xin Wang

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(50), P. 6340 - 6361

Published: Jan. 1, 2024

In this review, the state-of-the-art advances in radical-involved C(sp 3 )–N bond formation via metallaphotoredox catalysis have been highlighted, which are organized according to different catalytic modes, reaction types, and substrate classes.

Language: Английский

Citations

14

Biomimetic Photoexcited Cobaloxime Catalysis in Organic Synthesis DOI Creative Commons
Phong Dam, Kaiming Zuo, Luis Miguel Azofra

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(33)

Published: May 22, 2024

Abstract Drawing inspiration from nature has long been a cornerstone of chemical innovation, with natural systems offering wealth untapped potential for discovery. In this minireview, we delve into the burgeoning field cobaloxime catalysis in organic synthesis, which mimics catalytic activity organometallic alkylcobalamine enzymes. Our focus lies on elucidating latest advancements area, as well delineating primary mechanistic pathways at play. By describing, and comparing these mechanisms, provide comprehensive overview current state‐of‐the‐art, while also shedding light key unresolved challenges that await further exploration.

Language: Английский

Citations

13

Photocatalytic Deuterium Atom Transfer Deuteration of Electron‐Deficient Alkenes with High Functional Group Tolerance DOI
Akihiko Suzuki,

Yuji Kamei,

Masaaki Yamashita

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(3)

Published: Nov. 17, 2022

Abstract Due to its mild reaction conditions and unique chemoselectivity, hydrogen atom transfer (HAT) hydrogenation represents an indispensable method for the synthesis of complex molecules. Its analog using deuterium, deuterium (DAT) deuteration, is expected enable access deuterium‐labeled compounds. However, DAT deuteration has been scarcely studied synthetic purposes, a that possesses favorable characteristics HAT hydrogenations remained elusive. Herein, we report protocol photocatalytic electron‐deficient alkenes. In contrast previous this tolerates variety synthetically useful functional groups including haloarenes. The late‐stage also allows deuterated amino acids as well donepezil‐ d 2 . Thus, work demonstrates potential chemistry become alternative choice preparing deuterium‐containing

Language: Английский

Citations

39