Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(26), P. 5592 - 5596
Published: June 24, 2024
Imidazoline
is
an
important
scaffold
in
organic
synthesis
and
a
pharmacophore
medicinal
chemistry.
We
apply
basic
imines
as
nucleophiles
for
the
catalytic
asymmetric
chloroiminocyclization
to
furnish
tetrasubstituted
stereocenter-containing
imidazolines
excellent
yields
enantioselectivities.
The
reaction
can
be
conducted
polar
solvent
acetonitrile
under
concentrated
conditions.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2023,
Volume and Issue:
6, P. 100352 - 100352
Published: Aug. 18, 2023
In
this
study,
the
synthesis
of
a
new
chitosan-based
Schiff
base
with
surface
modification
using
chloroethanoic
acid
was
reported.
The
physicochemical
attributes
modified
chitosan
were
studied.
characterized
X-ray
diffraction
(XRD)
technique;
Fourier
transform
infrared
(FTIR)
and
UV-visible
spectroscopies;
thermogravimetric
analysis;
differential
scanning
calorimetry
(DSC).
Bruner-Emmett-Teller
(BET)
analysis
performed
to
determine
area
synthesized
compound
electron
microscope
(SEM)
characterize
its
morphology.
adsorption
efficacy
Bismarck
Brown
R
evaluated
through
multilayer
formation,
whereas
Eosin
Y
adsorbed
onto
homogenous
formation
monolayer.
Additionally,
base's
for
BBR
EY
dye
calculated
be
327
mg/g
386
mg/g,
respectively.
effectively
inhibited
both
gram
positive
negative
bacteria,
thus,
exhibiting
antibacterial
properties.
results
showed
that
could
used
remove
dyes
from
wastewater.
Chemistry - An Asian Journal,
Journal Year:
2022,
Volume and Issue:
17(24)
Published: Oct. 18, 2022
Gold
catalysis
is
an
extremely
enthusiastic
field
of
investigation
in
the
area.
The
development
alternative,
highly
inventive,
precompetitive
techniques
based
on
gold
has
paved
way
for
executing
a
broad
spectrum
chemical
transformations
from
uncomplicated
starting
materials.
total
synthesis
natural
products
complex
and
more
complicated
task.
An
amalgamation
product
through
gold-catalysis
been
thought-provoking
job.
protocol
solved
several
problems
related
to
numerous
products.
Thus,
this
review
outlined
some
most
notable
benchmarks
last
seven
years
(2015-2021)
their
application
strategy
acquired
by
authors
accomplish
will
be
elaborately
discussed
emphasizing
role
gold-catalyzed
reactions.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(12), P. 7830 - 7838
Published: Jan. 25, 2023
An
efficient
enantioselective
synthesis
of
γ-chiral
α-spiro-γ-lactones,
which
are
important
building
blocks
for
pharmaceuticals,
was
achieved
via
BINOL-derived
chiral
bifunctional
sulfide-catalyzed
bromolactonizations
α-allyl
carboxylic
acids
containing
either
hetero-
or
carbocyclic
structures.
Transformations
the
resultant
α-spiro-type
bromolactonization
product
were
examined
to
obtain
optically
active
γ-functionalized
α-spiro-γ-lactones.
The
utility
this
catalytic
system
also
demonstrated
in
asymmetric
α,α-diaryl-
and
dialkyl-substituted
γ-lactones.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(8)
Published: Feb. 25, 2023
We
describe
regio-
and
enantioselective
bromocyclization
of
difluoroalkenes
catalyzed
by
chiral
bisphosphine
oxides.
Owing
to
the
simultaneous
activation
both
brominating
reagent
amide
substrate,
desired
cyclization
reaction
proceeds
smoothly
even
at
low
temperature
provide
bromodifluoromethyl-containing
oxazolines
with
a
quaternary
center
in
highly
fashion
(up
99%
ee).
This
protocol
features
use
commercially
available
reagents
readily
accessible
catalysts.
The
regioselectivity
enantioselectivity
are
influenced
catalyst
structure,
reagent,
temperature.
Under
optimal
conditions,
5-exo
preferentially
compared
6-endo
cyclization,
depending
on
electronic
properties
alkene
substrates.
A
gram-scale
synthesis
oxazoline
was
achieved
as
little
1
mol
%
catalyst.
