Oxidative Alkenylation of (Hetero)aromatics with Unactivated Alkenes: Control of the Reaction Selectivity DOI
Chenhui Hu, Keyu Xiang, Ying Tao

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(9), P. 1922 - 1949

Published: Feb. 23, 2024

Abstract Alkenylbenzene skeletons represent one of the most widely occurring structural motifs in pharmaceutical drugs, natural products, and advanced materials. The construction alkenylbenzenes is promising through use a straightforward oxidative alkenylation protocol, particularly from unactivated alkenes. This significant because alkenes are inexpensive raw materials that can be obtained bulk quantities petrochemical feedstocks renewable resources. However, controlling reactivity regioselectivity olefination with unbiased olefins remains challenge, necessitating continuous efforts potentially having substantial impact on both organic synthesis industry. review aims to provide an overview latest advances regiocontrol strategies for reactions alkenes, which categorized into three types: 1) ligand‐promoted/accelerated reactions; 2) prefunctionalized olefins‐facilitated 3) directing group‐induced reactions.

Language: Английский

Oxidative Alkenylation of (Hetero)aromatics with Unactivated Alkenes: Control of the Reaction Selectivity DOI
Chenhui Hu, Keyu Xiang, Ying Tao

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(9), P. 1922 - 1949

Published: Feb. 23, 2024

Abstract Alkenylbenzene skeletons represent one of the most widely occurring structural motifs in pharmaceutical drugs, natural products, and advanced materials. The construction alkenylbenzenes is promising through use a straightforward oxidative alkenylation protocol, particularly from unactivated alkenes. This significant because alkenes are inexpensive raw materials that can be obtained bulk quantities petrochemical feedstocks renewable resources. However, controlling reactivity regioselectivity olefination with unbiased olefins remains challenge, necessitating continuous efforts potentially having substantial impact on both organic synthesis industry. review aims to provide an overview latest advances regiocontrol strategies for reactions alkenes, which categorized into three types: 1) ligand‐promoted/accelerated reactions; 2) prefunctionalized olefins‐facilitated 3) directing group‐induced reactions.

Language: Английский

Citations

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