One-Pot Synthesis of Tricyclic Benzoxazines and Benzoxazepine by Heterogeneous Biochemo Multienzyme Cascade Reaction DOI Creative Commons
Eliana Capecchi,

Elisabetta Tomaino,

Bruno Mattia Bizzarri

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Benzoxazine and benzoxazepine derivatives with tricyclic five-, six-, seven-membered lactone lactam rings were synthesized in one-pot conditions by using biochemo multienzyme cascade of lipase M tyrosinase. The reaction involves tyrosinase-mediated ortho-hydroxylation the phenolic moiety, followed 1,6-Michael addition tandem intramolecular ring closure. method achieves high atom economy, minimizes purification steps, provides a sustainable alternative to conventional multistep syntheses. Enzymes showed excellent reusability, further enhancing green approach.

Language: Английский

One-Pot Synthesis of Tricyclic Benzoxazines and Benzoxazepine by Heterogeneous Biochemo Multienzyme Cascade Reaction DOI Creative Commons
Eliana Capecchi,

Elisabetta Tomaino,

Bruno Mattia Bizzarri

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Benzoxazine and benzoxazepine derivatives with tricyclic five-, six-, seven-membered lactone lactam rings were synthesized in one-pot conditions by using biochemo multienzyme cascade of lipase M tyrosinase. The reaction involves tyrosinase-mediated ortho-hydroxylation the phenolic moiety, followed 1,6-Michael addition tandem intramolecular ring closure. method achieves high atom economy, minimizes purification steps, provides a sustainable alternative to conventional multistep syntheses. Enzymes showed excellent reusability, further enhancing green approach.

Language: Английский

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