Catalytic Generation and Intermolecular Addition of Diarylmethyl Anions Utilizing [1,2]‐Phospha‐Brook Rearrangement Under Brønsted Base Catalysis DOI Creative Commons
Azusa Kondoh, Masahiro Terada

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(8), P. 1857 - 1862

Published: Feb. 21, 2024

Abstract An intermolecular addition reaction involving an unconventional combination of a diarylmethyl anion and electrophile, which is mediated by the [1,2]‐phospha‐Brook rearrangement under Brønsted base catalysis, was developed. Diarylmethyl anions having benzofuran moiety were generated through with aid catalytic amount phosphazene P2‐ t Bu. The resulting carbanion intermediates trapped various electrophiles, such as α,β‐unsaturated ketones, aryl aldehydes, α‐ketoesters, N ‐Boc imines, providing corresponding diarylalkane derivatives in good yields.

Language: Английский

Catalytic Generation and Intermolecular Addition of Diarylmethyl Anions Utilizing [1,2]‐Phospha‐Brook Rearrangement Under Brønsted Base Catalysis DOI Creative Commons
Azusa Kondoh, Masahiro Terada

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(8), P. 1857 - 1862

Published: Feb. 21, 2024

Abstract An intermolecular addition reaction involving an unconventional combination of a diarylmethyl anion and electrophile, which is mediated by the [1,2]‐phospha‐Brook rearrangement under Brønsted base catalysis, was developed. Diarylmethyl anions having benzofuran moiety were generated through with aid catalytic amount phosphazene P2‐ t Bu. The resulting carbanion intermediates trapped various electrophiles, such as α,β‐unsaturated ketones, aryl aldehydes, α‐ketoesters, N ‐Boc imines, providing corresponding diarylalkane derivatives in good yields.

Language: Английский

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