Alkoxylation and Phosphorylation of Pyrimidine Disulfides: Green Synthesis of Alkoxypyrimidine Thioethers and Pyrimidine Phosphorothioates

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

This paper addresses a novel, green, and sustainable method to construct new C–S P–S bonds by cleaving the S–S bond in pyrimidine disulfide under various conditions. The first alkoxylation phosphorylation of are effectively accomplished this approach. Compared methods reported, approach provides more benefits, including utilization eco-friendly solvents, straightforward procedure, mild reaction conditions, high atomic efficiency, broad range applicable substrates. As result, we were able synthesize variety phosphorothioate lipids with potential applications. Furthermore, series control experiments as well theoretical calculations performed work produce deeper insights transfer mechanism.

Language: Английский

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2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101425 - 101425

Published: Jan. 1, 2024

Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter action organs. Herein, we demonstrate synthesis, biological evolution newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating drug likeness, score. The In- vitro viability using lipofectamine 2000 as reference, reveals that IC50 values for pyrimidine-II, III against GL261, pyrimidine- VIII,IX 4 T1 Celline shows prominent results.

Language: Английский

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Six-membered ring systems: Diazines and benzo derivatives

Progress in heterocyclic chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 355 - 393

Published: Jan. 1, 2024

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