Iridium(III)-Catalyzed Cyclization of Oximes with Iodonium Ylides: Synthesis of Multisubstituted Heterocyclic N-Oxides
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 29, 2025
Iridium(III)-catalyzed
regioselective
cyclization
of
substituted
oximes
with
iodonium
ylides
has
been
described.
This
methodology
offered
multisubstituted
heterocyclic
N-oxides
under
mild
reaction
conditions
in
a
redox-neutral
manner.
The
was
also
compatible
vinyl
oximes.
Additionally,
substrate
diversification
carried
out
to
illustrate
the
synthetic
application
protocol.
A
possible
mechanism
involving
C-H
bond
activation
proposed
as
well
supported
by
isolation
key
five-membered
iridacycle
intermediate.
Language: Английский
Transition-Metal-Catalyzed Directed C–H Bond Functionalization with Iodonium Ylides: A Review of the Last 5 Years
Juting Liao,
No information about this author
Dulin Kong,
No information about this author
Xiaoyang Gao
No information about this author
et al.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(15), P. 3567 - 3567
Published: July 29, 2024
Transition-metal-catalyzed
directed
C-H
functionalization
with
various
carbene
precursors
has
been
widely
employed
for
constructing
a
wide
range
of
complex
and
diverse
active
molecules
through
metal
migratory
insertion
processes.
Among
precursors,
iodonium
ylides
serve
as
novel
emerging
precursor
features
including
easy
accessibility,
thermal
stability
high
activity,
which
have
attracted
great
attention
from
organic
chemists
achieved
tremendous
success
in
transformation.
In
this
review,
recent
progress
on
the
application
multifunctional
coupling
characteristics
bond
activation
reactions
is
summarized,
potential
discussed.
Language: Английский