Catalytic Synthesis of Atropoisomers via Non‐Canonical Friedel‐Crafts Reactions DOI

Xutong Ye,

Xixiang Yu,

Rui Deng

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(8), P. 1670 - 1706

Published: Feb. 29, 2024

Abstract The Friedel‐Crafts reaction stands as a powerful synthetic tool for C−H functionalization of aromatic feedstocks, which is conventionally realized through electrophilic alkylation and acylation. burgeoning interests in axially chiral compounds across diverse fields have spurred extensive exploration this classic transformation catalytic atroposelective synthesis. Consequently, the past decade has witnessed rapid expansion various non‐canonical reactions, including arylation, alkenylation, halogenation, sulfenylation, amination aryl bonds, thereby delving into new chemical spaces. A range methods been devised these significant arene functionalization. This review provides comprehensive overview cutting‐edge synthesis atropoisomers categorized three parts based on type bond formation aromatics: C( sp 2 )−C( 3 ) formations, formations )−heteroatom formations. richness electrophiles modulation atroposelectivity by organocatalysts, particularly Brønsted acids, are elucidated. We anticipate that repertoire asymmetric will continue to flourish be demonstrated not only scientific researches but also industrial organic

Language: Английский

Catalytic Synthesis of Atropoisomers via Non‐Canonical Friedel‐Crafts Reactions DOI

Xutong Ye,

Xixiang Yu,

Rui Deng

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(8), P. 1670 - 1706

Published: Feb. 29, 2024

Abstract The Friedel‐Crafts reaction stands as a powerful synthetic tool for C−H functionalization of aromatic feedstocks, which is conventionally realized through electrophilic alkylation and acylation. burgeoning interests in axially chiral compounds across diverse fields have spurred extensive exploration this classic transformation catalytic atroposelective synthesis. Consequently, the past decade has witnessed rapid expansion various non‐canonical reactions, including arylation, alkenylation, halogenation, sulfenylation, amination aryl bonds, thereby delving into new chemical spaces. A range methods been devised these significant arene functionalization. This review provides comprehensive overview cutting‐edge synthesis atropoisomers categorized three parts based on type bond formation aromatics: C( sp 2 )−C( 3 ) formations, formations )−heteroatom formations. richness electrophiles modulation atroposelectivity by organocatalysts, particularly Brønsted acids, are elucidated. We anticipate that repertoire asymmetric will continue to flourish be demonstrated not only scientific researches but also industrial organic

Language: Английский

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