Bioorthogonal Chemistry at Radboud University: Past, Present and Future
Synlett,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 14, 2024
Abstract
Over
the
past
two
decades,
bioorthogonal
chemistry
has
profoundly
impacted
various
chemistry-related
fields,
including
chemical
biology
and
drug
delivery.
This
transformative
progress
stems
from
collaborative
efforts
involving
chemists
biologists,
underscoring
importance
of
interdisciplinary
research.
In
this
Account,
we
present
developments
in
within
our
Institute
for
Molecules
Materials
at
Radboud
University.
The
disclosed
here
spans
strained
alkynes
alkenes
to
release
bioconjugation
strategies,
mirroring
extensive
scope
provided
by
chemistry.
By
reflecting
on
originating
University,
Account
emphasizes
that
teamwork
is
essential
driving
significant
1
Introduction
2
Providing
BCN
as
a
Robust
Bioorthogonal
Tool
Chemical
Biology
Beyond
3
Towards
Readily
Available
Click-to-Release
trans-Cyclooctenes
4
Giving
Guidance
5
Next
Generation
Bioconjugation
Strategies:
Dynamic
Click
Chemistry
6
Conclusions
Language: Английский
Functional 1,2,4,5‐Tetrazine Systems for Photocatalysis and Sensing
M. Rajeswara Rao,
No information about this author
Aswani Raj K
No information about this author
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 13, 2024
Abstract
s‐Tetrazines
are
aromatic
heterocyclic
systems
with
distinct
structural
and
optoelectronic
features,
which
have
led
to
the
design
development
of
tetrazine‐derived
in
various
applications.
In
this
review,
we
summarize
all
research
reported
on
subject
applicability
tetrazine
derivatives
for
photocatalytic
chemical
transformation,
hydrogen
production,
coordination‐based
analyte
detection.
Language: Английский
Cutting-edge bioorthogonal chemistry: Innovations, practical applications, and emerging trends
European Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
15(4), P. 355 - 365
Published: Dec. 31, 2024
Bioorthogonal
chemistry
has
emerged
as
a
pivotal
field
in
molecular
science,
offering
transformative
tools
for
applications
drug
discovery,
imaging,
and
biology.
This
review
provides
comprehensive
analysis
of
recent
advancements
bioorthogonal
chemistry,
emphasizing
key
innovations,
practical
applications,
future
research
directions.
We
explore
state-of-the-art
reactions,
including
Staudinger
ligation,
strain-promoted
azide-alkyne
cycloaddition
(SPAAC),
tetrazine
detailing
their
mechanisms,
advantages,
limitations.
The
highlights
significant
innovations
such
novel
fluorogenic
probes,
improved
catalysts,
enhanced
reaction
conditions
that
have
expanded
the
utility
efficiency
these
reactions.
Practical
are
examined,
showing
how
advances
revolutionized
fields
like
live-cell
targeted
delivery,
labeling.
Looking
to
future,
we
discuss
emerging
trends
potential
avenues,
integration
with
other
advanced
technologies
development
new
methodologies.
detailed
overview
current
state
outlines
its
potential,
serving
valuable
resource
researchers
practitioners
field.
Language: Английский
Cost‐effective synthesis of unsymmetric tetrazines
Bulletin of the Korean Chemical Society,
Journal Year:
2024,
Volume and Issue:
45(10), P. 867 - 872
Published: Oct. 1, 2024
Abstract
1,2,4,5‐Tetrazines
serve
as
versatile
two‐carbon
synthons,
essential
for
synthesizing
a
variety
of
(hetero)aromatic
compounds.
Their
specific
reactivity
with
certain
dienophiles,
without
interfering
biochemical
processes,
makes
them
ideal
bioorthogonal
ligation.
Despite
their
broad
utility,
current
synthetic
methods
are
costly
and
raise
safety
concerns,
particularly
during
scale‐up.
This
study
introduces
safer
more
cost‐effective
strategies
utilizing
zinc
chloride
or
boron
trifluoride
diethyl
etherate
catalysts.
These
alternatives
significantly
reduce
costs
enhance
safety,
potentially
expanding
the
applicability
tetrazine
synthesis
across
broader
research
domains.
Language: Английский