Advances in Direct Fluoroalkylation of Organic Substrates with Partially Fluorinated Alkyl Motivs

ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(21), P. 15879 - 15907

Published: Oct. 11, 2024

Partially fluorinated alkyl groups other than methyl are increasingly playing crucial roles in the development of drugs with diverse biological activities, thus creating an innovative chemical space within organofluorine chemistry. For studies structure–activity relationships, late-stage modification such or substituents into substrates that bear activity is essential. This perspective will study catalytic protocols for direct introduction partially monofluoroalkylated (−CHFR, –CH2CH2F), difluoroalkylated (−CF2Me, –CH2CF2H), trifluoroalkylated (−CHR(CF3), –CH2CF3, –CH2CH2CF3, –CH(Me)CF3, –C(Me)2CF3), and pentafluoropropylated (−CH2C2F5) onto (hetero)aromatic compounds, double bonds, isonitriles, halides, N, O, S atoms.

Language: Английский

Recent advances in site-selective C H functionalization of naphthalenes: An update 2020–2024

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 154, P. 155370 - 155370

Published: Nov. 17, 2024

Language: Английский