Base Promoted Hydrogenation of N-Heteroarenes with Ammonia Borane and DMSO DOI
Dongxu Jia, Zhenkang Ai,

Xinya Yuan

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Herein, we report a sodium tert-butoxide-promoted reduction of N-heteroarenes using ammonia borane and dimethyl sulfoxide (DMSO) under mild reaction conditions. This method demonstrates broad functional group compatibility across diverse N-heteroarene substrates. Notably, substituting DMSO with deuterated DMSO-d6 enables the synthesis C3-deuterated 1,2,3,4-tetrahydroquinolines remarkable positional selectivity. Mechanistic investigations indicate that protons are derived from both DMSO. strategy establishes novel environmentally benign approach for (deuterated) N-heterocycles, offering practical advantages in terms operational simplicity sustainable

Language: Английский

Preparation of Mesoporous Chitosan Cobalt Supported Nano-Catalyst for the Catalyzed Reduction of Quinoline to N-formyltetrahydroquinoline DOI
Lan Wu, Yongchao Liu,

Ze Wang

et al.

Catalysis Letters, Journal Year: 2025, Volume and Issue: 155(5)

Published: April 9, 2025

Language: Английский

Citations

0
Base Promoted Hydrogenation of N-Heteroarenes with Ammonia Borane and DMSO DOI
Dongxu Jia, Zhenkang Ai,

Xinya Yuan

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Herein, we report a sodium tert-butoxide-promoted reduction of N-heteroarenes using ammonia borane and dimethyl sulfoxide (DMSO) under mild reaction conditions. This method demonstrates broad functional group compatibility across diverse N-heteroarene substrates. Notably, substituting DMSO with deuterated DMSO-d6 enables the synthesis C3-deuterated 1,2,3,4-tetrahydroquinolines remarkable positional selectivity. Mechanistic investigations indicate that protons are derived from both DMSO. strategy establishes novel environmentally benign approach for (deuterated) N-heterocycles, offering practical advantages in terms operational simplicity sustainable

Language: Английский

Citations

0