NHC‐Catalyzed, Microwave‐Assisted and Base‐Dependent Reactions of Substituted Cinnamaldehydes Towards γ‐Lactones or Saturated Esters DOI Creative Commons
Victoria Magrioti, Evanthia Papadaki,

Antonia Kapoti

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract N‐Heterocyclic carbenes (NHCs) generated from imidazolium, imidazopyridinium and imidazoquinolinium hydrochlorides in situ using base microwave irradiation were employed as organocatalysts to yield homoenolates cinnamaldehyde its aryl‐substituted analogs. Depending on the catalytic either γ‐lactones prepared when strong tBuOK was used or corresponding saturated ethyl 3‐aryl propionates synthesized with milder DIPEA base. Novel compared commercially available NHCs IMes IDip for their activity. The optimum reaction conditions established broad scope of both reactions investigated 4 most efficient NHCs.

Language: Английский

NHC‐Catalyzed, Microwave‐Assisted and Base‐Dependent Reactions of Substituted Cinnamaldehydes Towards γ‐Lactones or Saturated Esters DOI Creative Commons
Victoria Magrioti, Evanthia Papadaki,

Antonia Kapoti

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract N‐Heterocyclic carbenes (NHCs) generated from imidazolium, imidazopyridinium and imidazoquinolinium hydrochlorides in situ using base microwave irradiation were employed as organocatalysts to yield homoenolates cinnamaldehyde its aryl‐substituted analogs. Depending on the catalytic either γ‐lactones prepared when strong tBuOK was used or corresponding saturated ethyl 3‐aryl propionates synthesized with milder DIPEA base. Novel compared commercially available NHCs IMes IDip for their activity. The optimum reaction conditions established broad scope of both reactions investigated 4 most efficient NHCs.

Language: Английский

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