Treatment of Osteoporosis and Osteoarthritis in the Oldest Old

Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Commentary to ‘Movement‐evoked pain is not associated with pain at rest or physical function in knee osteoarthritis’

European Journal of Pain, Journal Year: 2024, Volume and Issue: 28(6), P. 863 - 864

Published: March 11, 2024

Movement-evoked pain (MEP), or that occurs with is provoked by movement, prevalent in individuals knee osteoarthritis (KOA) and associated mobility impairment, clinical poor health outcomes (Butera et al., 2024). Recent studies literature reviews show MEP distinguishable from pain-at-rest (PAR) driven shared distinct mechanisms, underscoring the importance of studying assessing these constructs The article Lozano-Meca al. (2024), recently published European Journal Pain, entitled 'Movement-evoked not at rest physical function osteoarthritis', examined correlations between PAR, performance adults KOA. We commend authors for their work to distinguish also take this opportunity provide our methodological perspective on KOA clarify some misinterpretations own cited work. First, assertion associations PAR have been studied inaccurate; multiple recent relationship other musculoskeletal conditions (Fullwood 2021). Second, based cross-sectional analysis a relatively small sample (N = 59) minimally-to-moderately severe radiographic (KL grade ≤ II), concluded was (Lozano-Meca This may be interpreted as counterintuitive inconsistent prior propose several plausible reasons findings, which were highlighted authors. In study, operationalized occurring response four walking tasks While paper support definition 2021), we must limited during walking. Particular KOA, commonly report squatting, ascending/descending stairs, standing sitting position; indicating best characterized over variety are meaningful individual. Also, current study average low, implying flat surface provoke Having less movement movement-evoked hypoalgesia 2024) an important consideration discussed. Findings due measuring after each task rather than calculating aggregate score across all tasks, superior (Knox 2023). Interestingly, (average self-reported past 7 days) high, implies differential phenotypes represented. As authors, recall measures ability assess yet approach used study. Alternatively, suggest intensity while seated immediately baseline, allowing direct comparisons MEP. Prior investigating relied larger, more heterogeneous samples better representation varying severity. bring up point because employed (2024) predominantly minimal-moderate substantial proportion patients assistive devices typically allowed testing assessments, potentially influence functional thus need controlled ensure confidence findings. examining confounding factors including age, sex, race, KL score, body mass index socioeconomic status, biopsychosocial components pain. title states there no relationships found it interesting statistically significant, albeit small, 10 m walk test MEP, well recorded timed-up-and-go noted, negative correlation time surprising, suggests greater faster times. Upon further consideration, possible those using speeds experienced increased effort/exertion. Future MEP-related factors, such motivation perceived effort, additional information understand nuances function. Ultimately, contributes emerging science highlights consensus regarding definitions standardization provocation intended capture impact natural human movements authors' conclusion indeed both should considered optimizing management. However, findings caution research needed replicate its financial disclosures report.

Language: Английский

Response to the commentary by Johnson et al. on ‘Movement‐evoked pain is not associated with pain at rest or physical function in knee osteoarthritis’

European Journal of Pain, Journal Year: 2024, Volume and Issue: 28(6), P. 865 - 866

Published: May 9, 2024

As the authors of manuscript entitled 'Movement-evoked pain is not associated with at rest or physical function in knee osteoarthritis' (Lozano-Meca et al., 2024), recently published European Journal Pain, we have read recent publication commentary by Johnson al. (2024), and thank for their wise accurate comments on our manuscript. We hereby provide some clarifications that will certainly help potential readers and, turn, enhance scientific conceptualization movement-evoked (MEP, hereinafter). a matter fact, state 'the assertion associations between MEP PAR been studied KOA inaccurate; multiple studies examined this relationship other musculoskeletal conditions (Fullwood 2021)'. Indeed, background section manuscript, highlight fact has under different conditions: Fullwood (2021) reviewed, explored mapped an interesting scoping review focuses aspects construct, providing useful framework measurement MEP. In they 'only six explicitly tested statistical differences MEP'. Those focused solely temporomandibular disorders, neck peripheral neuropathic: solely, Lundblad (2008, 2012), research, set after total arthroplasty following related to osteoarthritis, but subjects currently affected KOA, which tangentially concerns substratum research. Thus, assumption sustained endorsed because relationships are explored, none them conditions. relation radiological severity analysed MEP, data Kellgren-Lawrence eminently informative descriptive due low sample size, issue prevented us from making more specific analyses controlling potentially confounding sociodemographic and/or clinical factors, already considered acknowledged within as one limitations study. Moreover, did focus causation association, stated throughout cross-sectional nature introduction study, also indicated (when describing MEP) 'more recently, it defined during walking', reference (2021). acknowledge mistake wrong since aforementioned definition corresponds linked intrinsic form movement extracted articles who concept 'pain movement'. apologize terminological respect. Finally, (2024) indicate comment 'having less hypoalgesia (Butera 2024) important consideration was discussed'. This aspect paramount importance that, unfortunately, were able include explore much regret, promising suggested Butera MEP-hypoalgesia last February 2024, prior (December 2023). obviously follow pathway marked further would like close letter thanking well fundamental contribution conceptually scientifically building construct improve deeper understanding its mechanisms globally, specifically future cornerstone paradigm management. Our gratitude

Language: Английский