Size‐Dependent Acoustophoresis in Rectangular Microchannels: Critical Particle Radius and Multidimensional Field Coupling Effects

Electrophoresis, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

ABSTRACT Particle manipulation using acoustophoresis has emerged as a pivotal technology in microsystems engineering, garnering significant attention across soft matter physics, biomedical diagnostics, and lab‐on‐a‐chip applications. The operational efficacy of acoustofluidic tweezers platforms hinges on the precise control critical particle size threshold that governs transition between radiation‐force‐dominated trapping streaming‐mediated transport. Through systematic numerical investigations rectangular microchannels with two‐dimensional (2D) confinement, this study establishes quantitative correlations radius thresholds geometric parameters coupled standing‐wave fields. demarcates two distinct transport regimes: (i) Supercritical particles () achieve stable nodal via dominant radiation forces, independent initial spatial distribution; (ii) subcritical undergo continuous advection through streaming vortices. Our multiphysics framework combines finite element modeling analytical validation boundary‐layer force equilibrium analysis, revealing three key findings: First, confinement induces characteristic scaling laws ( being channel size) for one‐dimensional (1D) standing waves, confirmed parametric studies (: 0.1–5.1 mm). Second, 1D models maintain predictive accuracy (with discrepancies ) systems wavelength ratios or , but fail coupled‐mode fields where maximum reach . Third, orthogonal wave superposition 2D configurations reduces by suppressing velocities, particularly at These insights advance fundamental understanding size‐selective while providing engineering guidelines performance optimization acoustic design.

Language: Английский

Single cell RNA-seq: a novel tool to unravel virus-host interplay

VirusDisease, Journal Year: 2024, Volume and Issue: 35(1), P. 41 - 54

Published: March 1, 2024

Language: Английский