Vitamin K2 deficiency associated with short stature in children: a cross-sectional study DOI Creative Commons
Yanjie Shen,

G SHI,

Si Wen

et al.

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Short stature in children is a common concern that can result from various underlying conditions. While factors such as growth hormone deficiency and nutritional deficiencies are well-known contributors, the role of vitamin K2 (VK2) development short remains underexplored. This study aimed to investigate association between VK2 status children. A total 730 aged 3-16 years were enrolled divided into three groups: group (n = 191), near-short 357), normal 182). Clinical characteristics growth-related indicators including serum levels, bone mineral density (BMD), insulin-like factor 1 (IGF-1), 25-hydroxyvitamin D (25-(OH)D) collected. was analyzed both categorical variable (VK2 vs. status) continuous variable, logistic regression models applied assess using approaches. Correlations other also examined. The prevalence higher with (80.6%) (64.7%) compared those (32.4%) (P < 0.05). Multiple showed levels significantly associated decreased risk (aOR 0.005, 95% CI: 0.001-0.036) 0.023, 0.006-0.085); increased 5.934, 3.372-10.443) 3.233, 2.095-4.989) after adjusting for covariates. Additionally, positively correlated IGF-1-SDS 25(OH)D an Further longitudinal studies warranted elucidate causal relationship disorders pediatric populations.

Language: Английский

Vitamin K2 deficiency associated with short stature in children: a cross-sectional study DOI Creative Commons
Yanjie Shen,

G SHI,

Si Wen

et al.

BMC Pediatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Short stature in children is a common concern that can result from various underlying conditions. While factors such as growth hormone deficiency and nutritional deficiencies are well-known contributors, the role of vitamin K2 (VK2) development short remains underexplored. This study aimed to investigate association between VK2 status children. A total 730 aged 3-16 years were enrolled divided into three groups: group (n = 191), near-short 357), normal 182). Clinical characteristics growth-related indicators including serum levels, bone mineral density (BMD), insulin-like factor 1 (IGF-1), 25-hydroxyvitamin D (25-(OH)D) collected. was analyzed both categorical variable (VK2 vs. status) continuous variable, logistic regression models applied assess using approaches. Correlations other also examined. The prevalence higher with (80.6%) (64.7%) compared those (32.4%) (P < 0.05). Multiple showed levels significantly associated decreased risk (aOR 0.005, 95% CI: 0.001-0.036) 0.023, 0.006-0.085); increased 5.934, 3.372-10.443) 3.233, 2.095-4.989) after adjusting for covariates. Additionally, positively correlated IGF-1-SDS 25(OH)D an Further longitudinal studies warranted elucidate causal relationship disorders pediatric populations.

Language: Английский

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