Biocompatible microneedles with engineered indentation design fabricated via vat photopolymerization for enhanced transdermal drug delivery DOI

Aqila Che Ab Rahman,

Siyoung Yang,

Sooman Lim

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113818 - 113818

Published: Feb. 1, 2025

Language: Английский

Bio-gel nanoarchitectonics in tissue engineering DOI Creative Commons
Jingwen Song,

Wenyan Lyu,

Kohsaku Kawakami

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(28), P. 13230 - 13246

Published: Jan. 1, 2024

Nanoarchitectonics may be highly compatible with applications in biological systems. Construction strategies and functions of bio-gel nanoarchitectonics medical tissue engineering are discussed.

Language: Английский

Citations

10

Hydrophobic Association Hydrogel Enabled by Multiple Noncovalent Interactions for Wearable Bioelectronics in Amphibious Environments DOI
Peng Du,

Juan Wang,

Yu‐I Hsu

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1318 - 1332

Published: Feb. 1, 2024

Functionalized hydrogels integrating soft nature and electrical properties are of great significance for the development human–machine interfaces, smart wearable devices, biomimetics robotics. However, hydrogel-based flexible sensors inevitably utilized in aquatic environments, resulting swelling-induced inferior mechanical performance, skin-component delamination, monitoring malfunction. Herein, a multiple dynamic-bond-driven hydrophobic association hydrogel with reliable water resistance, robustness, stable property is proposed via "two-step" method including micellar copolymerization postsoaking strategy. Benefiting from electrostatic interacted segments formed by myristyl methacrylate presence cetyltrimethylammonium bromide micelles, transparent exhibits desirable antiswelling feature, excellent stretchability (∼1500% elongation), toughness (∼2.4 MJ·m–3). The synergistic mechanisms ultrasound dispersion endow repeatable wet-adhesion behaviors. Moreover, as-prepared possesses significant conductivity storage durability owing to chitosan chain entanglements, interactions, strong hydrogen bonding established sodium phytate. As demonstration, sensor fabricated transmit various human movement signals wirelessly monitor electrocardiography both air underwater based on its wide sensing range (∼500%) linear sensitivity. This study offers an effective strategy developing electronic systems amphibious scenarios.

Language: Английский

Citations

8

Hydrophobic Eutectogels as Electrodes for Underwater Electromyography Recording DOI Creative Commons

Jon López de Lacalle,

Matías L. Picchio, Antonio Dominguez‐Alfaro

et al.

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(12), P. 3340 - 3346

Published: Nov. 15, 2023

Underwater recording remains a critical challenge in bioelectronics because traditional flexible electrodes can not fulfill essential requirements such as stability and steady conductivity aquatic environments. Herein, we show the use of elastic gels made hydrophobic natural eutectic solvents water-resistant electrodes. These eutectogels are designed with tailorable mechanical properties via one-step photopolymerization acrylic monomers different mixtures composed fatty acids menthol. The low viscosity eutectics turns formulations into suitable inks for 3D printing, allowing fast manufacturing complex objects. Furthermore, nature building blocks endows excellent water uptake. obtained eutectogel record real-time electromyography (EMG) signals interference air underwater.

Language: Английский

Citations

20

Materials Nanoarchitectonics at Dynamic Interfaces: Structure Formation and Functional Manipulation DOI Open Access
Katsuhiko Ariga

Materials, Journal Year: 2024, Volume and Issue: 17(1), P. 271 - 271

Published: Jan. 4, 2024

The next step in nanotechnology is to establish a methodology assemble new functional materials based on the knowledge of nanotechnology. This task undertaken by nanoarchitectonics. In nanoarchitectonics, we architect material systems from nanounits such as atoms, molecules, and nanomaterials. terms hierarchy structure harmonization function, created nanoarchitectonics has similar characteristics organization biosystems. Looking at actual biofunctional systems, dynamic properties interfacial environments are key. other words, interfaces important for production bio-like highly systems. this review paper, will be discussed, looking recent typical examples. particular, basic topics “molecular manipulation, arrangement, assembly” “material production” discussed first two sections. Then, following section, “fullerene assembly: zero-dimensional unit advanced materials”, discuss how various structures can very nanounit, fullerene. above examples demonstrate versatile possibilities architectonics interfaces. last these tendencies summarized, future directions discussed.

Language: Английский

Citations

7

Tailor‐Made Gold Nanomaterials for Applications in Soft Bioelectronics and Optoelectronics DOI
Yujie Zhang, Yi Liu, Yuerui Lu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract In modern nanoscience and nanotechnology, gold nanomaterials are indispensable building blocks that have demonstrated a plethora of applications in catalysis, biology, bioelectronics, optoelectronics. Gold possess many appealing material properties, such as facile control over their size/shape surface functionality, intrinsic chemical inertness yet with high biocompatibility, adjustable localized plasmon resonances, tunable conductivity, wide electrochemical window, etc. Such attributes been recently utilized for designing fabricating soft bioelectronics This motivates to give comprehensive overview this burgeoning field. The discussion representative tailor‐made nanomaterials, including nanocrystals, ultrathin nanowires, vertically aligned hard template‐assisted nanowires/gold nanotubes, bimetallic/trimetallic nanomeshes, nanosheets, is begun. followed by the description various fabrication methodologies state‐of‐the‐art strain sensors, pressure electrophysiological devices, energy‐storage energy‐harvesting optoelectronics, others. Finally, remaining challenges opportunities discussed.

Language: Английский

Citations

7

Vinyl Polymers as Key Materials in Contact Lens Design: A Review of Progress and Future Directions DOI

Lina M. Shaker,

Ahmed A. Al‐Amiery, Wan Nor Roslam Wan Isahak

et al.

Starch - Stärke, Journal Year: 2024, Volume and Issue: 76(7-8)

Published: March 1, 2024

Abstract Vinyl polymers, crucial in contemporary contact lens design, present unique attributes with promising implications for vision correction. This comprehensive review navigates the trajectory and future trajectories of vinyl polymer‐based lenses. The introduction underscores vital role lenses correction positions polymers as ideal materials due to their exceptional properties. Delving into material specifics—high oxygen permeability, optical clarity, surface wettability, mechanical strength—the analysis emphasizes influence on corneal health, comfort, durability. versatility manufacturing techniques, encompassing spin casting, molding processes, polymerization, modification, feasibility crafting high‐quality Examining clinical applications, daily disposables, extended wear, silicone hydrogel, specialty lenses, alongside biocompatibility assessments user feedback, provides a nuanced understanding effectiveness. article candidly addresses challenges—dehydration, deposits, stability, durability—alongside regulatory considerations. Future prospects involve novel formulations, smart materials, bioinspired designs, noninvasive technologies amplify comfort performance. In conclusion, this distills progress, acknowledges challenges, charts sanguine course polymer advancing envisioning marked by enhanced technologies.

Language: Английский

Citations

6

Efficient Hospital Waste Treatment and Management Through IoT and Bioelectronics DOI
Shalom Akhai, Alex Khang

Advances in environmental engineering and green technologies book series, Journal Year: 2024, Volume and Issue: unknown, P. 126 - 140

Published: May 29, 2024

This chapter explores the challenges and risks of hospital waste management, highlighting potential IoT bioelectronics to improve treatment disposal. The integration these technologies can revolutionize reducing environmental impact meeting regulatory requirements. monitor generation rates, segregation, disposal, simplifying operations human intervention. Bioelectronics enhances by sensing analyzing materials, detecting infections other hazards in medical for efficient processing. By improving disposal processes, systems meet requirements reduce health concerns. data management plans, but security, infrastructure integration, cost must be considered during installation. Future advancements artificial intelligence machine learning could enhance through predictive analytics optimization. In conclusion, have transform efficiency, sustainability, compliance. Further research, innovation, cooperation are needed fully utilize technologies.

Language: Английский

Citations

6

Degradable and Recyclable Hydrogels for Sustainable Bioelectronics DOI

Lianghao Jia,

Yuanhong Li, Aobo Ren

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(26), P. 32887 - 32905

Published: June 21, 2024

Hydrogel bioelectronics has been widely used in wearable sensors, electronic skin, human-machine interfaces, and implantable tissue-electrode providing great convenience for human health, safety, education. The generation of waste from bioelectronic devices jeopardizes health the natural environment. development degradable recyclable hydrogels is recognized as a paradigm realizing next environmentally friendly sustainable bioelectronics. This review first summarizes wide range applications bioelectronics, including devices. Then, employment synthetic polymers hydrogel discussed terms degradability recyclability. Finally, this work provides constructive thoughts perspectives on current challenges toward valuable insights guidance future evolution

Language: Английский

Citations

6

Peptide-nanoparticle conjugates as a theranostic platform DOI Creative Commons
Suhyeon Kim, Young Hyun No, Ronald Sluyter

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 500, P. 215530 - 215530

Published: Nov. 9, 2023

Theranostic platforms have emerged as advanced systems integrating diagnostic and therapeutic agents to enable personalized medicine tailored the specific characteristics of each patient's disease. However, conventional theranostic strategies face challenges in achieving high specificity sensitivity for diagnosis therapy. This necessitates development novel improve accuracy efficacy. Peptide-nanoparticle conjugates (PNCs) recently gained attention promising cancer platforms, offering enhanced accuracy. PNCs combine favorable features nanoparticles with bioactivity, biocompatibility, multifunctionality peptides, overcoming individual material limitations synergistically controlling relevant biological activities. In this review, we explore potential highly effective accurate focusing on theranostics. We provide background information highlight benefits based their components. define key properties desired applications corresponding parameters property control. Representative examples PNC-based studies are presented these parameters. Lastly, propose guidelines designing through a nanoarchitectonics approach develop platform. research contributes advancement holds great improving patient outcomes treatment.

Language: Английский

Citations

14

Securing Smart Healthcare Cyber-Physical Systems against Blackhole and Greyhole Attacks Using a Blockchain-Enabled Gini Index Framework DOI Creative Commons

Mannan Javed,

Noshina Tariq, Muhammad Imran Ashraf

et al.

Sensors, Journal Year: 2023, Volume and Issue: 23(23), P. 9372 - 9372

Published: Nov. 23, 2023

The increasing reliance on cyber-physical systems (CPSs) in critical domains such as healthcare, smart grids, and intelligent transportation necessitates robust security measures to protect against cyber threats. Among these threats, blackhole greyhole attacks pose significant risks the availability integrity of CPSs. current detection mitigation approaches often struggle accurately differentiate between legitimate malicious behavior, leading ineffective protection. This paper introduces Gini-index blockchain-based Blackhole/Greyhole RPL (GBG-RPL), a novel technique designed for efficient health monitoring GBG-RPL leverages analytical prowess Gini index advantages blockchain technology sophisticated research not only focuses identifying anomalous activities but also proposes resilient framework that ensures reliability monitored data. achieves notable improvements compared another state-of-the-art referred BCPS-RPL, including 7.18% reduction packet loss ratio, an 11.97% enhancement residual energy utilization, 19.27% decrease consumption. Its features are very effective, boasting 10.65% improvement attack-detection rate 18.88% faster average time. optimizes network management by exhibiting 21.65% message overhead 28.34% end-to-end delay, thus showing its potential enhanced reliability, efficiency, security.

Language: Английский

Citations

12