COMPARATIVE EFFICACY AND SAFETY OF RUFINAMIDE AND VALPROIC ACID MONOTHERAPY IN EPILEPSY TREATMENT DOI Creative Commons

Khalid abdulaziz alkhudaydi,

Mohammed Abdullah Alqarni,

Adnan ayidh althobaiti

et al.

Published: Jan. 1, 2022

Background: It is a well-known fact that rufinamide and valproic acid (VPA) are antiepileptic drugs (AEDs) indicated for epilepsy, but there limited data to show their relative efficacy safety. This study evaluated compared against VPA as the monotherapy choice treatment of seizures. challenge identifying right each patient with epilepsy makes it one most difficult types neurological disorders diagnose correctly manage. Methods: The 132 patients between 18-65 years age partial-onset seizures were randomized two groups which first (n=66) received up 400 mg twice daily while second extended-release 1500 during 48 weeks period. endpoints seizure reduction by 28 days (at least 50% responders' rate) freedom at 6 months, both associated quality life. Safety tolerability final important aspects well. Results: Taking 12-week treatment, rufinamide's marked median percent in frequency much higher than VPA's (45.1 vs 33.4%; p<0.0001). While more subjects group had ≥50% decrease (52.9% 33.6%, p<0.001), latter still achieved significant outcomes. consequences caused grades life scores decrease. Adverse events often similar, discontinuations occurred due side effects (3.6% 4.4%). Conclusions: effectiveness RUF have terms control remains similar; however, Rufinamide efficient, being same cases. In case Rufinamide, effect positive, this medication well-tolerated epilepsy.

Language: Английский

Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic–clonic seizure model: an isobolographic transformation DOI Creative Commons
Jarogniew J. Łuszczki, Hubert Bojar, Katarzyna Jankiewicz

et al.

Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(6), P. 1533 - 1543

Published: Oct. 11, 2023

Abstract Background Overwhelming evidence indicates that some naturally occurring coumarins and terpenes are widely used in folk medicine due to their various therapeutic effects affecting the brain. Antiseizure medications (ASMs) principal treatment option for epilepsy patients, although novel strategies based on substances intensively investigated. This study was aimed at determining influence of isopimpinellin (ISOP—a coumarin) when administered either separately or combination with borneol (BOR—a monoterpenoid), antiseizure potencies four classic ASMs (carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), valproate (VPA)) mouse model maximal electroshock-induced (MES) tonic–clonic seizures. Materials Tonic–clonic seizures were evoked experimentally mice after systemic ( ip ) administration respective doses ISOP, BOR, ASMs. Interactions two-drug (ISOP + a ASM) three-drug BOR mixtures assessed isobolographically MES model. Results ISOP (administered alone) had no impact anticonvulsant Due isobolographic transformation data, VPA exerted an antagonistic interaction, whereas CBZ, PHT, PB produced additive interactions The combinations CBZ PHT interactions, while synergistic Conclusions most intriguing interaction VPA, which addition transition from antagonism synergy

Language: Английский

Citations

6
A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy DOI Creative Commons
Abdul Waris, Muhammad Siraj, Ayyaz Ali Khan

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(12), P. 3729 - 3757

Published: Nov. 1, 2024

Epilepsy affects more than 70 million individuals of all ages worldwide and remains one the most severe chronic noncommunicable neurological diseases globally. Several neurotransmitters, membrane protein channels, receptors, enzymes, and, recently noted, various pathways, such as inflammatory mTORC complexes, play significant roles in initiation propagation seizures. Over past two decades, developments have been made diagnosis treatment epilepsy. Various pharmacological drugs with diverse mechanisms action other options developed to control seizures treat These include surgical treatment, nanomedicine, gene therapy, natural products, nervous stimulation, a ketogenic diet, gut microbiota, etc., which are developmental stages. Despite plethora options, one-third affected resistant current medications, while majority approved side effects, changes can occur, pharmacoresistance, effects on cognition, long-term problems, drug interactions, risks poor adherence, specific for certain psychological complications. Therefore, development new that no or minimal adverse is needed combat this deadly disease. In Review, we comprehensively summarize explain stages epilepsy well their status clinical trials advancements.

Language: Английский

Citations

2
Perampanel’s forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy DOI Creative Commons
Michelle Guignet, Amanda Campbell,

Jonathan Vuong

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 20, 2023

Abstract Background Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy may be under-addressed clinical practice. Ethical concerns make it impossible study the impact of nonadherence trials, but our previous work emphasizes importance using preclinical approaches address these questions. With over 30 clinically available antiseizure medicines (ASM’s), remains an important question understand relationship between poor seizure incidence across mechanistically distinct ASM’s, including broad-spectrum ASM, perampanel (PER). Methods We formulated PER into chow pellets deliver rats a 100% fully adherent or 50% variable nonadherent paradigm via novel automated medication-in-food delivery system. Chronic oral dosing was initiated male chronic while monitoring 24/7 for videoEEG evidence seizures during 4-week placebo baseline treatment phase. concentrations were monitored plasma at 1-week intervals correlated degree control. The missed doses extended patterns breakthrough seizures. Results Fully demonstrated median reduction frequency 50%, whereas had increase 54%. Plasma stable period both groups, levels being twice as high animals. There no correlation single dose series However, those animals group that received every meal 24-h reduced likelihood incidence. Conclusions If data is supported clinic, PER’s favorable pharmacokinetic profile humans, combined lowered risk suggests provide certain forgiveness factor if within window.

Language: Английский

Citations

5
Current Pharmacological Management in Juvenile Huntington’s Disease DOI Open Access
Lisa Robertson,

Helen Santini,

Kirsty O’Donovan

et al.

PLoS Currents, Journal Year: 2012, Volume and Issue: 4, P. RRN1304 - RRN1304

Published: March 26, 2012

Background: The clinical presentation of Juvenile Huntington's Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management.Aim: To survey the current use pharmacological treatments for JHD.Methods: Patients were identified through Association, Hospital Doctors and European Network REGISTRY study.Results: most commonly prescribed agents anti-psychotics (24/45), anti-depressants (17/45) anti-parkinsonian medications (15/45).5 patients taking more than 8 medications.Conclusions: group medication was anti-psychotic.Many on multiple therapies, highlighting need rationalise medications.

Language: Английский

Citations

13
Paternal exposure to antiseizure medications and offspring outcomes: a systematic review DOI
Eliza Honybun, Genevieve Rayner, Charles B. Malpas

et al.

Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. jnnp - 334077

Published: Sept. 19, 2024

Background Concerns have recently been raised about risks to the fetus resulting from paternal exposure antiseizure medications (ASMs). To address these concerns, we conducted a systematic review of literature assess neurodevelopmental and anatomical outcomes in offspring born fathers taking ASMs at time conception. Methods Electronic searches MEDLINE, PsycINFO, Embase were identify human studies published English that reported on outcomes, comprising disorders, major congenital malformations, small-for-gestational age or low birth weight, Quality analysis included was undertaken using Newcastle-Ottawa Scale. A narrative synthesis used report study findings. Results Of 923 identified by search screened title abstract, 26 underwent full-text 10 met eligibility criteria. There limited evidence available, but there appeared be no clear for an adverse impact ASM use outcomes. Few isolated findings not replicated other investigations. Several methodological limitations prevented meta-analysis, including failure most separately each individual ASM, heterogeneity measurement outcome reporting, small numbers monotherapy exposures. Conclusions Although data this provides reassuring conception is unlikely pose any risk offspring. Further research needed examine relationship between preconception males postnatally.

Language: Английский

Citations

1
Navigating the Depths: A Comprehensive Narrative Review on Depression in People with Epilepsy DOI Creative Commons
Norah A. AlKhaldi

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41389 - e41389

Published: Dec. 25, 2024

Language: Английский

Citations

1
Proceedings of the “International Congress on Structural Epilepsy & Symptomatic Seizures” (STESS, Gothenburg, Sweden, 29–31 March 2023) DOI
Francesco Brigo, Johan Zelano, Laura Abraira

et al.

Epilepsy & Behavior, Journal Year: 2023, Volume and Issue: 150, P. 109538 - 109538

Published: Nov. 30, 2023

Language: Английский

Citations

1
Adherence to Epilepsy’s Medical Recommendations DOI Creative Commons

Anna Jopowicz,

Agnieszka Piechal, Elżbieta Bronisz

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 255 - 255

Published: March 5, 2024

The primary problem in the treatment of epilepsy is poor seizure control. Several studies have shown that non-adherence to doctors’ recommendations regarding drug dosage, time administration as well lifestyle modifications are most frequent causes persistence or reoccurrence seizures, other than cases misdiagnosis and selection. aim this study was assess prevalence non-compliance with medical recommendations, both relation medicine regularity lifestyle, also determine factors affecting patients diagnosed epilepsy. This carried out on a total 169 who were under care an outpatient neurology clinic. assessment compliance performed using Patient Rating Compliance Scale (PRCS), Clinician (CRS) authors’ scale. Depending scale used, varying degrees noted. They follows—65.3% scale, 10% PRCS 9% CRS. following influenced recommendations: type epilepsy, consumption alcoholic beverages, frequency follow-up visits clinic, pharmacotherapy number medicines taken.

Language: Английский

Citations

0
Seizure recurrence following the first unprovoked seizure: Risk factors among children in UAE DOI

Dina Amin Saleh,

Abeera Hassan

International Journal of Developmental Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract In a retrospective study of paediatric and adolescent patients in Abu Dhabi, UAE, who experienced their first unprovoked seizure between March 2016 2020, with minimum one‐year follow‐up, we identified significant risk factors associated recurrence. Among 317 patients, 96.2% recurrence, the majority (68.8%) occurring within 6‐month follow‐up period. Notable for recurrence included focal seizures, symptomatic causes, abnormal initial electroencephalogram (EEG) findings, brain magnetic resonance imaging results, presence neurological disorders. Interestingly, type epileptiform activity EEG did not predict risk. Over 3‐year period, overall was 98.4%, particularly higher cases seizures compared to idiopathic (genetic) ones. These findings underscore importance vigilant monitoring, early post‐seizure advocate assessments, especially remote seizures.

Language: Английский

Citations

0
Generation and Characterization of Three Novel Mouse Mutant Strains Susceptible to Audiogenic Seizures DOI Creative Commons
Elena G. Varlamova,

Vera P. Kuldaeva,

Natalia Mitina

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1747 - 1747

Published: Oct. 22, 2024

The mechanisms of epileptogenesis after brain injury, ischemic stroke, or tumors have been extensively studied. As a result, many effective antiseizure drugs developed. However, there are still patients who resistant to therapy. molecular and genetic bases regarding such drug-resistant seizures poorly elucidated. In cases, heavy instigated by development malformations often caused gene mutations. Such can be demonstrated in mouse models generating mutant strains. One the most potent mutagens is ENU (N-ethyl-N-nitrosourea). present study, we describe three novel strains generated ENU-directed mutagenesis. Two these very strong epileptic phenotype triggered audiogenic stimuli (G9-1 S5-1 strains). third strain characterized behavioral disorders hyperexcitation neuronal networks. We identified changes expression those genes encoding neurotransmission proteins cerebral cortexes mice. It turned out that G9-1 strongest disruptions plasma membrane channels, excitatory glutamate receptors, protein kinases. On other hand, number GABAergic neurons was also affected mutation. All lines increased anxiety, excitability, suppressed motor orientational-exploratory activities. with an phenotype-G9-1 S5-1ave reduced learning ability, A9-2 mice line retains high ability.

Language: Английский

Citations

0