How are Humans Exposed to Organic Chemicals Released to Indoor Air?

Environmental Science & Technology, Journal Year: 2019, Volume and Issue: 53(19), P. 11276 - 11284

Published: Sept. 9, 2019

Humans are exposed to organic chemicals released indoor air through near-field exposure routes such as inhalation and nondietary dust ingestion well far-field consumption of food. Here, we explore the relative importance near- its variability between chemicals, age groups, subpopulations, by modeling aggregate human indoor-released with diverse partitioning behavior degradability. Our model results indicate that if assumed be perfectly persistent, dietary dominates hydrophobic relatively low volatility (with an octanol-air partition coefficient KOA > 106.5 octanol-water KOW < 1011), whereas volatile chemicals. Other routes, for example, dermal absorption drinking water, make a small contribution exposure. Reduced chemical persistence in environmental media biota lowers ingestion. For most other than those 109 1012 106 (e.g., polybrominated diphenyl ethers), is primarily governed degradability rather age- population-dependent factors.

Language: Английский

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Distribution, sources and human risk of perfluoroalkyl acids (PFAAs) in a receiving riverine environment of the Nanjing urban area, East China

Journal of Hazardous Materials, Journal Year: 2019, Volume and Issue: 381, P. 120911 - 120911

Published: July 19, 2019

Language: Английский

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Recommendations for Improving Methods and Models for Aquatic Hazard Assessment of Ionizable Organic Chemicals

Environmental Toxicology and Chemistry, Journal Year: 2019, Volume and Issue: 39(2), P. 269 - 286

Published: Oct. 1, 2019

Ionizable organic chemicals (IOCs) such as acids and bases are an important substance class requiring aquatic hazard evaluation. Although the toxicity of IOCs is highly dependent on water pH, many studies in literature cannot be interpreted because pH was not reported or kept constant during experiment, calling for adaptation improvement testing guidelines. The modulating influence mainly caused by pH-dependent uptake bioaccumulation IOCs, which can described ion-trapping toxicokinetic models. internal effect concentrations were found to independent external organisms' cells' ability maintain a stable milieu. If close existing quantitative structure-activity relationships (QSARs) neutral organics adapted substituting octanol-water partition coefficient ionization-corrected liposome-water distribution ratio hydrophobicity descriptor, demonstrated modification target lipid model. Charged, zwitterionic species IOC all contribute observed toxicity, either through concentration-additive mixture effects interaction different species, case uncoupling mitochondrial respiration. For specifically acting we recommend 2-step screening procedure with ion-trapping/QSAR models used predict baseline followed adjustment using toxic derived from vitro systems. Receptor- plasma-binding also show promise elucidating toxicity. present review intended help demystify ecotoxicity provide recommendations their risk assessment. Environ Toxicol Chem 2020;39:269-286. © 2019 Authors. Environmental Toxicology Chemistry published Wiley Periodicals, Inc. behalf SETAC.

Language: Английский

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Psychoactive pharmaceuticals in aquatic systems: A comparative assessment of environmental monitoring approaches for water and fish

Environmental Pollution, Journal Year: 2020, Volume and Issue: 261, P. 114150 - 114150

Published: Feb. 7, 2020

Language: Английский

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Bioaccumulation of per- and polyfluoroalkyl substance in fish from an urban river: Occurrence, patterns and investigation of potential ecological drivers

Environmental Pollution, Journal Year: 2022, Volume and Issue: 303, P. 119165 - 119165

Published: March 16, 2022

Language: Английский

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