High-Efficiency Effect-Directed Analysis Leveraging Five High Level Advancements: A Critical Review

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(23), P. 9925 - 9944

Published: May 31, 2024

Organic contaminants are ubiquitous in the environment, with mounting evidence unequivocally connecting them to aquatic toxicity, illness, and increased mortality, underscoring their substantial impacts on ecological security environmental health. The intricate composition of sample mixtures uncertain physicochemical features potential toxic substances pose challenges identify key toxicants samples. Effect-directed analysis (EDA), establishing a connection between found samples associated hazards, enables identification that can streamline research efforts inform management action. Nevertheless, advancement EDA is constrained by following factors: inadequate extraction fractionation samples, limited bioassay endpoints unknown linkage higher order impacts, coverage chemical (i.e., high-resolution mass spectrometry, HRMS), lacking effective bioassays analysis. This review proposes five advancements enhance efficiency addressing these challenges: (1) multiple adsorbents for comprehensive extraction, (2) microfractionation multidimensional refined fractionation, (3) robust vivo/vitro omics, (4) high-performance configurations HRMS analysis, (5) chemical-, data-, knowledge-driven approaches streamlined toxicant validation. We envision future will integrate big data artificial intelligence based development quantitative cutting-edge microfractionation, ultraperformance MS hazard factors, serving broader governance.

Language: Английский

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An assessment and characterization of pharmaceuticals and personal care products (PPCPs) within the Great Lakes Basin: Mussel Watch Program (2013–2018)

Environmental Monitoring and Assessment, Journal Year: 2024, Volume and Issue: 196(4)

Published: March 5, 2024

Abstract Defining the environmental occurrence and distribution of chemicals emerging concern (CECs), including pharmaceuticals personal care products (PPCPs) in coastal aquatic systems, is often difficult complex. In this study, 70 compounds representing several classes pharmaceuticals, antibiotics, anti-inflammatories, insect repellant, antibacterial, antidepressants, chemotherapy drugs, X-ray contrast media compounds, were found dreissenid mussel (zebra/quagga; Dreissena spp.) tissue samples. Overall concentration detection frequencies varied significantly among sampling locations, site land-use categories, sites sampled proximate downstream point source discharge. Verapamil, triclocarban, etoposide, citalopram, diphenhydramine, sertraline, amitriptyline, DEET (N,N-diethyl-meta-toluamide) comprised most ubiquitous PPCPs (> 50%) detected mussels. Among those quantified tissue, metformin, methylprednisolone, hydrocortisone, 1,7-dimethylxanthine, theophylline, zidovudine, prednisone, clonidine, 2-hydroxy-ibuprofen, iopamidol, melphalan at concentrations up to 475 ng/g (wet weight). Antihypertensives, antidepressants accounted for majority tissue. The results showed that mussels are occurring as complex mixtures, with 4 28 one or more locations. magnitude composition highest not influenced by either WWTP CSO discharge (i.e., non-WWTPs), strongly supporting non-point sources important drivers pathways study. As these inshore offshore findings study indicate their persistence potential risks largely unknown, thus warranting further assessment prioritization contaminants Great Lakes Basin. Graphical

Language: Английский

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Combined Exposures and Mixtures Research: An Enduring NIEHS Priority

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(7)

Published: July 1, 2024

The National Institute of Environmental Health Sciences (NIEHS) continues to prioritize research better understand the health effects resulting from exposure mixtures chemical and nonchemical stressors. Mixtures activities over last decade were informed by expert input during development deliberations 2011 NIEHS Workshop "Advancing Research on Mixtures: New Perspectives Approaches for Predicting Adverse Human Effects." efforts since then have focused key themes including

Language: Английский

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Derivation and characterization of environmental hazard concentrations for chemical prioritization: a case study in the Great Lakes tributaries

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Ongoing anthropogenic activities and analytical advancements yield continuously expanding lists of environmental contaminants. This represents a challenge to managers, who must prioritize chemicals for management actions (e.g., restriction, regulation, remediation) but are often hindered by resource limitations. To help facilitate prioritization efforts, this study presents several strategies deriving hazard concentrations using publicly accessible data open-source computational tools. Using Great Lakes tributaries aquatic monitoring dataset as case study, were obtained or derived 334 organic chemicals. These based on (1) current water quality guidelines; (2) apical screening values; (3) (4) nonapical effect from the ECOTOXicology Knowledgebase; (5) in vitro ToxCast database; (6) cytotoxic burst collated Comptox Dashboard; (7) “estimated values” modeled estimated available various regulatory nonregulatory agencies; (8) pharmaceutical potency estimates MaPPFAST (9) quantitative structure-activity relationship (QSAR)–derived acute toxicity estimates. Environmental fate included half-lives bioconcentration factors Dashboard QSARs. identify patterns that could be used characterization, availability ecotoxicological evaluated. Furthermore, exceedances evaluated compared across diverse types. Altogether, providing detailed methodology practical examples generated with real data, demonstrated these concentration derivation can efficiently effectively large, complex datasets identified critical considerations future efforts.

Language: Английский

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Toxicology and Risk Assessment of Combined Chemicals and Nonchemical Stressors

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Estrogenic activity and acute toxicity assessments of sediments from a chronically polluted estuarine area in southeastern Brazil

Environmental Quality Management, Journal Year: 2023, Volume and Issue: 33(3), P. 183 - 194

Published: Sept. 27, 2023

Abstract Compounds displaying estrogenic potential can lead to serious negative aquatic ecosystem impacts, and exposure mixtures of endocrine disruptors present in environmental matrices with very complex characteristics, including sediments, cause risks biota, animals, humans. Within this perspective, the aim study was assess activity toxicity sediments sampled from Guanabara Bay, most important, although chronically polluted, estuary southeastern Brazil. To end, determinations were performed by yeast estrogen screen (YES) assay, acute assays carried out employing Vibrio fischeri . Estrogenic quantified up for 8.7 ng g −1 E2‐EQ, high levels cytotoxicity (up 95%) observed might have hindered determination real samples. Acute V. ranged 0 45.21%. These results point deleterious effects caused micropollutants underline urgency continuous monitoring degradation degree Bay estuary.

Language: Английский

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Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application

Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 42(12), P. 2506 - 2518

Published: Aug. 29, 2023

Assessing the ecological risk of contaminants in field typically involves consideration a complex mixture compounds which may or not be detected via instrumental analyses. Further, there are insufficient data to predict potential biological effects many compounds, leading their being characterized as emerging concern (CECs). Over past several years, advances chemistry, toxicology, and bioinformatics have resulted variety concepts tools that can enhance pragmatic assessment CECs. The present Focus article describes 10+- year multiagency effort supported through U.S. Great Lakes Restoration Initiative assess occurrence implications CECs North American Lakes. State-of-the-science methods models were used evaluate more than 700 sites about approximately 200 tributaries across lakes Ontario, Erie, Huron, Michigan, Superior, sometimes on multiple occasions. Studies featured measurement up 500 different target analytes environmental matrices, coupled with evaluation resident species, animals from situ laboratory exposures, vitro systems. Experimental taxa included birds, fish, invertebrates, measured endpoints ranged molecular apical responses. Data integrated evaluated using diversity curated knowledgebases goal producing actionable insights for assessors managers charged evaluating mitigating This overview is based research captured 90 peer-reviewed journal articles reports, including 30 appearing virtual issue comprised highlighted papers published Environmental Toxicology Chemistry Integrated Assessment Management. Environ Toxicol Chem 2023;42:2506-2518. © 2023 SETAC. has been contributed by Government employees work public domain USA.

Language: Английский

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Implications of biotic factors for toxicity testing in laboratory studies

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168220 - 168220

Published: Nov. 2, 2023

Language: Английский

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