Journal of The Electrochemical Society,
Journal Year:
2024,
Volume and Issue:
171(3), P. 037520 - 037520
Published: March 8, 2024
The
fields
of
biosensing
have
been
transformed
by
the
discovery
extraordinary
molecular
recognition
components,
such
as
aptamers
and
biomimetic
receptors.
Systematic
Evolution
Ligands
Exponential
Enrichment
(SELEX)
is
a
method
used
to
select
aptamers,
or
short
sequences
single-stranded
DNA
(ssDNA)
RNA
(ssRNA),
based
on
their
unique
binding
affinity
target
molecules.
Molecularly
imprinted
polymers
(MIPs)
are
type
receptor
that
mimics
selectivity
natural
receptors
inside
synthetic
matrix.
They
make
it
possible
identify
pathogens,
illness
biomarkers
with
accuracy.
Aptamers
play
crucial
roles
in
various
including
diagnostics,
therapeutics,
biosensing.
Their
high
specificity,
versatility,
adaptability
enable
targeted
detection,
drug
delivery,
biomolecule
manipulation,
thereby
contributing
advancements
personalized
medicine,
biotechnology,
disease
diagnosis.
combined
cutting-edge
technologies,
like
nanotechnology
lab-on-a-chip
systems,
create
biosensors
quick,
portable,
extremely
sensitive.
These
features
anticipated
become
more
important
technology
develops,
helping
address
global
issues,
advance
capabilities,
raise
people’s
standard
living
everywhere.
Recent
innovation
Biomimetic
Receptors
Biosensing
discussed
this
review
article.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(3)
Published: May 11, 2023
Nano-biosensors
that
are
composed
of
recognition
molecules
and
nanomaterials
have
been
extensively
utilized
in
disease
diagnosis,
health
management,
environmental
monitoring.
As
a
type
nano-biosensors,
molecular
specificity
field-effect
transistor
(FET)
biosensors
with
signal
amplification
capability
exhibit
prominent
advantages
including
fast
response
speed,
ease
miniaturization,
integration,
promising
their
high
sensitivity
for
detection
identification.
With
intrinsic
characteristics
stability
structural
tunability,
aptamer
has
become
one
the
most
commonly
applied
biological
units
FET
sensing
fields.
This
review
summarizes
recent
progress
based
on
functionalized
medical
diagnosis
The
structure,
principles,
preparation
methods,
functionalization
strategies
modified
were
comprehensively
summarized.
relationship
between
structure
performance
was
reviewed.
Furthermore,
challenges
future
perspectives
also
discussed,
so
as
to
provide
support
development
efficient
healthcare
management
monitoring
devices.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(21), P. 8665 - 8673
Published: May 9, 2024
Prostate-specific
antigen
(PSA)
is
a
key
marker
for
prostate
cancer
diagnosis.
The
low
sensitivity
of
traditional
lateral
flow
immunoassay
(LFIA)
methods
makes
them
unsuitable
point-of-care
testing.
Herein,
we
designed
nanozyme
by
in
situ
growth
Prussian
blue
(PB)
within
the
pores
dendritic
mesoporous
silica
(DMSN).
PB
was
forcibly
dispersed
into
DMSN,
leading
to
an
increase
exposed
active
sites.
Consequently,
atom
utilization
enhanced,
resulting
superior
peroxidase
(POD)-like
activity
compared
that
cubic
PB.
Antibody-modified
DMSN@PB
nanozymes
serve
as
immunological
probes
enzymatic-enhanced
colorimetric
and
photothermal
dual-signal
LFIA
PSA
detection.
After
systematic
optimization,
based
on
successfully
achieves
4-fold
amplification
signal
7
min
through
catalytic
oxidation
chromogenic
substrate
POD-like
activity.
Moreover,
exhibits
excellent
conversion
ability
under
808
nm
laser
irradiation.
Accordingly,
signals
are
introduced
improve
anti-interference
LFIA,
exhibiting
wide
linear
range
(1–40
ng
mL–1)
detection
limit
(0.202
mL–1),
which
satisfies
early
level
cancer.
This
research
provides
more
accurate
reliable
visualization
analysis
methodology
diagnosis
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(30), P. 39857 - 39866
Published: July 17, 2024
Total
antioxidants
play
a
crucial
role
in
human
health,
and
detection
of
the
total
antioxidant
capacity
(TAC)
has
broad
application
prospects
fields
such
as
food
safety,
environmental
assessment,
disease
diagnosis.
However,
long
time,
cumbersome
steps,
high
cost,
reliance
on
professional
equipment,
nonportability
still
remain
significant
challenges.
In
this
work,
an
efficient
strategy
point-of-care
testing
(POCT)
TAC
body
fluids
by
nanozyme-catalyzed
colorimetric
paper-based
microfluidic
sensors
is
proposed.
The
coupled
with
smartphone
can
reduce
costs
provide
portability.
nanozyme
prepared
solvothermal
method
presents
Michaelis
constants
0.11
0.129
mM
for
H2O2
TMB,
respectively.
A
immobilizing
nanozymes
chromogenic
agents
chip
established.
Based
photography
image
grayscale
extraction,
be
qualitatively
detected
limit
linear
range
33.4
50-700
μM,
Furthermore,
proposed
sensor
realize
one-step
quantitative
analysis
(blood,
saliva,
sweat)
within
15
min.
presented
study
exhibit
promising
biochemical
POCT.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(43), P. 22477 - 22503
Published: Oct. 17, 2024
The
porous
materials
known
as
metal-organic
frameworks
(MOFs)
stand
out
for
their
enormous
surface
area,
adaptable
pore
size
and
shape,
structural
variety.
These
characteristics
make
them
well-suited
various
applications,
especially
in
healthcare.
This
review
thoroughly
summarizes
recent
studies
on
the
use
of
MOFs
drug
delivery,
biosensing,
therapeutics.
may
encapsulate
medications,
target
certain
cells
or
tissues,
regulate
release
over
time.
Additionally,
have
potential
to
be
used
biosensing
allowing
selective
detection
chemical
biological
substances.
MOFs'
optical
electrical
modified
biosensors
that
track
physiological
data.
show
targeted
delivery
regulated
therapeutic
substances
cancer
treatment.
In
addition,
they
work
potent
antibacterial
agents,
providing
a
less
dangerous
option
than
traditional
antibiotics
increase
antibiotic
resistance.
For
practical
further
research
is
required
well
more
consideration
problems
with
toxicity
biocompatibility.
addition
addressing
difficulties
promising
possibilities
this
study
intends
provide
insights
into
healthcare
Despite
several
essential
reviews
it
was
necessary
look
most
therapy
combined
concept.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(9)
Published: Nov. 27, 2023
Abstract
A
wearable
sensor
capable
of
directly
detecting
cytokines
in
external
secretions
to
the
human
body
is
pivotal
for
gauging
intensity
immune
response
and
circumventing
inflammatory
storms,
a
significant
clinical
concern.
The
detection
low‐concentration
often
hampered
due
interference
from
impurities
secretions.
Addressing
this
challenge,
system
developed
by
integrating
Janus
membrane
with
water
auto‐collection/filtering
capabilities,
aptamer‐modified
graphene
field‐effect
transistor
sensors,
enabling
undiluted
sweat
samples.
can
automatically
filter
transport
them
surface,
effectively
eliminating
impurity
enhancing
sensor's
capabilities.
device
sensitively
detect
(such
as
TNF‐α,
marker
inflammation
cancer)
sweat,
range
spanning
0.5
500
pM,
limit
reaching
0.31
pM.
ultra‐flexibility
also
verified,
maintaining
stable
electrical
properties
even
after
enduring
up
50
extreme
deformations.
These
findings
indicate
that
has
potential
realize
monitoring
patients,
assist
healthcare
controlling
body's
status.
ACS Synthetic Biology,
Journal Year:
2025,
Volume and Issue:
14(1), P. 21 - 40
Published: Jan. 6, 2025
The
field
of
healthcare
diagnostics
is
navigating
complex
challenges
driven
by
evolving
patient
demographics
and
the
rapid
advancement
new
technologies
worldwide.
In
response
to
these
challenges,
biosensors
offer
distinctive
advantages
over
traditional
diagnostic
methods,
such
as
cost-effectiveness,
enhanced
specificity,
adaptability,
making
their
integration
with
point-of-care
(POC)
platforms
more
feasible.
recent
years,
aptasensors
have
significantly
evolved
in
capabilities
through
emerging
microfluidics,
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
(CRISPR)
systems,
wearable
devices,
machine
learning
(ML),
driving
progress
precision
medicine
global
solutions.
Moreover,
advancements
not
only
improve
accuracy
but
also
hold
potential
revolutionize
early
detection,
reduce
costs,
outcomes,
especially
resource-limited
settings.
This
Account
examines
key
advancements,
focusing
on
how
scientific
breakthroughs,
including
artificial
intelligence
(AI),
improved
sensitivity
precision.
Additionally,
has
enabled
real-time
monitoring
data
analysis,
fostering
advances
personalized
healthcare.
Furthermore,
commercialization
aptasensor
could
increase
availability
clinical
settings
support
use
widespread
solutions
for
health
challenges.
Hence,
this
review
discusses
technological
improvements,
practical
uses,
prospects
while
surrounding
standardization,
validation,
interdisciplinary
collaboration
application.
Finally,
ongoing
efforts
address
are
ensure
that
can
be
effectively
implemented
diverse
systems.
