Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)
Published: Feb. 21, 2025
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 3(4)
Published: July 2, 2023
Abstract Adoptive cell therapy (ACT) is a rapidly growing anti‐cancer strategy that has shown promise in treating various cancer types. The concept of ACT involves activating patients’ own immune cells ex vivo and then transferring them back to the patients recognize eliminate cells. Currently, commonly used includes tumor‐infiltrating lymphocytes (TILs), genetically engineered cells, dendritic (DCs) vaccines. With advancement culture genetic engineering techniques, been clinics treat malignant hematological diseases many new ACT‐based regimens are different stages clinical trials. Here, representative approaches introduced opportunities challenges for translation discussed.
Language: Английский
Citations
47
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 29, 2024
Abstract The immune system in humans is a defense department against both exogenous and endogenous hazards, where CD8 + T cells play crucial role opposing pathological threats. Various immunotherapies based on have emerged recent decades, showing their promising results treating intractable diseases. However, the fight constantly changing evolving cancers, formation function of can be challenged by tumors that might train group accomplices to resist cell killing. As cancer therapy stepped into era immunotherapy, understanding physiological cells, studying machinery tumor escape, thereby formulating different therapeutic strategies become imperative missions for clinical translational researchers fulfill. After brief basics cell-based biology covered, this review delineates mechanisms escape discusses immunotherapy regimens with own advantages setbacks, embracing challenges perspectives near future.
Language: Английский
Citations
26
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 16, 2024
Abstract Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer‐related death because immunosuppressive tumor microenvironment (TME) limits its therapeutic efficacy. Gasdermin (GSDM)‐mediated pyroptosis a new programmed cell that can boost antitumor immune responses. However, inducing efficient reverse TME challenging. Herein, layered double hydroxide‐coated magnesium (Zn‐LDH@Mg) implants are designed and constructed as alternating magnetic field (AMF)‐activated inducers induce highly effective in cancer cells. The powerful eddy‐thermal effects Zn‐LDH@Mg markedly amplify malignant cells through Caspase‐1/GSDMD‐dependent canonical pathway. Moreover, Mg 2+ synergistically activate T (especially CD8 + cells) enhance infiltration immune‐supportive This innovative strategy not only significantly suppresses proliferation primary but also stimulates response further efficacy checkpoint inhibitors impede progression distant tumors. work emphasizes importance surface engineering strategies for preparation novel highlights effectiveness reversing immunotherapy, providing approach rational design bioactive materials increase immunotherapy.
Language: Английский
Citations
11
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)
Published: Jan. 17, 2024
In the past decade, adoptive cell therapy with chimeric antigen receptor-T (CAR-T) cells has revolutionized cancer treatment. However, complexity and high costs involved in manufacturing current greatly inhibit its widespread availability access. To address this, situ therapy, which directly reprograms immune inside body, recently been developed as a promising alternative. Here, an overview of recent progress development synthetic nanomaterials is provided to deliver plasmid DNA or mRNA for reprogramming T macrophages, focusing especially on CAR therapies. Also, main challenges are discussed some approaches overcome these barriers fulfill clinical applications proposed.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 17, 2025
High-grade serous ovarian cancer (HGSOC), the predominant subtype of epithelial cancer, is frequently diagnosed at an advanced stage due to its nonspecific early symptoms. Despite standard treatments, including cytoreductive surgery and platinum-based chemotherapy, significant improvements in survival have been limited. Understanding molecular mechanisms, immune landscape, drug sensitivity HGSOC crucial for developing more effective personalized therapies. This study integrates insights from immunology, profiling, analysis identify novel therapeutic targets improve treatment outcomes. Utilizing single-cell RNA sequencing (scRNA-seq), systematically examines tumor heterogeneity microenvironment, focusing on biomarkers influencing response activity, aiming enhance patient outcomes quality life. scRNA-seq data was obtained GEO database this study. Differential gene expression analyzed using ontology set enrichment methods. InferCNV identified malignant cells, while Monocle, Cytotrace, Slingshot software inferred differentiation trajectories. The CellChat package predicted cellular communication between cell subtypes other pySCENIC utilized transcription factor regulatory networks within subtypes. Finally, results were validated through functional experiments, a prognostic model developed assess prognosis, infiltration, across various risk groups. investigated scRNA-seq, their interactions microenvironment. We confirmed key role C2 IGF2+ HGSOC, which significantly associated with poor prognosis high levels chromosomal copy number variations. located terminal tumor, displaying higher degree malignancy close association IIIC tissue types. also metabolic pathways, such as glycolysis riboflavin metabolism, well programmed death processes. highlighted complex fibroblasts MK signaling pathway, may be closely related tumor-associated progression. Elevated PRRX1 connected impact disease progression by modulating transcription. A based demonstrated adverse outcomes, emphasizing importance infiltration clinical intervention strategies. oncology, immunotherapy, reveal mechanisms driving resistance. subtype, linked offers promising target future Emphasizing sensitivity, research highlights strategies life patients.
Language: Английский
Citations
2
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103470 - 103470
Published: March 7, 2025
Language: Английский
Citations
2
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 20, 2025
Melanoma is an aggressive type of skin cancer that arises from melanocytes, the cells responsible for producing pigment. In contrast to non-melanoma cancers like basal cell carcinoma and squamous carcinoma, melanoma more invasive. was distinguished by its rapid progression, high metastatic potential, significant resistance conventional therapies. Although it accounted a small proportion cases, accounts majority deaths caused due ability invade deep tissues, adapt diverse microenvironments, evade immune responses. These unique features highlighted challenges treating underscored importance advanced tools, such as single-cell sequencing, unravel biology develop personalized therapeutic strategies. Thus, we conducted analysis cellular composition within tumor tissues further subdivided into subpopulations. Through analyzing metabolic pathways, stemness genes, transcription factors (TFs) among in different phases (G1, G2/M, S) well between primary foci cells, investigated specific mechanisms underlying metastasis. We also revisited temporal trajectories subpopulations, identifying core subpopulation C0 SOD3 + cells. Our findings revealed close relationship pivotal oxidative pathways tissues. Additionally, analyzed prognostically relevant differentially expressed genes (DEGs) built predictive model associated with outcomes. selected gene IGF1 highest coefficient (coef) value analysis, experimentally validated essential function proliferation invasive metastasis melanoma. infiltration discovered critical roles played M1/M2 macrophages progression evasion. Furthermore, development malignant were closely various forms programmed death (PCD), including apoptosis, autophagic death, ferroptosis, pyroptosis. often resisted mechanisms, maintaining their growth inhibiting apoptosis evading death. Meanwhile, induction ferroptosis pyroptosis thought trigger responses helped suppress dissemination. A deeper understanding PCD provided foundation developing novel targeted therapies, potential enhance treatment efficacy. contributed prognostic models shed light on research directions concerning targets.
Language: Английский
Citations
1
ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(5)
Published: Feb. 1, 2025
Abstract Polyoxometalates (POM) are a class of inorganic metal oxides with distinctive structural characteristics, compositional versatility, high catalytic efficacy, and convenient storage properties. In recent years, POM have shown considerable potential for mimicking enzyme activities. Besides their biological activities, been demonstrated to possess the ability sense diseases perform synergistic therapies based on redox near‐infrared absorption Similar metallic nanoparticles organic materials, these clusters also exhibit photothermal imaging therapeutic Based this, current review focuses exclusively application in therapy tumors. Furthermore, advantages issues associated POM‐based nanomaterials tumor discussed analyzed.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 10, 2025
Over the past decades, significant progress has been made in understanding of non-small cell lung cancer (NSCLC) biology and tumor progression mechanisms, resulting development novel strategies for early detection wide-ranging care approaches. Since their introduction, over 20 years ago, targeted therapies with tyrosine kinase inhibitors (TKIs) have revolutionized treatment landscape NSCLC. Nowadays, remain gold standard many patients, but still they suffer from adverse effects, including unexpected toxicity intrinsic acquired resistance mutations, which lead to relapse. The adoption immune checkpoint (ICIs) 2015, offered exceptional survival benefits patients without targetable alterations. Despite this notable progress, challenges remain, as not all respond favorably ICIs, therapy can develop time. A crucial factor influencing clinical response immunotherapy is microenvironment (TME). TME pivotal orchestrating interactions between neoplastic cells system, growth outcomes. In review, we discuss how intricate relationship success survey current state intervention, a focus on forthcoming promising chimeric antigen receptor (CAR) T sets major obstacles CAR-T therapies, creating conditions that suppress response, inducing exhaustion. To enhance efficacy, specific efforts associated NSCLC, should definitely TME-related immunosuppression escape by combining blockades.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Chimeric antigen receptor (CAR)-T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and poor infiltration CAR-T cells significantly hinder efficacy therapies against tumors. Here, spatially distributed microneedle system (SDMNS) is developed that leverages bioorthogonal reactions to activate guide endogenous T tumors effective destruction. The SDMNS consists two dissolving microneedles, each loaded with complementary groups applied separately lymph nodes sites. One dibenzocyclooctyne (DBCO)-modified antibodies activates labels them in nodes. other microneedle, containing N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) glycometabolic labeling cells, chemotactic factor IP10, directly site. vivo studies demonstrate effectively directs migration activated into Through click reaction, DBCO-modified conjugate azide (N3)-modified eliciting robust antitumor immune responses durable memory. offers novel overcomes heterogeneity by facilitating directed cells.
Language: Английский
Citations
1