Radical‐Scavenging Violet Phosphorus Nanosheets for Attenuating Hyperinflammation and Promoting Infected Wound Healing DOI Creative Commons
Zhuo Dai, Qiang Li, Meng Dang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract Antibacterial therapy targeting the regulation of macrophage polarization may be a useful approach for normalizing immune environment and accelerating wound healing. Inspired by black phosphorus‐based nanoplatforms, more stable yet less‐explored violet phosphorus nanosheets (VPNSs) are expected to provide superior solution effectively combating bacterial infections. In this study, an average thickness 5–7 nm VPNSs fabricated through liquid‐phase exfoliation method serve as immunoregulatory dressing treatment infected wounds. attenuated excessive reactive oxygen species (ROS) reduced accumulation proinflammatory M1 macrophages, showing notable antioxidant anti‐inflammatory properties. Comprehensive RNA sequencing further elucidated potential mechanisms VPNSs, including modulation inflammatory response enzyme regulator activity. Additionally, inherent photothermal properties contributed significantly their antibacterial efficacy. When combined with near‐infrared laser irradiation, showed remarkable effectiveness in reducing infection‐related complications expediting healing skin models. The rapid promotion ROS clearance, polarization, hyperthermia generation underscores violet‐phosphorus‐based nanoplatforms clinically viable agents treating This study suggests that promising candidates clinical anti‐infective applications.

Language: Английский

Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections DOI Creative Commons
Panchanathan Manivasagan, Thavasyappan Thambi,

Ara Joe

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101292 - 101292

Published: April 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Language: Английский

Citations

45
Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives DOI Open Access

Jingai Jiang,

Xinyi Lv,

Huijuan Cheng

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 1 - 19

Published: Feb. 7, 2024

Language: Английский

Citations

40
Intelligent bacteria‐targeting ZIF‐8 composite for fluorescence imaging‐guided photodynamic therapy of drug‐resistant superbug infections and burn wound healing DOI Creative Commons
Xiaoxue Li, Wei Wang,

Qiuxia Gao

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: April 19, 2024

Abstract Infected burn wounds are characterized by persistent drug‐resistant bacterial infection coupled with an inflammatory response, impeding the wound‐healing process. In this study, intelligent nanoparticle system (CCM+TTD@ZIF‐8 NPs) was prepared using curcumin (CCM), aggregation‐induced emission luminogens (TTD), and ZIF‐8 for infection‐induced wound healing. The CCM+TTD@ZIF‐8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging pH response‐guided photodynamic therapy (PDT), anti‐inflammatory. positive charges of allowed targeting in infected wounds, thereby realizing emitting red at site upon blue light irradiation. pH‐responsive characteristics also enabled controllable CCM release onto site, promoting specific accumulation ROS outstanding bactericidal efficacy against Staphylococcus aureus (S. aureus) Pseudomonas aeruginosa (P. aeruginosa) strains vitro/in vivo. Additionally, due to excellent effect anti‐inflammatory properties combined irradiation, regeneration epidermal tissue, angiogenesis, collagen deposition achieved, accelerating healing process wounds. Therefore, multifunctional provides great potential

Language: Английский

Citations

35
Engineered Probiotic Bio‐heterojunction with Robust Antibiofilm Modality via “Eating” Extracellular Polymeric Substances for Wound Regeneration DOI

Miao Qin,

Xiumei Zhang, Haiyang Ding

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 25, 2024

The compact three-dimensional (3D) structure of extracellular polymeric substances (EPS) within biofilms significantly hinders the penetration antimicrobial agents, making biofilm eradication challenging and resulting in persistent biofilm-associated infections. To address this challenge, a solution is proposed: probiotic bio-heterojunction (P-bioHJ) combining Lactobacillus rhamnosus with MXene (Ti

Language: Английский

Citations

29
Metal organic framework-loaded biohybrid magnetic microrobots for enhanced antibacterial treatment DOI
Bo Gu, Jun Cai, Guanya Peng

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 685, P. 133295 - 133295

Published: Jan. 23, 2024

Language: Английский

Citations

20
Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms DOI
Wenqi Wang, Peng Gao,

Hengshuo Gui

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205

Published: Sept. 11, 2024

Language: Английский

Citations

18
Nanotechnology‐driven strategies to enhance the treatment of drug‐resistant bacterial infections DOI
Junjie Zhang,

Ming Liu,

Haiyang Guo

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract The misuse of antibiotics has led to increased bacterial resistance, posing a global public health crisis and seriously endangering lives. Currently, antibiotic therapy remains the most common approach for treating infections, but its effectiveness against multidrug‐resistant bacteria is diminishing due slow development new increase drug resistance. Consequently, developing a\ntimicrobial strategies improving efficacy combat infection become an urgent priority. emergence nanotechnology revolutionized traditional treatment, presenting opportunities refractory infection. Here we comprehensively review research progress in nanotechnology‐based antimicrobial delivery highlight diverse platforms designed target different resistance mechanisms. We also outline use combining with other therapeutic modalities enhance drug‐resistant infections. These innovative have potential susceptibility overcome Finally, challenges prospects application nanomaterial‐based combating are discussed. This article categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Therapeutic Approaches Drug Discovery Nanomedicine Infectious Disease

Language: Английский

Citations

14
Flexible nanoplatform facilitates antibacterial phototherapy by simultaneously enhancing photosensitizer permeation and relieving hypoxia in bacterial biofilms DOI Creative Commons

Qinglin Xu,

Qiang Li, Meng Ding

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 184, P. 313 - 322

Published: June 17, 2024

Antimicrobial phototherapy has gained recognition as a promising approach for addressing bacterial biofilms, however, its effectiveness is often impeded by the robust physical and chemical defenses of biofilms. Traditional antibacterial nanoplatforms face challenges in breaching extracellular polymeric substances barrier to efficiently deliver photosensitizers deep into Moreover, prevalent hypoxia within biofilms restricts success oxygen-reliant phototherapy. In this study, we engineered soft mesoporous organosilica nanoplatform (SMONs) incorporating polyethylene glycol (PEG), catalase (CAT), indocyanine green (ICG), forming SMONs-PEG-CAT-ICG (SPCI). We compared antimicrobial efficacy SPCI with more rigid nanoplatforms. Our results demonstrated that unique flexible mechanical properties enable it navigate through biofilm barriers, markedly enhancing ICG penetration methicillin-resistant Staphylococcus aureus (MRSA) Notably, murine subcutaneous MRSA infection model, showed superior pharmacokinetic benefits over counterparts. The embedded effectively converts excess H

Language: Английский

Citations

11
A self-supplied hydrogen peroxide and nitric oxide-generating nanoplatform enhances the efficacy of chemodynamic therapy for biofilm eradication DOI

Dongxu Jia,

Yi Zou, Yuheng Zhang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 20 - 29

Published: Aug. 22, 2024

Language: Английский

Citations

11
Stimuli‐Responsive NO Delivery Platforms for Bacterial Infection Treatment DOI
Yanling Hu, Meng Ding, Xinyi Lv

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)

Published: Aug. 22, 2024

The prevalence of drug-resistant bacterial infections has emerged as a grave threat to clinical treatment and global human health, presenting one the foremost challenges in medical care. Thus, there is an urgent imperative develop safe efficacious novel antimicrobial strategies. Nitric oxide (NO) recognized endogenous signaling molecule, which plays pivotal role numerous pathological processes. Currently, NO garnered significant interest antibacterial agent due its capability eradicate bacteria, disrupt biofilms, facilitate wound healing, all while circumventing emergence drug resistance. However, inherently unstable characteristic therapeutic gas renders controlled administration gases exceedingly challenging. Hence, this review, current challenge infection discussed; then it briefly elucidated mechanism comprehensively delineate recent advancements stimulus-responsive delivery platforms, along with their merits, obstacles, prospective avenues for application. This review offers guidance future NO-medicated anti-infection therapy hoped.

Language: Английский

Citations

11