Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Dec. 25, 2024
Abstract
Oral
formulation
is
the
ideal
treatment
method
for
inflammatory
bowel
disease
(IBD)
therapy,
but
mucosal
damage
and
diarrhea
symptoms
impede
drug
retention
around
region,
severely
limiting
IBD
therapeutic
efficacy.
To
address
this,
an
oral
astaxanthin
(Ast)
precise
delivery
developed
with
selective
Ast
anchoring
region
by
novel
lactoferrin
(LF)‐responsive
flocculation.
This
also
heightens
apparent
solubility
of
minimized
edible
safety
risks
raw
materials.
For
in
vivo
exhibits
remarkable
outcomes,
including
a
significant
increase
colon
length
100%
survival
rate.
Furthermore,
it
verified
that
mechanism
primarily
attributed
to
improved
immunoregulation,
epithelial
repair,
gut
microbiota
remodeling
after
LF‐responsive
effective
inflammatory‐responsive
design
instructive
valuable
develop
more
systems
therapy.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 13, 2025
Structural
nanomedicines
are
engineered
constructs
that
arrange
therapeutic
components
into
well-defined
architectures
to
maximize
efficacy.
Their
multivalent,
multifunctional
design
offers
key
advantages
over
unstructured
formulations,
including
targeted
delivery,
expanded
windows,
and
enhanced
target
engagement.
The
mRNA
COVID-19
vaccines
exemplify
their
transformative
potential.
However,
structural
precision
varies,
more
will
streamline
optimization,
manufacturing,
regulation.
Unlike
small
molecule
drugs,
within
a
batch
not
identical.
Identifying
the
most
effective,
least
toxic
structures
advance
our
understanding
of
structure-function
relationships
mechanisms.
This
work
highlights
nanomedicines─small
molecules,
nucleic
acids,
biologics─to
galvanize
field
drive
innovation
toward
even
safer,
effective
treatments
benefit
patients.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 20, 2025
Gene
therapy
holds
immense
potential
due
to
its
ability
precisely
target
oncogenes,
making
it
a
promising
strategy
for
cancer
treatment.
Advances
in
genetic
science
and
bioinformatics
have
expanded
the
applications
of
gene
delivery
technologies
beyond
detection
diagnosis
therapeutic
interventions.
However,
traditional
faces
significant
challenges,
including
limited
efficacy
rapid
degradation
materials
vivo.
To
address
these
limitations,
multifunctional
nanoparticles
been
engineered
encapsulate
protect
materials,
enhancing
their
stability
effectiveness.
Nanoparticles
are
being
extensively
explored
deliver
various
payloads-including
plasmid
DNA,
messenger
RNA,
small
interfering
RNA-directly
cells.
This
review
highlights
key
modulation
strategies
such
as
RNA
interference,
editing
systems,
chimeric
antigen
receptor
(CAR)
technologies,
alongside
diverse
array
nanoscale
systems
composed
polymers,
lipids,
inorganic
materials.
These
nanoparticle-based
platforms
aim
improve
targeted
transport
material
into
cells,
ultimately
therapies.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 20, 2024
Abstract
Messenger
RNA
(mRNA)‐based
therapies
have
emerged
as
a
revolutionary
strategy
for
treating
various
diseases.
In
autoimmune
diseases
like
rheumatoid
arthritis
(RA),
targeted
mRNA
delivery
provides
potential
intervention
to
modulate
immune
responses.
However,
achieving
specific
and
efficient
in
vivo
modulation
of
regulators,
such
the
inhibitory
Fc
gamma
receptor,
FcγRIIB,
on
B
cells
remains
challenging.
this
study,
lipid
polymer
nanoparticles
(LPNs)
formulated
with
AMB‐POC18
lipidoid
poly(ethylene
glycol)‐
block
‐polylactide
(PEG‐PLA)
are
engineered
deliver
FcγRIIB
(mFcγRIIB)
specifically
splenic
RA
treatment.
Protein
corona
analysis
indicated
that
selective
adsorption
complement
C3
LPNs'
surface
facilitated
their
spleen,
enhancing
transfection
efficiency
following
intravenous
administration.
collagen‐induced
mouse
model,
mFcγRIIB/LPNs
effectively
upregulated
expression
cells,
significantly
reducing
responses
alleviating
symptoms.
Further
mechanistic
studies
elucidated
increased
suppressed
cell
activation
via
FcγRIIB/Lyn/SHP‐1
signaling
pathway.
This
work
underscored
spleen‐targeted
system
therapy,
providing
precise
approach
activity
mitigate
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Dec. 25, 2024
Abstract
Oral
formulation
is
the
ideal
treatment
method
for
inflammatory
bowel
disease
(IBD)
therapy,
but
mucosal
damage
and
diarrhea
symptoms
impede
drug
retention
around
region,
severely
limiting
IBD
therapeutic
efficacy.
To
address
this,
an
oral
astaxanthin
(Ast)
precise
delivery
developed
with
selective
Ast
anchoring
region
by
novel
lactoferrin
(LF)‐responsive
flocculation.
This
also
heightens
apparent
solubility
of
minimized
edible
safety
risks
raw
materials.
For
in
vivo
exhibits
remarkable
outcomes,
including
a
significant
increase
colon
length
100%
survival
rate.
Furthermore,
it
verified
that
mechanism
primarily
attributed
to
improved
immunoregulation,
epithelial
repair,
gut
microbiota
remodeling
after
LF‐responsive
effective
inflammatory‐responsive
design
instructive
valuable
develop
more
systems
therapy.
