Defatted Hickory Meal Hydrolysate's Impact on Memory Impairment Induced by D-Galactose in Mice

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Defatted hickory meal (DHM), a by-product of oil production, is protein source rich in essential amino acids. In this study, the functional properties DHM hydrolysate (DHMH) were assessed using in vitro and vivo assays context to its antioxidant memory-enhancing effects. To induce memory impairment, D-galactose (D-gal) was administered mice at dose 120 mg/kg body weight per day, DHMH orally doses 300, 600, 1000 day for 8 weeks. treatment led improved performance D-gal-induced memory-impaired mice, as observed Morris water maze test. Furthermore, mitigated accumulation amyloid beta 1-42 triggered by D-gal exposure. Notably, high-dose significantly reduced elevation pro-inflammatory markers, including tumor necrosis factor alpha, interleukin 1β, 6. Additionally, prevented decline total superoxide dismutase activity, glutathione peroxidase levels, while reducing malondialdehyde content indicative properties. Moreover, effectively histological alterations neurons within hippocampal CA1 area induced D-gal. Collectively, our findings suggest that may counteract dysfunctions resulting from oxidative stress injury brain, positioning it potential candidate use food.

Language: Английский

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Antioxidant and Neuroprotective Effects of Seed Oils from Trichosanthes kirilowii and T. laceribractea in Caenorhabditis elegans: A Comparative Analysis and Mechanism Study

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 861 - 861

Published: July 18, 2024

Excess reactive oxygen species (ROS) can accelerate amyloid β (Aβ) aggregation and tau protein hyperphosphorylation in neuron cells, which further leads to neurodegenerative diseases such as Alzheimer's disease (AD). Therefore, there is an urgent need find natural safe antioxidants for preventing or treating diseases. The seeds of

Language: Английский

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Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(10), P. 11359 - 11374

Published: Oct. 13, 2024

While Ginsenoside Re has been shown to protect the central nervous system, reports of its effects on memory in model scopolamine-induced impairment are rare. The aim this study was investigate scopolamine (SCOP)-induced damage and mechanism action. Male ICR mice were treated with SCOP (3 mg/kg) for 7 days or without 14 days. As evidenced by behavioral studies (escape latency cross platform position), brain tissue morphology, oxidative stress indicators after treatment, caused significantly ameliorated. Further research indicated that inhibited cell apoptosis regulating PI3K/Akt/Nrf2 pathway, thereby exerting a cognitive improvement effect. This suggests could against SCOP-induced defects possibly through inhibiting apoptosis.

Language: Английский

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An angiotensin-converting enzyme inhibitory peptide LVLPGE exerts an antihypertensive effect and improves endothelial function via eNOS/NO/cGMP pathway

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105488 - 105488

Published: Nov. 17, 2024

Language: Английский

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