Advanced Vibrational Spectroscopy and Bacteriophages Team Up: Dynamic Synergy for Medical and Environmental Applications DOI Open Access
Magdalena Giergiel, Thulya Chakkumpulakkal Puthan Veettil,

Ava Rossetti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8148 - 8148

Published: July 26, 2024

Bacteriophages are emerging as a promising alternative in combating antibiotic-resistant bacteria amidst the escalating global antimicrobial resistance crisis. Recently, there has been notable resurgence of interest phages, prompting extensive research into their therapeutic potential. Beyond conventional microbiology and virology techniques, such genomics proteomics, novel phenotypic chemical characterization methods being explored. Among these, is growing vibrational spectroscopy, especially advanced modalities surface-enhanced Raman spectroscopy (SERS), tip-enhanced (TERS), atomic force microscopy-infrared (AFM-IR), which offer improved sensitivity spatial resolution. This review explores spectrum uses for bacteriophages, including its role diagnostics, biosensing, phage detection, assistance phage-based therapy, advancing basic research.

Language: Английский

Advances in deep learning-based applications for Raman spectroscopy analysis: A mini-review of the progress and challenges DOI
Derrick Ampadu Boateng

Microchemical Journal, Journal Year: 2025, Volume and Issue: 209, P. 112692 - 112692

Published: Jan. 5, 2025

Language: Английский

Citations

3
Advancing clinical diagnostics: the potential of analytical Raman spectroscopy in oncology, dermatology, and diabetes DOI
Rabia’tul A’dawiah, Alex Jie Yap,

Poongkulali Rajarahm

et al.

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 56

Published: April 4, 2025

Language: Английский

Citations

0
Application of Raman Spectroscopy in Drug Discovery DOI
Shweta Chand Thakuri, Komal Rawat, Vijay Kumar Juyal

et al.

Advances in chemical and materials engineering book series, Journal Year: 2025, Volume and Issue: unknown, P. 221 - 254

Published: Feb. 14, 2025

Raman spectroscopy, a powerful vibrational spectroscopy technique, has emerged as pivotal tool in drug discovery and development. Based on the inelastic scattering of monochromatic light, this technique allows for detailed molecular characterization with minimal sample preparation non-destructive analysis. This analytical method provides information about composition, structure, interactions pharmaceutical compounds, facilitating various stages development from initial screening to final quality control. Recent advancements instrumentation, such Surface-Enhanced (SERS) Coherent Anti-Stokes (CARS), have further expanded its applications. Its ability provide insights, coupled technology, positions an indispensable industry, that holds promise accelerating new therapeutics improving efficiency processes.

Language: Английский

Citations

0
Emerging biomedical applications of surface-enhanced Raman spectroscopy integrated with artificial intelligence and microfluidic technologies DOI

Zehra Taş,

Fatih Çiftçi, Kutay İçöz

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 339, P. 126285 - 126285

Published: April 23, 2025

Language: Английский

Citations

0
Prediction of Cardiac Differentiation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Supernatant using Surface-Enhanced Raman Spectroscopy and Machine Learning DOI Creative Commons
Karla Echeverría-Altamar, Carlos Barreto-Gamarra, Maribella Domenech

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117528 - 117528

Published: April 1, 2025

Language: Английский

Citations

0
The application of Raman spectroscopy for the diagnosis and monitoring of lung tumors DOI Creative Commons
Yuyang Miao, Lihong Wu,

Junlian Qiang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 18, 2024

Raman spectroscopy is an optical technique that uses inelastic light scattering in response to vibrating molecules produce chemical fingerprints of tissues, cells, and biofluids. strategies high levels specificity without requiring extensive sample preparation, allowing for the use advanced tools such as microscopes, fiber optics, lasers operate visible near-infrared spectral range, making them increasingly suitable a wide range medical diagnostic applications. Metal nanoparticles nonlinear effects can improve signals, optimized optic probes make real-time,

Language: Английский

Citations

2
Unveiling brain disorders using liquid biopsy and Raman spectroscopy DOI

Jeewan C. Ranasinghe,

Ziyang Wang, Shengxi Huang

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(25), P. 11879 - 11913

Published: Jan. 1, 2024

Brain disorders, including neurodegenerative diseases (NDs) and traumatic brain injury (TBI), present significant challenges in early diagnosis intervention. Conventional imaging modalities, while valuable, lack the molecular specificity necessary for precise disease characterization. Compared to study of conventional tissues, liquid biopsy, which focuses on blood, tear, saliva, cerebrospinal fluid (CSF), also unveils a myriad underlying processes, providing abundant predictive clinical information. In addition, biopsy is minimally- non-invasive, highly repeatable, offering potential continuous monitoring. Raman spectroscopy (RS), with its ability provide rich information cost-effectiveness, holds great transformative advancements detection understanding biochemical changes associated NDs TBI. Recent developments enhancement technologies advanced data analysis methods have enhanced applicability RS probing intricate signatures within biological fluids, new insights into pathology. This review explores growing role as promising emerging tool particularly through biopsy. It discusses current landscape future prospects highlighting non-invasive molecularly specific diagnostic tool.

Language: Английский

Citations

2
Rapid diagnosis of bacterial vaginosis using machine-learning-assisted surface-enhanced Raman spectroscopy of human vaginal fluids DOI Creative Commons

Xin‐Ru Wen,

Jia‐Wei Tang, Jie Chen

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Bacterial vaginosis (BV) is an abnormal gynecological condition caused by the overgrowth of specific bacteria in vagina. This study aims to develop a novel method for BV detection integrating surface-enhanced Raman scattering (SERS) with machine learning (ML) algorithms. Vaginal fluid samples were classified as positive or negative using BVBlue Test and clinical microscopy, followed SERS spectral acquisition construct data set. Preliminary analysis revealed notable disparities characteristic peak features. Multiple ML models constructed optimized, convolutional neural network (CNN) model achieving highest prediction accuracy at 99%. Gradient-weighted class activation mapping (Grad-CAM) was used highlight important regions images prediction. Moreover, CNN blindly tested on spectra vaginal collected from 40 participants unknown infection status, 90.75% compared results combined microscopy. technique simple, cheap, rapid accurately diagnosing bacterial vaginosis, potentially complementing current diagnostic methods laboratories.

Language: Английский

Citations

2
Raman spectroscopy: A promising analytical tool used in human reproductive medicine DOI

Chao Zheng,

Lumei Zhang,

Hefeng Huang

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: 249, P. 116366 - 116366

Published: July 15, 2024

Language: Английский

Citations

1
Advanced Vibrational Spectroscopy and Bacteriophages Team Up: Dynamic Synergy for Medical and Environmental Applications DOI Open Access
Magdalena Giergiel, Thulya Chakkumpulakkal Puthan Veettil,

Ava Rossetti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8148 - 8148

Published: July 26, 2024

Bacteriophages are emerging as a promising alternative in combating antibiotic-resistant bacteria amidst the escalating global antimicrobial resistance crisis. Recently, there has been notable resurgence of interest phages, prompting extensive research into their therapeutic potential. Beyond conventional microbiology and virology techniques, such genomics proteomics, novel phenotypic chemical characterization methods being explored. Among these, is growing vibrational spectroscopy, especially advanced modalities surface-enhanced Raman spectroscopy (SERS), tip-enhanced (TERS), atomic force microscopy-infrared (AFM-IR), which offer improved sensitivity spatial resolution. This review explores spectrum uses for bacteriophages, including its role diagnostics, biosensing, phage detection, assistance phage-based therapy, advancing basic research.

Language: Английский

Citations

1