The Role of Oxidative Stress in the Antifungal Activity of Two Mollusk Fractions on Resistant Fungal Strains

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 985 - 985

Published: Jan. 24, 2025

Fungal infections are a significant global public health challenge because of their widespread occurrence, morbidity, and profound social economic consequences. Antifungal resistance is also an increasing concern, posing substantial risk to health. There growing interest in searching for new antifungal drugs isolated from natural sources. This study aimed evaluate the activity novel mollusk fractions against fungal strains resistant nystatin amphotericin B. In addition, role oxidative stress mechanism damage was determined. The mucus garden snail Cornu aspersum (MCa/1-20) hemolymph fraction marine Rapana venosa (HLRv/3-100) were obtained characterized via 12% sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) mass spectrometric -analyses. results demonstrate that spores biomass both have fungicidal effect Penicillium griseofulvum, Aspergillus niger. Compared control group, release intracellular proteins reducing sugars significantly increased treated groups. data showed levels biomarkers (lipid peroxidation oxidatively damaged proteins) downregulated antioxidant enzyme defense, corresponding activity. To our knowledge, this first evaluating as factor fractions’

Language: Английский

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The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

Triple-negative breast cancer (TNBC) is difficult to treat and has a low five-year survival rate. In South Africa, large percentage of the population still relies on traditional plant-based medicine. To establish utility both methanol water-soluble extracts from leaves Tulbaghia violacea, cytotoxicity assays were carried out IC50 values against TNBC cell line. Cell cycle apoptosis using extracts. identify molecular compounds, present in leaf extracts, NMR spectroscopy was performed. Compounds interest then used computational docking studies with anti-apoptotic protein COX-2. The for water- methanol-soluble determined be 400 820 µg/mL, respectively. extract induced line greater extent than normal RNAseq indicated that there an increase transcription pro-apoptotic genes crude also caused these cells stall S phase. Of 61 compounds identified this extract, five demonstrated high binding affinity Based findings, within show significant potential further investigation as candidates development therapeutics, particularly TNBC.

Language: Английский

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Cuminaldehyde: a potent antifungal agent for managing postharvest blue mold disease in Citrus reticulata Blanco cv. Ponkan

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(5)

Published: April 28, 2025

Language: Английский

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Novel Essential Oil-Based Thiosemicarbazone Compounds as Potential Fungicides in Controlling Postharvest Diseases of Citrus Fruit

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

To develop novel fungicides for controlling postharvest fungal diseases in citrus fruits, 12 essential oil (EO)-based thiosemicarbazones compounds, termed hydrazine-carbothioamide, were prepared according to the condensation method.

Language: Английский

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A combination of cuminaldehyde with citral- / trans-2-hexen-1-al alleviates green mold disease in citrus fruit

Journal of Plant Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Language: Английский

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