Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium : A review

Food Science & Nutrition, Journal Year: 2022, Volume and Issue: 10(6), P. 1789 - 1819

Published: March 4, 2022

Abstract The genus Syzygium comprises 1200–1800 species that belong to the family of Myrtaceae. Moreover, plants are belonged this being used in traditional system medicine Asian countries, especially China, India, and Bangladesh. aim review is describe scientific works provide organized information on available uses, phytochemical constituents, pharmacological activities mostly related was analytically composed from databases, including PubMed, Google Scholar, Science Direct, Web Science, Wiley Online Library, Springer, Research Gate link, published books, conference proceedings. Bioactive compounds such as flavanone derivatives, ellagic acid derivatives other polyphenolics, terpenoids reported several . However, many members need further comprehensive studies regarding constituents mechanism‐based activities.

Language: Английский

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Apoptosis-inducing anti-proliferative and quantitative phytochemical profiling with in silico study of antioxidant-rich Leea aequata L. leaves

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23400 - e23400

Published: Dec. 10, 2023

Natural products have been important parts of traditional medicine since ancient times, with various promising health effects. Leea aequata (L. aequata), a natural product, has widely used for treating several diseases due to its pharmacological activities. Therefore, the present study aimed explore phytochemical profiling and molecular docking antioxidant-rich part L. leaves antiproliferative activity. were extracted methanol, followed by fractionation respective solvents obtain petroleum ether, chloroform, ethyl acetate, aqueous fractions. The antioxidant activity was evaluated spectrophotometric methods. cytotoxic activities detected using MTT colorimetric confocal microscopy methods, respectively. Phytochemical compositions analyzed gas chromatography‒mass spectrometry analysis. Computer aided (molecular SwissADME, AdmetSAR pass prediction) analyses undertaken sort out best-fit phytochemicals in plant responsible anticancer Among fractions, acetate fraction most abundant polyphenol-rich showed highest antioxidant, reducing power, free radical scavenging Compared untreated MCF-7 cells, fraction-treated cells an increase apoptotic characteristics, such as membrane blebbing, chromatin condensation, nuclear fragmentation, causing apoptosis decreased proliferation HeLa cells. Furthermore, chromatography mass data revealed that contained 16 compounds, including methyl esters long-chain fatty acids, which are major chemical constituents. Moreover, hexadecanoic acid, ester; 9-octadecenoic acid (Z)-, 9,12-octadecadienoic ester (Z, Z) phenol, 2,4-bis(1,1-dimethylethyl) known activity, confirmed computer-aided models. A strong correlation observed between polyphenolic contents In conclusion, we explored possibility could be source antioxidants agents high profile.

Language: Английский

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Biofilm inhibition/eradication: exploring strategies and confronting challenges in combatting biofilm

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(5)

Published: April 14, 2024

Language: Английский

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Development of an underutilized part of Syzygium aromaticum based on phytochemical and bioactivity assessment

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144072 - 144072

Published: March 1, 2025

Language: Английский

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Pharmacological and behavioral investigation of putative self-medicative plants in Budongo chimpanzee diets

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0305219 - e0305219

Published: June 20, 2024

Wild chimpanzees consume a variety of plants to meet their dietary needs and maintain wellbeing. While some have obvious value, others are nutritionally poor and/or contain bioactive toxins which make ingestion costly. In cases, these nutrient-poor resources speculated be medicinal, thought help individuals combat illness. this study, we observed two habituated chimpanzee communities living in the Budongo Forest, Uganda, collected 17 botanical samples associated with putative self-medication behaviors (e.g., bark feeding, dead wood eating, pith-stripping) or events when consumer had elevated parasite load, abnormal urinalysis, injury). total, selected plant parts from 13 species (nine trees four herbaceous plants). Three extracts different polarities were produced each sample using n -hexane, ethyl acetate, methanol/water (9/1, v/v ) introduced antibacterial anti-inflammatory vitro models. Extracts evaluated for growth inhibition against panel multidrug-resistant clinical isolates bacteria, including ESKAPE strains cyclooxygenase-2 (COX-2) activity. Pharmacological results suggest that several potent medicinal properties. library screen, 45 out 53 (88%) exhibited ≥40% at concentration 256 μg/mL. Of active extracts, 41 (91%) showed activity ≤256μg/mL subsequent dose-response experiments. The strongest was achieved by n- hexane extract Alstonia boonei Staphylococcus aureus (IC50: 16 μg/mL; MIC: 32 μg/mL) Enterococcus faecium >256 methanol-water Khaya anthotheca resin E . pathogenic Escherichia coli μg/mL). We both highly parasitized individuals. K also targeted indicators infection injuries. All negatively affected COX-2 51 tested (33%) ≥50% 5 Several effects most 0.55 μg/mL), followed fern Christella parasitica 0.81 This consumed an injured individual, feeding behavior documented only once before population. These results, integrated observations eight months behavioral data, provide further evidence presence self-medicative wild diets. study addresses challenge distinguishing preventative food consumption therapeutic integrating pharmacological, observational, health monitoring data—an essential interdisciplinary approach advancing field zoopharmacognosy.

Language: Английский

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Undescribed Triterpenes from the Leaves of Syzygium myrsinifolium with Their α‐Glucosidase and α‐Amylase Inhibition Activity

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(3)

Published: Jan. 27, 2024

Abstract Two undescribed triterpenes, syzyfolium A ( 1 ) and B 2 ), together with twelve known compounds, terminolic acid 3 actinidic 4 piscidinol 5 threo ‐dihydroxydehydrodiconiferyl alcohol 6 lariciresinol‐4‐ O ‐ β ‐D‐glucoside 7 icariol 8 14 ,15 ‐dihydroxyklaineanone 9 garcimangosone D 10 (+)‐catechin 11 myricetin‐3‐ α ‐L‐rhamnopyranoside 12 quercitrin 13 3, 4, 5‐trimethoxyphenyl‐(6′‐ ‐galloyl)‐ ‐D‐glucopyranoside were isolated from the leaves of Syzygium myrsinifolium . Their chemical structures determined by IR, HR‐ESI‐MS, 1D 2D NMR spectra. Compounds inhibited significantly ‐glucosidase IC 50 values 23.99 36.84, respectively, compounds ‐amylase 35.48 43.65 μM, respectively.

Language: Английский

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Chemical composition, antimicrobial and larvicidal activities of essential oils of two Syzygium species from Vietnam

Brazilian Journal of Biology, Journal Year: 2023, Volume and Issue: 84

Published: April 5, 2023

The present study is the first to investigate chemical composition, antimicrobial and larvicidal activities of essential oils from leaves Syzygium attopeuense (Gagnep.) Merr. & L.M.Perry tonkinense collected in Vietnam. were extracted by hydrodistillation analyzed GC GC-MS. indicated presence a high percentage sesquiterpenes both investigated oils. major components S. oil bicyclogermacrene (24.26%), (E)-caryophyllene (11.72%), (E)-β-ocimene (6.75%), whereas was dominated (80.80%). activity evaluated broth microdilution assay determine minimum inhibitory concentration (MIC) median (IC50). Both exhibited remarkable against all tested Gram-positive bacteria yeast than Gram-negative bacteria. Among them, possessed strongest Enterococcus faecalis (MIC = 4.00 μg/mL; IC50 1.69 μg/mL) Candida albicans 16.00 8.67 μg/mL), respectively. Furthermore, using fourth-instar larvae Aedes aegypti. Results test revealed that had an excellent effect A. aegypti with LC50 values 25.55 30.18 μg/mL LC90 33.00 39.01 μg/mL. Our findings demonstrate are potential sources natural antimicrobials can act as inexpensive mosquito agents.

Language: Английский

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Determination of total phenolic and flavonoid contents, antioxidant and antibacterial potential of the bark extracts of Syzygium guineense (Wild.) DC.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 31, 2025

Syzygium guineense (Wild.) DC. is a wild indigenous tree widely used as traditional medicine for various human ailments in Ethiopia. The purpose of this study was to quantify total phenolic (TPC) and flavonoid (TFC) contents determine the antioxidant antibacterial activities solvent extracts bark plant. TPC TFC were determined using Folin-Ciocalteu aluminum chloride methods, respectively. 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, ferric-reducing power, capacity assays evaluate activities. Antibacterial properties disc-diffusion broth dilution assays. ethanol extract found have high (37.80 ± 3.70 mgGAE/g) (19.22 1.44 mgQE/g). Similarly, showed stronger DPPH scavenging activity (EC50 = 5.62 μg/mL). power also strong (163.08±11.67 mgAAE/g 143.72±2.86 mgBHTE/g dried 1 mg/mL, respectively). lowest MIC observed acetone against S. aureus (1.56 mg/mL) K. pneumoniae mg/mL). possesses TFC. In addition, it capacity, asserting content. shown both Gram-positive (S. aureus) Gram-negative bacterial species. Thus, further in-depth investigations may warrant isolation powerful antioxidants potent antimicrobial agents from

Language: Английский

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Chemical profile and antimicrobial potential of essential oils from the leaves and flowers of Syzygium ripicola (Craib) Merr. & L.M.Perry

Journal of Essential Oil Bearing Plants, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 12, 2025

Language: Английский

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Unveiling the Nutraceutical and Nutricosmetic Potential of Syzygium nervosum Flower Buds: A Focus on Phytochemicals and In Vitro Bioactivities

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1762 - 1762

Published: April 15, 2025

The flower buds of Syzygium nervosum are traditional edible and medicinal plant materials for the treatment inflammation stomach disorders. With rising demand natural products in food cosmetics, nutraceutical nutricosmetic potential has been evaluated this work. antioxidant activity ethanol water extracts S. were detected through free radical scavenging (DPPH, ·OH, ABTS) assays, their inhibitory effects on tyrosinase elastase enzymes also evaluated. extract (SNEE) exhibited stronger superior both compared with (SNWE), highlighting its anti-aging skin-whitening applications. Meanwhile, LC-QTOF-MS was employed identification key chemical molecules responsible properties. Moreover, enzyme mechanisms bud further elucidated using inhibition kinetics molecular docking methods. This research underscores promising so as to offer important information developing resource skin feeding bioactive ingredients.

Language: Английский

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