The α-glucosidase inhibitory activity of avicularin and 4-O-methyl gallic acid isolated from Syzygium myrtifolium leaves DOI Creative Commons
Islan Nor,

Komar Ruslan Wirasutisna,

Rika Hartati

et al.

Saudi Pharmaceutical Journal, Journal Year: 2023, Volume and Issue: 31(8), P. 101677 - 101677

Published: June 19, 2023

Diabetes Mellitus is the main cause of death on a global scale. In 2019, there were 463 million people with diabetes, and WHO predicts that by 2030, will be 578 million. As an antidiabetic agent, α-glucosidase inhibitors are one methods employed to reduce prevalence diabetes. traditionally treated Syzygium as primary material, medicine, fruit, ornamental plant, source carpentry. This investigation aimed examine inhibitory effect seven species against enzyme using in vitro assay isolate active substances ascertain their concentrations each sample. solvent, ethanol was used maceration extract substance. Afterward, underwent series fractionation techniques, including liquid-liquid extraction, vacuum liquid chromatography, column preparative Thin Layer Chromatography (TLC) for purification isolation. The compound's structures elucidated TLC, UV-Visible spectrophotometry, nuclear magnetic resonance (NMR) spectroscopy. Based 100 200 µg/mL, myrtifolium exhibited most significant effect, followed other Syzygium. proportion ethyl acetate had strongest activity (IC50 0.40 ± 0.02 µg/mL) contrasted positive control acarbose 55.39 0.67 g/mL) quercitrin 6.47 µg/mL). Avicularin 4-O-methyl gallic acid discovered fraction IC50 values 17.05 0.75 µg/mL 25.19 0.21 respectively. inhibitory, results this study indicate can dietary supplement manage hyperglycemia.

Language: Английский

Roles of Syzygium in Anti-Cholinesterase, Anti-Diabetic, Anti-Inflammatory, and Antioxidant: From Alzheimer’s Perspective DOI Creative Commons
Mira Syahfriena Amir Rawa, Mohd Khairul Nizam Mazlan, Rosliza Ahmad

et al.

Plants, Journal Year: 2022, Volume and Issue: 11(11), P. 1476 - 1476

Published: May 31, 2022

Alzheimer's disease (AD) causes progressive memory loss and cognitive dysfunction. It is triggered by multifaceted burdens such as cholinergic toxicity, insulin resistance, neuroinflammation, oxidative stress. Syzygium plants are ethnomedicinally used in treating inflammation, diabetes, well impairment. They rich antioxidant phenolic compounds, which can be multi-target neuroprotective agents against AD. This review attempts to the pharmacological importance of genus neuroprotection, focusing on anti-cholinesterase, anti-diabetic, anti-inflammatory, properties. Articles published bibliographic databases within recent years relevant neuroprotection were reviewed. About 10 species examined for their anti-cholinesterase capacity. Most studies conducted form extracts rather than compounds. aromaticum (particularly its essential oil eugenol component) represents most studied owing economic significance food therapy. The molecular mechanisms include inhibition AChE correct transmission, suppression pro-inflammatory mediators, stress markers, RIS production, enhancement enzymes, restoration brain ions homeostasis, microglial invasion, modulation ß-cell release, lipid accumulation, glucose uptake, adiponectin secretion via activation signaling pathway. Additional efforts warranted explore less species, including Australian Western species. effectiveness responses markedly established, but further compound isolation, silico, clinical demanded.

Language: Английский

Citations

16
Improvement of phytochemical and quality characteristics of Dracocephalum kotschyi by drying methods DOI Creative Commons
S. Zamani, Davood Bakhshi, Amir Sahraroo

et al.

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(7), P. 4246 - 4262

Published: April 26, 2023

This experiment was conducted to evaluate the effects of different drying methods on parameters and qualitative characteristics

Language: Английский

Citations

9
Anacardic acid derivatives with significant α-glucosidase inhibitory activity from Syzygium samarangense DOI
Yi‐Kao Hu,

Wen Xu,

Li Wang

et al.

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 61, P. 75 - 77

Published: March 30, 2024

Language: Английский

Citations

3
Biological and Medicinal Properties of Natural Chromones and Chromanones DOI Creative Commons
Alexandra Gaspar, E. Manuela Garrido, Fernanda Borges

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: unknown

Published: May 9, 2024

Emerging threats to human health require a concerted effort search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed major advances in field pharmacotherapy, as they offer special characteristics compared conventional synthetic molecules. Interest natural being revitalized, continuous lead structures that can be used models development by pharmaceutical industry. Chromone and chromanones are recognized privileged useful templates design diversified therapeutic molecules potential pharmacological interest. Chromones widely distributed plants fungi, significant biological activities, namely antioxidant, anti-inflammatory, antimicrobial, antiviral, etc., been reported these compounds, suggesting their drug candidates. This review aims update literature published over last 6 years (2018–2023) regarding occurrence activity chromones chromanones, highlighting recent findings perspectives hold future research applications health, cosmetic, food industries.

Language: Английский

Citations

3
Genomic analysis based on chromosome-level genome assembly reveals Myrtaceae evolution and terpene biosynthesis of rose myrtle DOI Creative Commons
Ling Yang, Jingjing Jin, Shanwu Lyu

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: June 10, 2024

Language: Английский

Citations

3
Unveiling the Nutraceutical and Nutricosmetic Potential of Syzygium nervosum Flower Buds: A Focus on Phytochemicals and In Vitro Bioactivities DOI Creative Commons
Yan Liu,

Limei Huang,

Tingting Sun

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1762 - 1762

Published: April 15, 2025

The flower buds of Syzygium nervosum are traditional edible and medicinal plant materials for the treatment inflammation stomach disorders. With rising demand natural products in food cosmetics, nutraceutical nutricosmetic potential has been evaluated this work. antioxidant activity ethanol water extracts S. were detected through free radical scavenging (DPPH, ·OH, ABTS) assays, their inhibitory effects on tyrosinase elastase enzymes also evaluated. extract (SNEE) exhibited stronger superior both compared with (SNWE), highlighting its anti-aging skin-whitening applications. Meanwhile, LC-QTOF-MS was employed identification key chemical molecules responsible properties. Moreover, enzyme mechanisms bud further elucidated using inhibition kinetics molecular docking methods. This research underscores promising so as to offer important information developing resource skin feeding bioactive ingredients.

Language: Английский

Citations

0
Bio-inspired Synthesis of Silver and Zinc Oxide Nanoparticles Using Syzygium salicifolium: Unveiling Versatile In Vitro Biomedical and Photocatalytic Applications DOI
Annie Princy Nadar, Krishnan Sellappan

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(3)

Published: April 25, 2025

Language: Английский

Citations

0
Antibacterial Activities of n-Hexane and Ethyl Acetate Extracts from young leaves of Red Lip (Syzygium myrtifolium (Roxb.) Walp.) DOI
Vilya Syafriana, Yasman Yasman, Wiwik Handayani

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1845 - 1853

Published: April 12, 2025

Syzygium myrtifolium, commonly known as pucuk merah in Indonesia, is not only an ornamental plant but also has the potential a source of antibacterial raw material. Despite several studies reporting its antimicrobial activity against various bacteria and fungi, young leaf extract remains largely unexplored. The present study aimed to investigate using two solvents with different polarities, namely n-hexane ethyl acetate, determine their respective yield values. sequential maceration method was employed bioactive compounds from leaves. results showed that acetate had higher value (17.71%) compared (5.46%) exhibited stronger all five at concentrations 10% 20%. observed variability could be attributed differences metabolite compositions extracts, lacked tannins saponins, which are possess properties. findings this suggest S. myrtifolium leaves may promising agents, particularly pathogenic such Salmonella sp., epidermidis, mutan, pyogenes, P. acnes. However, further research necessary exact mechanism action toxicity these extracts before considering use medicine, cosmetics, or food industries.

Language: Английский

Citations

0
Essential Oils of Five Syzygium Species Growing Wild in Vietnam: Chemical Compositions and Antimicrobial and Mosquito Larvicidal Potentials DOI Creative Commons
Lê Thi Huong, Nguyễn Huy Hùng, Nguyễn Ngọc Linh

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(22), P. 7505 - 7505

Published: Nov. 9, 2023

The essential oils of five Vietnamese Syzygium species (Syzygium levinei, S. acuminatissimum, vestitum, cumini, and buxifolium) were first hydro-distilled analyzed using GC-FID/MS (gas chromatography-flame ionization detection/mass spectrometry). Monoterpene hydrocarbons, sesquiterpene oxygenated sesquiterpenoids the main chemical classes in these oils. All showed good-excellent antimicrobial activities against Gram-positive bacteria Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, yeast Candida albicans. levinei leaf oil, rich bicyclogermacrene (25.3%), (E)-β-elemene (12.2%), (E)-caryophyllene (8.2%), β-selinene (7.4%), as well acuminatissimum fruit oil containing (14.2%), α-pinene (12.1%), caryophyllene oxide (10.9%), (10.8%), α-selinene (8.0%), α-humulene (5.7%), established same MIC value 8 µg/mL E. faecalis B. which much better than positive control streptomycin (MIC 128-256 µg/mL). studied potential to defend mosquitoes since they caused 24 48 h LC50 values less 50 growth Culex quinquefasciatus Aedes aegypti larvae. Especially, buxifolium strongly inhibited Ae. larvae with 6.73 µg/mL, respectively, LC90 13.37 10.83 respectively. These findings imply that might have for use supplemental antibacterial agents or "green" alternatives mosquitoes.

Language: Английский

Citations

8
New Isopropyl Chromone and Flavanone Glucoside Compounds from the Leaves of Syzygium cerasiforme (Blume) Merr. & L.M.Perry and Their Inhibition of Nitric Oxide Production DOI

Bui Hai Ninh,

Dương Thị Dung, Bùi Hữu Tài

et al.

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(3)

Published: March 1, 2023

Abstract A new isopropyl chromone ( 1 ) and a flavanone glucoside 2 together with eleven known compounds 3–13 were isolated from the leaves of Syzygium cerasiforme (Blume) Merr. & L.M.Perry. Their structures elucidated as 5,7‐dihydroxy‐2‐isopropyl‐6,8‐dimethyl‐4 H ‐chromen‐4‐one ), 5,7‐dihydroxyflavanone 7 ‐O‐β‐ D‐(6′′‐ O ‐galloylglucopyranoside) strobopinin 3 demethoxymatteucinol 4 pinocembrin‐7 D‐glucopyranoside 5 (2 S )‐hydroxynaringenin‐7 6 afzelin quercetin 8 kaplanin 9 endoperoxide G3 10 grasshopper 11 vomifoliol 12 litseagermacrane 13 by analysis HR‐ESI‐MS, NMR, CD spectral data. Compounds , inhibited NO production on LPS‐activated RAW264.7 cells IC 50 values 12.28±1.15, 8.52±1.62, 7.68±0.87, 9.67±0.57, 6.69±0.34 μM, respectively, while other ranging 33.38±0.78 to 86.51±2.98 compared that positive control, N G ‐monomethyl‐L‐arginine acetate (L‐NMMA) an value 32.50±1.00 μM.

Language: Английский

Citations

7