Functional roles and novel tools for improving‐oxidative stability of polyunsaturated fatty acids: A comprehensive review

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(6), P. 2471 - 2482

Published: Feb. 28, 2023

Abstract Polyunsaturated fatty acids may be derived from a variety of sources and could incorporated into balanced diet. They protect against wide range illnesses, including cancer osteoarthritis autoimmune problems. The PUFAs, ω‐6, ω‐3 acids, which are found in both the marine terrestrial environments, given special attention. primary goal is to evaluate significant research papers relation human health risks benefits ω‐6 acid dietary resources. This review article highlights types factors affecting stability polyunsaturated methods used for mitigation oxidative stability, future perspectives detail.

Language: Английский

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Therapeutic potential of adiponectin in prediabetes: strategies, challenges, and future directions

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

Adiponectin, an adipose-derived hormone, plays a pivotal role in glucose regulation and lipid metabolism, with decrease circulating adiponectin levels being linked to insulin resistance prediabetes. This review examines the therapeutic potential of managing prediabetes, elucidating on multiple aspects including its influence sensitivity, anti-inflammatory properties. Moreover, paper highlights latest strategies augment levels, such as gene therapy, pharmacological interventions, dietary modifications, lifestyle changes. It also addresses challenges encountered translating preclinical findings into clinical practice, primarily related drug delivery, safety, efficacy. Lastly, proposes future directions, underlining need for large-scale human trials, novel analogs, personalized treatment harness adiponectin’s full preventing transition from prediabetes diabetes.

Language: Английский

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Integration of lipidomics and flavoromics reveals the lipid-flavor transformation mechanism of fish oil from silver carp visceral with different enzymatic hydrolysis

Food Chemistry, Journal Year: 2025, Volume and Issue: 477, P. 143507 - 143507

Published: Feb. 20, 2025

Language: Английский

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Innovative Solutions for Food Analysis: Microextraction Techniques in Lipid Peroxidation Product Detection

Separations, Journal Year: 2023, Volume and Issue: 10(10), P. 531 - 531

Published: Oct. 4, 2023

Lipid peroxidation, the most aggressive reaction in food, results formation of reactive organic compounds that detrimentally impact food sensory qualities and consumers’ health. While controlled lipid peroxidation can enhance flavors appearance certain foods, secondary products lead to deterioration a variety products, such as oils, alcoholic beverages, meat. This publication reviews use modern analytical techniques for detecting quantifying carbonyl compounds, i.e., products. The paper focuses specifically on microextraction-based methods: dispersive liquid-liquid microextraction (DLLME), solid-phase (SPME), gas-diffusion (GDME). These offer efficient sensitive approaches extracting oxidation contribute understanding oxidative various review outlines recent advancements, challenges, limitations these techniques, well emphasizes potential further innovation improvement field analysis.

Language: Английский

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Chemical Characteristics and Thermal Oxidative Stability of Novel Cold-Pressed Oil Blends: GC, LF NMR, and DSC Studies

Foods, Journal Year: 2023, Volume and Issue: 12(14), P. 2660 - 2660

Published: July 10, 2023

Plant oils contain a high content of unsaturated fatty acids. Studies food products have revealed considerable disproportion in the ratio ω6 to ω3. This article presents information on healthful qualities eight new oil blends that beneficial proportion ω3 acids (5:1), as well their degradation during heating at 170 and 200 °C. The acid profile was analyzed by gas chromatography (GC), polar compounds polymers triacylglycerols liquid (LC), water measured Karl Fischer method, oxidative stability differential scanning calorimetry (DSC) low-field nuclear magnetic resonance (LF NMR) methods. results showed heating, fraction increased samples heated both temperatures compared unheated oils. mainly due polymerization forming dimers. In some were heated, particularly those °C, trimers detected, however, even with changes observed, did not go beyond limit. Despite acids, are characterized stability, confirmed thermoanalytical nutritional value developed allow them be used production food, particular ensure an adequate supply

Language: Английский

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Neuroimmunological effects of omega-3 fatty acids on migraine: a review

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: May 6, 2024

Migraine is a highly prevalent disease worldwide, imposing enormous clinical and economic burdens on individuals societies. Current treatments exhibit limited efficacy acceptability, highlighting the need for more effective safety prophylactic approaches, including use of nutraceuticals migraine treatment. involves interactions within central peripheral nervous systems, with significant activation sensitization trigeminovascular system (TVS) in pain generation transmission. The condition influenced by genetic predispositions environmental factors, leading to altered sensory processing. neuroinflammatory response increasingly recognized as key event underpinning pathophysiology migraine, involving complex neuro-glio-vascular interplay. This interplay partially mediated neuropeptides such calcitonin gene receptor peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP) and/or cortical spreading depression (CSD) oxidative stress, mitochondrial dysfunction, nucleotide-binding domain-like family pyrin domain containing-3 (NLRP3) inflammasome formation, activated microglia, reactive astrocytes. Omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) docosahexaenoic (DHA), crucial system, mediate various physiological functions. PUFAs offer cardiovascular, neurological, psychiatric benefits due their potent anti-inflammatory, anti-nociceptive, antioxidant, neuromodulatory properties, which modulate neuroinflammation, neurogenic inflammation, transmission, enhance stability, mood regulation. Moreover, specialized pro-resolving mediators (SPMs), class PUFA-derived lipid mediators, regulate pro-inflammatory resolution pathways, playing anti-inflammatory neurological roles, turn may be beneficial alleviating symptomatology migraine. impact neurobiological pathways have demonstrated lack major adverse events, underscoring multifaceted approach management. Although not all omega-3 trials shown reducing further research needed fully establish understand precise molecular mechanisms underlying effects SPMs progression. review highlights potential modulating brain functions, neuroimmunological effects, suggests promise candidates prophylaxis.

Language: Английский

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Comparative Analysis of Fragrant Oil Extraction from Semen Trichosanthis Using Cold Pressing, Soxhlet Extraction, Subcritical N-Butane Extraction and Supercritical Co2 Extraction Methods

Published: Jan. 1, 2025

The physicochemical properties, chemical compositions, antioxidant activities, and volatile profiles of fragrant Semen Trichosanthis oil (FSTO) extracted via cold pressing (CP), solvent extraction (SE), subcritical n-butane (SBE), supercritical CO2 (SPE) were systematically investigated. Unsaturated fatty acids, primarily trichosanic acid, linoleic oleic accounted for 89.57–92.73% total with SBE showing the highest proportion (92.73%). CP exhibited superior phytosterol content (434.72 mg/100 g) efficacy (DPPH IC50: 11.857 mg/mL; ABTS 14.382 mg/mL). achieved phenolic (62.08 μg GAE/g) oxidative stability (1.24 h). Rheological analysis revealed Newtonian behavior, SPE oils demonstrating lowest activation energy. GC-IMS identified 108 VOCs, presenting more complex profiles. These findings highlight critical role methods in determining quality, aroma, bioactive properties seed oils.

Language: Английский

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Replacing milk fat with pumpkin seed oil in yogurt

Italian Journal of Food Science, Journal Year: 2025, Volume and Issue: 37(1), P. 384 - 395

Published: Jan. 7, 2025

This study explored the potential of pumpkin seed oil (PSO) in enhancing health benefits yogurt by partially replacing milk fat. Yogurt was produced with varying amounts PSO—0.0, 1, 2, 3, and 4%—to replace 2% PSO showed higher levels unsaturated fatty acids, conjugated linoleic acid, total phenols, antioxidants, while also showing reduced free acids peroxide values. Although texture remained unchanged, we observed significant differences color, flavor, overall acceptability between treated control group. As content increased, decreased.

Language: Английский

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Antimicrobial and Antioxidant Properties of Sambucus nigra L. (Elderflower) Oil: A Molecular Docking and Biochemical Study

Agronomy, Journal Year: 2025, Volume and Issue: 15(2), P. 310 - 310

Published: Jan. 26, 2025

The present study investigates the antimicrobial and antioxidant potential of an essential oil extracted from Sambucus nigra L. flowers. Using hydrodistillation, volatile compounds were profiled through GC–MS analysis for fatty acid profile compounds. demonstrated a balanced composition saturated acids, monounsaturated polyunsaturated with oleic, palmitic, linolenic acids as key contributors. revealed dominance nonanal, cis-rose oxide, trans-rose 2-Pentadecanone, 6,10,14-trimethyl-. Antioxidant activity was assessed using 1,1-Diphenyl-2-Picrylhydrazyl radical scavenging assay, showing significant inhibition, IC50 value 2.52 mg/mL. Antimicrobial efficacy determined against Gram-positive, Gram-negative, fungal strains, highlighting moderate inhibitory Streptococcus pyogenes, Staphylococcus aureus, Candida albicans. S. exhibited more especially C. albicans, compared to bacterial which might be attributed differences in permeability cell wall between fungi bacteria. Among bacteria, E. coli most susceptible, while P. aeruginosa showed resistance, agreement its known stronger membrane structure efflux mechanisms. Molecular docking conducted evaluate effects on microbial proteins corroborate observed vitro outcome. results indicated that 2-pentadecanone, 6,10,14-trimethyl- displayed interesting hydrophilic hydrophobic binding interactions putative proteins. These findings elucidate bioactive role oils, suggesting their therapeutic agents managing oxidative stress infections.

Language: Английский

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Functional foods for bone and joint health: building a solid foundation

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 233 - 256

Published: Jan. 1, 2025

Language: Английский

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