Controlled Aerobic Oxidative Dimerization of Hydroxystilbenoids by Chromium Catalysis

Organic Letters, Journal Year: 2024, Volume and Issue: 26(20), P. 4178 - 4182

Published: May 10, 2024

Aerobic oxidative dimerization of hydroxystilbenoids is described. A Cr–salen complex catalyzed the in 1,1,1,3,3,3-hexafluoroisopropanol to form compounds comprising a natural product-like scaffold (quadrangularin) or its precursor depending on aromatic substituents. The addition catalytic amount scandium triflate [Sc(OTf)3] reaction system altered outcome give different compound, pallidol-type dimer.

Language: Английский

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Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases

Stresses, Journal Year: 2024, Volume and Issue: 4(4), P. 827 - 849

Published: Dec. 2, 2024

Neurodegenerative diseases are devastating conditions with a rising incidence and prevalence due to the aging of population for which we currently do not have efficient therapies. Despite compelling evidence provided by basic research on involvement oxidative stress in their pathogenesis, most trials antioxidants failed. The reasons may relate low bioavailability used compounds or starting therapy late, when pathogenic cascades already induced irreversible damage. current review discusses sources central nervous system, reactive oxygen species pathogenesis Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, importance further improved delivery methods as well search biomarkers that could help early diagnosis hope finding more therapies these diseases.

Language: Английский

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Overexpression of the Mas1 gene mitigated LPS-induced inflammatory injury in mammary epithelial cells by inhibiting the NF-κB/MAPKs signaling pathways

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: July 12, 2024

Breast infection is the primary etiology of mastitis in dairy cows, leading to a reduction quality products and resulting substantial economic losses for animal husbandry. Although antibiotic treatment can eliminate pathogenic microorganisms that induce mastitis, it cannot repair inflammatory damage mammary epithelial cells blood milk barrier. Mas1 G protein-coupled receptor, its role lipopolysaccharide (LPS) -induced injury has not been studied. LPS EpH4 EV led significant downregulation transcript levels, which attracted our great interest, suggesting may be an important target mastitis. Therefore, this study intends verify by gene overexpression technology silencing technology. The findings demonstrated effectively reversed activation nuclear factor-κB/mitogen-activated protein kinase (NF-κB/MAPK) signaling pathways induced LPS, while also suppressing upregulation pro-inflammatory mediators. Furthermore, zonula occludens 1 (ZO-1), Occludin, Claudin-3 caused could promote blood-milk However, using siRNA resulted contrasting effect. These results indicated alleviated LPS.

Language: Английский

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Sprayable Nanocomposites Hydrogel for Wound Healing and Skin Regeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Wound management remains a critical challenge worldwide and imposes huge financial burden on every nation. Hydrogels are promising for biomedical applications because of their extracellular matrix (ECM) like structure, good biocompatibility multifunctional bioactivity. However, the poor mechanical properties inconvenient operation traditional hydrogels make it difficult to meet complex multifaceted needs clinical practice. In recent years, nanocomposites hydrogel with especially sprayable feature have shown enhanced facile operation, which enable value. A unique powerful nanocomposite (NCH) platform is developed by combining many advantages nanomaterials hydrogels, can achieve efficient trauma repair. This work reviews important advances preparation, functions NCH platforms. The challenges future trends in field aim providing researchers clarity past, present, emerging also proposed detail.

Language: Английский

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