The potential mitigating activity of Cassia absus seed extract on carbon tetrachloride-induced liver injury DOI Creative Commons

Ifrah Hussain,

Fiaz-ud-Din Ahmad, Ammara Asif

et al.

Journal of Herbmed Pharmacology, Journal Year: 2024, Volume and Issue: 14(1), P. 90 - 96

Published: Dec. 25, 2024

Introduction: Carbon tetrachloride (CCl4 ) is a chemical that can induce injury in the liver. The aim was to evaluate any potential hepatoprotective of seed extract from Cassia absus against CCl4 -induced liver toxicity Wister rats. Methods: To this end, an aqueous-methanolic C. seeds prepared by maceration. In vitro testing included phytochemical screening and high-performance liquid chromatography (HPLC) analysis phenolic compound constituents. An vivo study involved single exposure either alone or combination with agent, silymarin, administered orally over 28 days. Serum biochemical markers cell were measured post-mortem tissues examined histopathologically using eosin-hematoxylin staining microscopy. Results: HPLC specifically identified presence gallic acid, vanillic catechin, p-coumaric acid. addition, no changes observed animal body weights during treatment protocol. However, both plant silymarin reversed induced elevated serum concentrations aspartate aminotransferase (AST), total bilirubin, alkaline phosphatase (ALP), alanine transaminase (P<0.05) addition histopathological injury. also had dose-related hepatotoxic mitigating effect, findings analogous those standard comparator, silymarin. Conclusion: These outcomes substantiate protective effect hepatotoxicity model.

Language: Английский

Silymarin as a Therapeutic Agent for Hepatocellular Carcinoma: A Multi-Approach Computational Study DOI Creative Commons
Ouided Benslama, Sabrina Lekmine, Hamza Moussa

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 53 - 53

Published: Jan. 15, 2025

Hepatocellular carcinoma (HCC) is a prevalent and lethal form of liver cancer with limited treatment options. Silymarin, flavonoid complex derived from milk thistle, has shown promise in disease due to its antioxidant, anti-inflammatory, anticancer properties. This study aims explore the therapeutic potential silymarin HCC through comprehensive silico approach. employed network pharmacology approach identify key molecular targets HCC. The Genecards Metascape databases were used for target identification functional annotation. Molecular docking analysis was conducted on primary components against VEGFA SRC proteins, which are critical progression. MD simulations followed assess stability interactions docked complexes. Network identified several pathways implicated results revealed strong binding affinities SRC, Silybin A Isosilybin B showing highest affinities. confirmed these interactions, indicating inhibitory effects provides evaluation silymarin's findings suggest that silymarin, particularly B, may effectively offering promising avenue treatment. Further experimental validation warranted confirm facilitate development silymarin-based therapeutics

Language: Английский

Citations

2
Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review DOI Open Access

Devshree Dhande,

Archana Dhok, Ashish Anjankar

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 17, 2024

Chronic liver diseases (CLDs) such as chronic hepatitis, cirrhosis, and non-alcoholic fatty disease (NAFLD) present significant global health challenges due to their high morbidity mortality rates. Silymarin, a flavonoid complex derived from the seeds of milk thistle plant (Silybum marianum), has been extensively studied for its hepatoprotective properties. This review aims evaluate role silymarin an antioxidant therapy in managing CLDs. We explore efficacy, safety, mechanisms action through comprehensive analysis clinical trials scientific studies. Silymarin offers protective effects on shows promise improving function histological outcomes various conditions. Despite promising results, further research is needed fully elucidate optimal dosing regimens, long-term potential drug interactions silymarin. underscores therapeutic CLDs provides foundation future studies aimed at enhancing application.

Language: Английский

Citations

4
Silybin Cocrystals with Improved Solubility and Bioavailability DOI Creative Commons
Bingqing Zhu, Zhenfeng Ding,

Xiaoyi Rong

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 90 - 90

Published: Jan. 13, 2025

Backgroud/Objectives: Silymarin, an extract from milk thistle, is widely recognized for its therapeutic potential in treating liver disorders. However, clinical utility limited by the poor solubility and low bioavailability of key active ingredient, Silybin. In this study, we sought to address issue through development a novel cocrystal Silyin. Methods: Silybin-L-proline was synthesized physicochemical properties were characterized PXRD, TGA, DSC, FTIR. Dissolution tests conducted various pH solutions, impact precipitation inhibitors evaluated. Furthermore, pharmacokinetic study rats performed assess bioavailability. Results: The dissolution studies demonstrated that has significant improvement performance, particularly acidic environments. use inhibitors, such as PVP, prolonged supersaturation period adequate absorption. Pharmacokinetic revealed exhibited 16-fold increase compared raw Silybin extract, outperforming commercial Silybin–phosphatidylcholine complex. Conclusions: Silybin–L-proline significantly enhances bioavailability, indicating improve efficacy applications.

Language: Английский

Citations

0
Investigating the Protective Effects of Luteolin and Gallic Acid from Luffa acutangula L. (Roxb.) amara (Roxb.) C. B. Clarke. Fruit Pericarp Against Alcohol-Induced Liver Toxicity: Extraction, Bioactivity-Guided Fractionation, Molecular Docking, and Dynamics Studies DOI
Mohan Kalaskar, S. Prabhu, Muniappan Ayyanar

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119377 - 119377

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effects of Silibinin on Delaying Aging in Drosophila melanogaster DOI Creative Commons
Kai Zhu,

Hang Ni,

Eqra Hafeez

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 147 - 147

Published: Jan. 27, 2025

Aging is an inevitable physiological process, but delaying aging has always been enduring human pursuit. Silibinin (SIL), derived from the seeds of milk thistle plant, exhibits a broad spectrum pharmacological properties, including anti-tumor effects, liver protection, inhibition apoptosis, and alleviation inflammation. However, whether it anti-aging effects remains unclear. The SIL dietary supplement to Drosophila melanogaster prolonged lifespan, improved climbing ability, ameliorated age-associated intestinal barrier disruption, enhanced resistance oxidative stress, increased enzyme activities superoxide dismutase (SOD) catalase (CAT). Furthermore, RNA-seq results showed that addition significantly upregulated 74 genes downregulated 50 compared with control. KEGG (Kyoto Encyclopedia genomes) analysis demonstrated these differentially expressed were primarily involved in Toll signaling pathway endoplasmic reticulum proteins processing, six among which, IM2, IM3, Drsl3, CG7556, GCS1, TRAM, particularly regulation by supplementation. indicate enhancing antioxidant capacity regulating aging-related pathways. Therefore, shows potential application regimens.

Language: Английский

Citations

0
Magnolin ameliorates acetaminophen-induced liver injury in mice via modulating the MAPK pathway and lipid metabolism DOI
Ting Yao, Youhe Wu,

Liyun Fu

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117264 - 117264

Published: Feb. 1, 2025

Language: Английский

Citations

0
Especies vegetales para las alteraciones hepatobiliares: cardo mariano DOI
Marta Sánchez, M. Pilar Gómez‐Serranillos

Panorama actual del medicamento, Journal Year: 2025, Volume and Issue: unknown, P. 139 - 145

Published: Feb. 25, 2025

Silybum marianum, perteneciente a la familia Asteraceae y comúnmente conocido como “cardo mariano”, es una especie vegetal utilizada por sus propiedades terapéuticas desde hace más de 2000 años cuyos frutos contienen mezcla flavonolignanos conocidos colectivamente silimarina, siendo silibina (también llamada silibinina) el componente principal. Este artículo revisión se centra en química planta destaca potencial farmacológico marianum. Tanto extracto estandarizado silimarina han mostrado antiinflamatorias, antioxidantes proapoptóticas, que afectan varias vías mecanismos celulares. Estas acciones respaldan beneficios demostrados principalmente protector hepático, además neuroprotección, cardioprotección alteraciones metabólicas su agente anticancerígeno antidiabético, respaldado estudios extensos datos experimentales. Ha demostrado ser particularmente eficaz para proteger función hepática, reducir mortalidad debido enfermedad hepática preservar salud del hígado al mitigar estrés oxidativo citotoxicidad. Todo ello, junto con prácticamente nula toxicidad, suponga opción terapéutica frente afecciones hepáticas, incluida cirrosis daño hepático inducido alcohol, drogas graso.

Citations

0
Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats DOI
Roland Eghoghosoa Akhigbe, Adebayo Oluwafemi Adekunle, Moyosore Salihu Ajao

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151668 - 151668

Published: March 1, 2025

Language: Английский

Citations

0
Protective potential of Carduus marianus extract against p-dimethylaminoazobenzene (pDAB) induced hepatocarcinogenesis in mice through apoptosis induction and antioxidant pathway DOI Creative Commons
Saili Paul, Anisur Rahman Khuda‐Bukhsh

Journal of Holistic Integrative Pharmacy, Journal Year: 2025, Volume and Issue: 6(1), P. 64 - 73

Published: March 1, 2025

Language: Английский

Citations

0
Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury DOI Creative Commons

Kasra Shahsavari,

Shireen Shams Ardekani,

Mohammad Reza Shams Ardekani

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 12, 2025

It is widely believed that Silybum marianum (Silymarin) alleviates liver injury arising from various etiologies with different degrees of damage through its anti-inflammatory and antioxidant activities. This meta-analysis investigated the effects silymarin administration on serum levels enzymes including AST, ALT ALP. From inception to November, 2023, a comprehensive literature search was conducted. Inclusion criteria for this study were randomized trials provided sufficient data each group at beginning end follow-up period. Ultimately, 55 studies total 3545 patients included. Comprehensive Meta-Analysis (CMA) V4 software used meta-analysis. Begg's funnel plot symmetry status, rank correlation, Egger's weighted regression tests examine potential publication bias. According findings showed significant reduction in AST (SMD [95% CI]: - 0.670 [- 0.931, 0.408], p-value = 0.000), 0.912 1.177, 0.646], 0.000) levels. While it had no statistically effect ALP level 0.236 1.929, 1.458], 0.159). Meta-regression analysis there association between dose, age, BMI, treatment duration hepatoprotective silymarin. In subgroup analysis, greater observed under 50 years old. The also decrease BMI less than 30, while ≥ 30. Silymarin dose 400 mg ≤ 2 months decreasing compared high doses longer duration. significantly decreased NAFLD viral hepatitis, drugs induced alcohol-related disease. Modifying recommended causes damage.

Language: Английский

Citations

0