Journal of Herbmed Pharmacology,
Journal Year:
2024,
Volume and Issue:
14(1), P. 90 - 96
Published: Dec. 25, 2024
Introduction:
Carbon
tetrachloride
(CCl4
)
is
a
chemical
that
can
induce
injury
in
the
liver.
The
aim
was
to
evaluate
any
potential
hepatoprotective
of
seed
extract
from
Cassia
absus
against
CCl4
-induced
liver
toxicity
Wister
rats.
Methods:
To
this
end,
an
aqueous-methanolic
C.
seeds
prepared
by
maceration.
In
vitro
testing
included
phytochemical
screening
and
high-performance
liquid
chromatography
(HPLC)
analysis
phenolic
compound
constituents.
An
vivo
study
involved
single
exposure
either
alone
or
combination
with
agent,
silymarin,
administered
orally
over
28
days.
Serum
biochemical
markers
cell
were
measured
post-mortem
tissues
examined
histopathologically
using
eosin-hematoxylin
staining
microscopy.
Results:
HPLC
specifically
identified
presence
gallic
acid,
vanillic
catechin,
p-coumaric
acid.
addition,
no
changes
observed
animal
body
weights
during
treatment
protocol.
However,
both
plant
silymarin
reversed
induced
elevated
serum
concentrations
aspartate
aminotransferase
(AST),
total
bilirubin,
alkaline
phosphatase
(ALP),
alanine
transaminase
(P<0.05)
addition
histopathological
injury.
also
had
dose-related
hepatotoxic
mitigating
effect,
findings
analogous
those
standard
comparator,
silymarin.
Conclusion:
These
outcomes
substantiate
protective
effect
hepatotoxicity
model.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(19), P. 4576 - 4576
Published: Sept. 26, 2024
Oxidative
stress
is
a
key
factor
in
the
development
of
chronic
diseases
such
as
type
2
diabetes,
cardiovascular
diseases,
and
liver
disorders.
Antioxidant
therapies
that
target
oxidative
damage
show
significant
promise
preventing
treating
these
conditions.
Berberine,
an
alkaloid
derived
from
various
plants
Berberidaceae
family,
enhances
cellular
defenses
against
through
several
mechanisms.
It
activates
AMP-activated
protein
kinase
(AMPK)
pathway,
which
reduces
mitochondrial
reactive
oxygen
species
(ROS)
production
improves
energy
metabolism.
Furthermore,
it
boosts
activity
antioxidant
enzymes
like
superoxide
dismutase
(SOD),
catalase
(CAT),
glutathione
peroxidase
(GPx),
thus
protecting
cells
damage.
These
actions
make
berberine
effective
managing
conditions,
neurodegenerative
Silymarin,
flavonolignan
complex
Silybum
marianum,
particularly
for
protection.
nuclear
erythroid
2-related
(Nrf2)
enhancing
enzyme
expression
stabilizing
membranes.
Additionally,
silymarin
formation
ROS
by
chelating
metal
ions,
also
diminishes
inflammation.
This
makes
beneficial
conditions
non-alcoholic
fatty
disease
(NAFLD)
alcohol-related
review
aims
to
highlight
distinct
mechanisms
exert
their
effects.
Silymarin,
derived
from
Silybum
marianum
(milk
thistle)
seeds,
is
known
for
its
anti-oxidative
properties.
The
study
examines
how
various
concentrations
of
silymarin
(0,
25,
50,
and
100
mg/L)
affect
activity,
phenolic
content,
pH,
viscosity,
sensory
qualities,
Lactobacillus
delbrueckii
(L.
delbrueckii)
viability
in
yogurt
stored
7,
14,
21
days
at
4
°C,
aiming
to
understand
impact
on
quality
health-promoting
Antioxidant
activity
L.
fortified
were
increased
(58.26
mg
GAE/g
17.45%)
with
increasing
the
concentration
while
decreasing
scores.
A
T3
(100
silymarin/L)
exhibited
viscosity
7.06
±
0.79
6.27
0.13
Pa·s
Days
1–21,
T0
(control)
had
higher
11.36
0.63
9.48
0.16
Pa·s.
Microbial
counts
decreased
4.7–7.14
7.6–12.3
log
CFU/g
by
predominant
Streptococcus
thermophilus
(S.
thermophiles)
bulgaricus
bulgaricus),
absence
coliforms,
minimal
mold
yeast
growth.
Initially,
T1
was
preferred
due
superior
flavor,
texture,
overall
acceptability
Controlled
addition
improves
yogurt's
antioxidant
bacterial
without
compromising
attributes,
making
it
a
promising
functional
food.
BMC Complementary Medicine and Therapies,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Sept. 4, 2024
Breast
cancer
is
one
of
the
most
common
diseases
globally
that
may
have
side
effects
on
liver
and
renal
function.
Pharmacological
treatments
to
reduce
adverse
are
still
limited.
It
has
been
proposed
silymarin
possess
hepatoprotective
anti-inflammatory
properties.
The
present
trial
aims
assess
hepatorenal
protective
efficacy
supplementation
in
patients
receiving
chemotherapy
an
outpatient
setting.
Veterinarska stanica,
Journal Year:
2024,
Volume and Issue:
56(2), P. 257 - 264
Published: Aug. 16, 2024
Silymarin
is
a
mixture
of
flavonolignan
fractions
from
the
medicinal
plant
milk
thistle,
which
primarily
used
as
hepatoprotector
in
humans
and
animals,
acts
an
antioxidant,
anti-inflammatory,
antifibrotic,
antiapoptotic
agent.
As
dietary
supplement,
it
increasingly
to
treat
various
liver
diseases,
some
intoxications,
prevent
side
effects
chemotherapy
protect
kidneys
dogs,
birds,
poultry,
rabbits,
cats,
horses
other
animals.
The
use
silymarin
dairy
cows
showed
improved
biochemical
profile
cows,
reduced
occurrence
ketosis
increased
production.
In
pigs,
nutrient
digestibility,
total
average
daily
feed
intake,
weight
gain
improved,
while
sport
horses,
supplementation
accelerated
return
cortisol
levels
pre-exercise
levels.
Lipidosis
or
fatty
disease
common
disorder
among
captive
parrots.
After
long-term
administration
100–150
mg/kg
food
every
8–12
hours,
health
condition
significantly
according
testimonies
parrot
owners
veterinarians.
intensive
poultry
production
systems,
broilers
hepatotonic,
improve
carcass
characteristics,
boost
immune
system
intestinal
health,
growth
promoter,
laying
hens
egg
quality.
addition,
mitigated
negative
mycotoxins
broilers,chickens
Japanese
quails.
Although
numerous
studies
are
known
about
effect
thistle
silymarin,
their
on
animals
not
yet
widespread.
Hop and Medicinal Plants,
Journal Year:
2024,
Volume and Issue:
32(1-2), P. 225 - 235
Published: Dec. 26, 2024
Silybum
marianum
(L.)
Gaertn.
is
a
major
source
of
active
principles,
but
also
plant
that
perfectly
meets
the
needs
sustainable
agriculture.
The
present
research
analyses
efficiency
organic
fertilization
for
increase
principles
in
fruits
milk
thistle
cultivated
area
Măciuca,
southern
Vâlcea
County,
Romania.
aim
this
work
was
spectrophotometric
determination
total
polyphenols
content
(TPC)
five
different
genotypes
(Prahova,
a1;
Secuieni,
a2;
Iași,
a3;
Dacia
Plant,
a4;
Brașov,
a5)
both
unfertilized,
and
treated
with
fertilizers.
Significant
quantitative
differences
were
identified
between
populations
marianum,
"Dacia
Plant"
fertilized
"Prahova"
unfertilized
presenting
highest
TPC
(18.87
mg
GAE/g,
18.15
respectively).
Fertilization
did
not
necessarily
have
an
impact
on
accumulation
fruits,
climatic
soil
conditions,
as
well
genetic
background
being
able
to
influence
quality
fruits.
Journal of Herbmed Pharmacology,
Journal Year:
2024,
Volume and Issue:
14(1), P. 90 - 96
Published: Dec. 25, 2024
Introduction:
Carbon
tetrachloride
(CCl4
)
is
a
chemical
that
can
induce
injury
in
the
liver.
The
aim
was
to
evaluate
any
potential
hepatoprotective
of
seed
extract
from
Cassia
absus
against
CCl4
-induced
liver
toxicity
Wister
rats.
Methods:
To
this
end,
an
aqueous-methanolic
C.
seeds
prepared
by
maceration.
In
vitro
testing
included
phytochemical
screening
and
high-performance
liquid
chromatography
(HPLC)
analysis
phenolic
compound
constituents.
An
vivo
study
involved
single
exposure
either
alone
or
combination
with
agent,
silymarin,
administered
orally
over
28
days.
Serum
biochemical
markers
cell
were
measured
post-mortem
tissues
examined
histopathologically
using
eosin-hematoxylin
staining
microscopy.
Results:
HPLC
specifically
identified
presence
gallic
acid,
vanillic
catechin,
p-coumaric
acid.
addition,
no
changes
observed
animal
body
weights
during
treatment
protocol.
However,
both
plant
silymarin
reversed
induced
elevated
serum
concentrations
aspartate
aminotransferase
(AST),
total
bilirubin,
alkaline
phosphatase
(ALP),
alanine
transaminase
(P<0.05)
addition
histopathological
injury.
also
had
dose-related
hepatotoxic
mitigating
effect,
findings
analogous
those
standard
comparator,
silymarin.
Conclusion:
These
outcomes
substantiate
protective
effect
hepatotoxicity
model.
