Molecular mechanisms of action of DIM and its clinical application DOI
Е. А. Никитина, S. V. Orlova, Т. Т. Батышева

et al.

Medical alphabet, Journal Year: 2024, Volume and Issue: 19, P. 9 - 15

Published: Oct. 30, 2024

Optimal nutrition requires complete provision of the human needs not only for energy, macro- and micronutrients, but also minor biologically active substances. Some most promising chemoprotectors are glucosinolates their derivatives, such as 3,3’-diindolylmethane (DIM). DIM has ability to inhibit development progression neoplasia by regulating multiple intracellular signaling pathways. Currently, clinical efficacy is being studied in breast prostate cancer, possibility using DIM’s antioxidant anti-inflammatory properties neurodegenerative, metabolic immune diseases investigated.

Language: Английский

Consumption of a Coffee Rich in Phenolic Compounds May Improve the Body Composition of People with Overweight or Obesity: Preliminary Insights from a Randomized, Controlled and Blind Crossover Study DOI Open Access
Álvaro Fernández-Cardero, José Luis Sierra-Cinos, Laura Bravo

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2848 - 2848

Published: Aug. 26, 2024

This study analyzes the effects on body composition and variables related to metabolic syndrome of two coffees with different degree roasting phenolic content. Sixty participants mass index between 25 35 kg/m2 a median age 51.0 years (Interquartile range 46.3–56) were recruited. The was controlled, randomized, single-blind crossover trial consisting in drinking three cups/day roasted coffee (RC) or lightly (LRC) during 12 weeks 2-week wash-out stages before each intervention. LRC contained ≈400 mg hydroxycinnamic acids ≈130 caffeine per 200 mL/cup while RC ≈150 ≈70 mL/cup. Along study, six visits, blood pressure, by bioimpedance, anthropometric measurements, biochemistry analyzed. mean differences p values calculated using linear mixed model (JASP.v.0.18.0.3). A total 38 completed study. After consumption both coffees, fat percentage (LRC: −1.4%, < 0.001; RC: −1.0%, = 0.005) reduced, whereas muscle slightly increased 0.8%, 0.7%, 0.002). decrease greater compared (−0.8%; 0.029). There no significant changes weight. In conclusion, superior at inducing composition.

Language: Английский

Citations

4
The Role of Xenobiotic Caffeine on Cardiovascular Health: Promises and Challenges DOI Creative Commons
Roberto Campagna, Arianna Vignini

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 51 - 51

Published: March 31, 2025

Cardiovascular diseases (CVDs) represent a leading cause of premature mortality and disability worldwide, with their incidence expected to rise, potentially reaching 24 million deaths per year by 2030. These multifactorial diseases, including hypertension, coronary artery disease, arrhythmia, heart failure, are often linked metabolic disturbances such as diabetes, oxidative stress, endothelial dysfunction, inflammation. Natural compounds, caffeine, have been explored for potential therapeutic effects on CVDs. Caffeine, found in coffee, tea, cocoa, various energy drinks, is widely consumed psychoactive compound noted analgesic anti-inflammatory properties. Despite its long history use, caffeine’s impact cardiovascular health remains controversial, both beneficial harmful reported. This review examines the current literature caffeine (CVDs), an emphasis preclinical clinical studies, pharmacokinetic properties, molecular mechanisms it modulates. There evidence that moderate intake can be some CVDs, while other dyslipidemia, collected so far suggests could detrimental since increases total cholesterol levels. But variability dosage, patterns, individual factors (such genetics diet) complicates reliability results. Additionally, challenges related dose standardization absence consistent trial designs hinder full utilization CVD treatment. Nonetheless, appears safe individuals without significant conditions. Future research should aim well-designed studies precise patient cohorts standardized methodologies better assess role management.

Language: Английский

Citations

0
HABITUAL COFFEE CONSUMPTION AND RISK OF CARDIOVASCULAR AND ALL-CAUSE MORTALITY IN THE PAMELA HYPERTENSIVE POPULATION. DOI
Fosca Quarti‐Trevano, Rita Facchetti, Cesare Cuspidi

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 103776 - 103776

Published: Oct. 1, 2024

Language: Английский

Citations

1
Impact of Coffee Intake on Human Aging: Epidemiology and Cellular Mechanisms DOI Creative Commons
Cátia R. Lopes, Rodrigo A. Cunha

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102581 - 102581

Published: Nov. 16, 2024

Language: Английский

Citations

1
Molecular mechanisms of action of DIM and its clinical application DOI
Е. А. Никитина, S. V. Orlova, Т. Т. Батышева

et al.

Medical alphabet, Journal Year: 2024, Volume and Issue: 19, P. 9 - 15

Published: Oct. 30, 2024

Optimal nutrition requires complete provision of the human needs not only for energy, macro- and micronutrients, but also minor biologically active substances. Some most promising chemoprotectors are glucosinolates their derivatives, such as 3,3’-diindolylmethane (DIM). DIM has ability to inhibit development progression neoplasia by regulating multiple intracellular signaling pathways. Currently, clinical efficacy is being studied in breast prostate cancer, possibility using DIM’s antioxidant anti-inflammatory properties neurodegenerative, metabolic immune diseases investigated.

Language: Английский

Citations

0