A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties DOI Creative Commons

Nadia Zargarani,

Mahsa Kavousi, Elaheh Aliasgari

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 12, 2025

Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cell types. We synthesized optimized niosome NPs (NPs) with high solubility capacity for solanine loading. In this study, cytotoxic, cycle inhibitory apoptotic effects solanine-loaded (SN-NPs) on MCF-7 were investigated. Thin-layer hydration was used generate SN-NPs their features validated. The pH-dependent release pattern also examined. Synthesized evaluated cytotoxicity against MCF-10 lines using MTT. Primary secondary apoptosis, necrosis, arrest measured flowcytometry. Lastly, q-PCR assess genes. had an average size between 50 70 nm, a polydispersity index (PDI) 0.452. effectively incorporated into noisome NPs, as encapsulation efficiency 82.3%±0.24%. After quick burst at pH 7 5, released slowly sustainedly. IC50 niosomes cells decreased from 40 mg/100 mL 10 (48 h) 5 (72 h). 72 h, caused late 30% necrosis 5.06% (p < 0.01). 81% G0/G1 phase, only 12% progressing G2/M Solanine-loaded significantly increased Bax CDH-1 gene malignant compared free 0.0001). Bcl-2 MMP2 group 0.001). Solanine-containing showed significant anticancer breast cells, which supported regulation expression. regulated precise delivery show considerable translational potential. This improved nanocarrier technology may increase bioavailability efficacy solanine, potentially leading clinical outcomes therapy.

Language: Английский

A case of non-alcoholic steatohepatitis solved by unani formulations (Qurs-e-Zarishk, Arq mako and Arq Kasni) DOI Open Access

Zaffar Hussain,

Shugufta Hamid,

Nasir Nazir Wani

et al.

International Journal of Community Medicine and Public Health, Journal Year: 2025, Volume and Issue: 12(5), P. 2352 - 2355

Published: April 30, 2025

Non-alcoholic steatohepatitis is defined as the fat buildup of greater than 5 percent together with histologic indications necro-inflammation and hepatocyte ballooning degeneration. A 60-year-old female patient was diagnosed on 27/2/2024. She stable without any symptoms until she developed abdominal discomfort approached OPD, department Moalajat, RRIUM, Srinagar. a case NASH, which confirmed help fibro scan. The regression may have been due to anti-inflammatory, hepatoprotective, antioxidant, hypolipidemic, hypoglycemic effects drugs given patient. In addition this, also possess liver strengthening, demulcent diuretic add more their healing effects.

Language: Английский

Citations

0
基于红外光谱的龙葵不同部位α-茄碱分布特征研究 DOI

yan liu,

Minzhen Si

Published: Jan. 1, 2025

Citations

0
Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer DOI Creative Commons
Zhengde Wen,

Shan Luo,

Juntao Liu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4235 - 4255

Published: April 1, 2025

α-Solanine (α-Sol) shows promise for pancreatic cancer (PC) treatment by inhibiting PC cell proliferation, migration, and invasion. However, its clinical application is hindered poor tumor targeting, significant toxicity, undesirable pharmacokinetics. To address these issues, this study developed a nanoparticle delivery system (PBSO NPs) using bovine serum albumin as carrier, with polyallylamine hydrochloride surface modification to enhance α-Sol delivery. PBSO NPs were characterized transmission electron microscopy, dynamic light scattering, size analyzers, Fourier-transform infrared spectroscopy. Their in vitro drug release profile cellular uptake capabilities evaluated. Furthermore, experiments conducted mouse cells (Panc02) investigate the effects of on Panc02 viability, invasion, apoptosis. Additionally, xenograft model was established vivo explore impact growth. This successfully favorable morphology physiological stability, capable enhancing uptake. In demonstrated that significantly inhibited invasion while promoting Moreover, enhanced inhibitory cells. further confirmed improved therapeutic efficacy against partially reducing toxicity. exhibited good biocompatibility. apoptosis, thereby suppressing progression PC. provides promising strategy treatment.

Language: Английский

Citations

0
An Update on Antitumor Efficacy of Catechins: From Molecular Mechanisms to Clinical Applications DOI Creative Commons
Patrick Valère Tsouh Fokou, Boniface Pone Kamdem,

Regina Appiah‐Oppong

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT Carcinogenesis is the process by which substances that cause cancer (carcinogens) produce cancer. Extensive research conducted in recent years shows risk of developing certain cancers can be reduced eating a variety fruits and vegetables regularly. Catechins, are more prevalent foods beverages made from plants, known to have anti‐cancer effects. Detailed mechanistic studies helpful understanding inhibitory effects catechins on carcinogenesis providing background information for evaluating human carcinogenesis. This article provides an overview their potential roles prevention treatment, focusing how they alter signaling pathways, slow cell proliferation, trigger apoptosis. Also, this discusses molecular modifications epigallocatechin gallate as well delivery methods based nanostructures.

Language: Английский

Citations

0
A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties DOI Creative Commons

Nadia Zargarani,

Mahsa Kavousi, Elaheh Aliasgari

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 12, 2025

Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cell types. We synthesized optimized niosome NPs (NPs) with high solubility capacity for solanine loading. In this study, cytotoxic, cycle inhibitory apoptotic effects solanine-loaded (SN-NPs) on MCF-7 were investigated. Thin-layer hydration was used generate SN-NPs their features validated. The pH-dependent release pattern also examined. Synthesized evaluated cytotoxicity against MCF-10 lines using MTT. Primary secondary apoptosis, necrosis, arrest measured flowcytometry. Lastly, q-PCR assess genes. had an average size between 50 70 nm, a polydispersity index (PDI) 0.452. effectively incorporated into noisome NPs, as encapsulation efficiency 82.3%±0.24%. After quick burst at pH 7 5, released slowly sustainedly. IC50 niosomes cells decreased from 40 mg/100 mL 10 (48 h) 5 (72 h). 72 h, caused late 30% necrosis 5.06% (p < 0.01). 81% G0/G1 phase, only 12% progressing G2/M Solanine-loaded significantly increased Bax CDH-1 gene malignant compared free 0.0001). Bcl-2 MMP2 group 0.001). Solanine-containing showed significant anticancer breast cells, which supported regulation expression. regulated precise delivery show considerable translational potential. This improved nanocarrier technology may increase bioavailability efficacy solanine, potentially leading clinical outcomes therapy.

Language: Английский

Citations

0