A Traditional Gum Exudate From Pistacia atlantica Ameliorates Etha‐Nol‐Mediated Gastric Ulcer in Rats: Possible Molecular Mechanisms

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

Pistacia atlantica (Bene) is a native Mediterranean plant that exudates resinous therapeutic oleoresin gum used for many inflammatory-related diseases. Therefore, the present study evaluates acute toxicity and gastroprotective effects of (PAG) on ethanol-mediated gastric ulcers in rats. Sprague Dawley rats (30) were placed 5 cages: Group A received 10% tween 20; B, ulcer control, reference (C, 20 mg/kg omeprazole), groups D E 250 500 PAG, respectively. After 60 min, Groups B-E absolute ethanol (5 mL/kg). The results showed lack any physiological alterations supplemented with up to g/kg PAG. In trial, controls exhibited extensive mucosal injuries, reduced stomach mucus secretion, highly acidic stomach, increased lesion areas. Ethanol ingestion caused significant inflammatory cell infiltration oxidative stress indicators their tissues. revealed HSP 70, elevated Bax protein expressions, lowered antioxidant enzymes up-regulated MDA contents. PAG treatment restored these negative ethanol, which could be because its terpenoids, phenolics, flavonoids potentials positively modulated defense barriers (mucopolysaccharides), antioxidants, significantly pH cytokines (TNF-α IL-6). gastro-prophylactic are validated by modulatory actions mechanisms, providing scientific evidence future biochemical characterizations.

Language: Английский

The Gastroprotective Effects of Salvia indica L. and Selenium In Vivo Study

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский