Gadolinium Toxicity: Mechanisms, Clinical Manifestations, and Nanoparticle Role DOI
José L. Domingo

Published: April 29, 2025

Gadolinium-based contrast agents (GBCAs), essential for MRI, are facing renewed scrutiny due to gadolinium (Gd) retention and emerging toxicity profiles. While the link between less stable Nephrogenic Systemic Fibrosis (NSF) in renal impairment is established, deposition also observed brain, bone, skin across all GBCA classes, even patients with normal function. This finding has raised concerns led controversial concept of Gadolinium Deposition Disease (GDD). The present review synthesizes current evidence on clinical manifestations underlying mechanisms. It highlights pathways beyond traditional transmetallation, particularly endogenous nanoparticle formation as a key mechanism Gd release retention, potentially challenging stability assumptions macrocyclic agents. Structural factors (linear/macrocyclic; ionic/non-ionic) parameters (thermodynamic log K; kinetic kobs) influencing risk evaluated alongside regulatory responses. GBCAs should be viewed not inert diagnostics but complex, cumulative biological interactions. Future research focus developing non-gadolinium alternatives, validating biomarkers early detection conducting controlled trials chelation therapy efficacy. Clinicians must balance diagnostic benefits potential long-term risks, ensuring informed patient consent judicious use.

Language: Английский

Coiled coils as ligands for inclusion in the inorganic chemist's toolbox – For advances in MRI contrast agent design DOI
Anna F. A. Peacock

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 112903 - 112903

Published: March 1, 2025

Language: Английский

Citations

0
Sustainable and Eco-Friendly Nanomaterials DOI
Anita Restu Puji Raharjeng, Evika Sandi Savitri, Ruqiah Ganda Putri Panjaitan

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 143 - 180

Published: April 25, 2025

This book chapter elucidates key concepts such as the molecular mechanisms of life, biomolecular synthesis, bioenergetics, and chemical interactions within biological systems. integrated approach is designed to support a science curriculum that meets contemporary needs, emphasizing exploration real-world phenomena through laboratory experiments, digital simulations, cutting-edge technological applications. also highlights importance global issues climate change, waste management, public health in context biology chemistry. With research-driven methodology problem-based learning approaches, it offers practical guidance for educators, students, researchers effectively apply various academic industrial contexts. Through educational innovation cross-disciplinary integration, Molecular Revolution aims inspire transformation teaching learning, building strong foundation future generations address challenges with knowledge empathy.

Language: Английский

Citations

0
Gadolinium Toxicity: Mechanisms, Clinical Manifestations, and Nanoparticle Role DOI
José L. Domingo

Published: April 29, 2025

Gadolinium-based contrast agents (GBCAs), essential for MRI, are facing renewed scrutiny due to gadolinium (Gd) retention and emerging toxicity profiles. While the link between less stable Nephrogenic Systemic Fibrosis (NSF) in renal impairment is established, deposition also observed brain, bone, skin across all GBCA classes, even patients with normal function. This finding has raised concerns led controversial concept of Gadolinium Deposition Disease (GDD). The present review synthesizes current evidence on clinical manifestations underlying mechanisms. It highlights pathways beyond traditional transmetallation, particularly endogenous nanoparticle formation as a key mechanism Gd release retention, potentially challenging stability assumptions macrocyclic agents. Structural factors (linear/macrocyclic; ionic/non-ionic) parameters (thermodynamic log K; kinetic kobs) influencing risk evaluated alongside regulatory responses. GBCAs should be viewed not inert diagnostics but complex, cumulative biological interactions. Future research focus developing non-gadolinium alternatives, validating biomarkers early detection conducting controlled trials chelation therapy efficacy. Clinicians must balance diagnostic benefits potential long-term risks, ensuring informed patient consent judicious use.

Language: Английский

Citations

0