VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway DOI Creative Commons

Jingxin Cui,

Liwei Xu,

Yimeng Sun

et al.

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases brain injuries, often leading to neuronal damage death. Alleviating neuroinflammation has thus emerged as promising strategy protect neurons ameliorate disorders. While peroxisome proliferator-activated receptor gamma (PPARγ) agonists have demonstrated potential therapeutic actions on neuroinflammation, their prolonged use, such with rosiglitazone, can lead cardiac risks lipid differentiation In this study, we investigated effects newly synthesized PPARγ agonist, VSP-2, cytokines BV2 cells. Treatment VSP-2 significantly reduced mRNA protein levels proinflammatory interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α). Furthermore, attenuated phosphorylation nuclear factor kappa B (NF-κB) (65 kD) IκBα, well translocation NF-κB kD). Additionally, use small interfering RNA was able attenuate pathway. conclusion, our findings suggest that effectively suppressed expressions IL-1β, TNF-α via PPARγ/NF-κB signaling Given its benefits, may emerge candidate for treatment or injuries associated neuroinflammation.

Language: Английский

GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury DOI Creative Commons
Xin Zhang, Xinyu Liu, Qianxi Li

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317683 - e0317683

Published: Jan. 22, 2025

Motor dysfunction and muscle atrophy are typical symptoms of patients with spinal cord injury (SCI). Exercise training is a conventional physical therapy after SCI, but exercise intervention alone may have limited efficacy in reducing secondary promoting nerve regeneration functional remodeling. Our previous research found that intramedullary pressure SCI one the key factors affecting prognosis. It has been reported GsMTx-4, specific blocker mechanosensitive ion channels Piezo1, can protect integrity neuromuscular junction promote regeneration, thus potential as therapeutic agent for SCI. In this study, we observed combined separate effect GsMTx-4 on structure soleus motor function rats At 42 days post-injury, compared rats, Basso–Beattie–Bresnahan score (P = 0.0007) Gait Symmetry 0.0002) were significantly improved combination therapy. On histology rat muscle, treatment increased wet weight ratio, fiber cross-sectional area acetylcholinesterase (all P<0.0001). tissue, neuron counts BDNF levels, reduced percentage TUNEL-positive cells physiology succinate dehydrogenase expression (P<0.0001), while α-glycerophosphate (P<0.0001) GDF8 protein 0.0008) decreased. Results indicate effectively improves histopathology enhancing function. This study was conducted animal models, it offers insights treatment, advancing understanding lower limb pathology post-SCI. Further needed clinical validation future.

Language: Английский

Citations

0
Phellopterin Mitigates Cerebral Ischemia–Reperfusion Injury in Mice via NF-κB, COX-2 Inflammatory Pathway and OGD/R-Induced SH-SY5Y Cells DOI

W. K. Wu,

Y.-T. Wang

Revista Brasileira de Farmacognosia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Piezo1-related physiological and pathological processes in glioblastoma DOI Creative Commons
Weijia Fu,

Xue Hou,

Lijuan Ding

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 21, 2025

Glioblastoma (GBM) is the most malignant of astrocytomas, primarily involving cerebral hemispheres and cortex. It one fatal refractory solid tumors with a 5-year survival rate only 5% in adults. Cells biological tissues are subjected to mechanical forces, including hydrostatic pressure, shear stress, compression tension. can convert mechanomechanical signals into or electrical signals, process known as signaling. Piezo1 channels, members Piezo family mechanosensitive ion be directly activated by stimuli alone, mediating cation currents that activate subsequent signaling pathways. Studies have shown largely unexpressed normal brain but expressed at high levels glioblastoma significantly contribute development progression, its role pathogenesis remains unclear. We reviewed relevant literature data six major databases PubMed, EMBASE, CINAHL, Scopus, Web Science TCGA. Finally, total 126 papers were selected for review analysis (Search terms include: glioblastoma, piezo1, biomechanical, targeted therapy, mechanomechanical, extracellular matrix, radiation therapy more). The piezo1 was summarized. affects several fundamental pathophysiological processes such tissue sclerosis, angiogenesis, energy supply, immune cell infiltration, used an indicator malignancy prognosis patients well therapeutic target control tumor progression. pathological mechanism very complex, aberrant expression plays important glioblastoma. Specific mechanistic studies focusing on will help us understand mechanobiology develop new approaches patients.

Language: Английский

Citations

0
Mechanistic insights into the neuroprotective effects of low-intensity transcranial ultrasound stimulation in post-cardiac arrest brain injury: Modulation of the Piezo1-Dkk3/PI3K-Akt pathway DOI
Shuang Xu,

Lulu Gu,

Banghe Bao

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Multi-bioluminescence based dynamic imaging of Pseudomonas aeruginosa-induced hepatic inflammation process DOI
Xingzhao Liu, Yinghua Li,

Minwei He

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107521 - 107521

Published: March 1, 2025

Language: Английский

Citations

0
TRIM22 governs tumorigenesis and protects against endometrial cancer-associated cachexia by inhibiting inflammatory response and adipose thermogenic activity DOI Creative Commons
Ping Zhang,

Quanrong Li,

Min Wu

et al.

Cancer & Metabolism, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 8, 2025

Language: Английский

Citations

0
Piezo1 in microglial cells: Implications for neuroinflammation and tumorigenesis DOI Creative Commons
Bo Yang, Zhenyu Li, Peiliang Li

et al.

Channels, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 13, 2025

Microglia, the central nervous system (CNS) resident immune cells, are pivotal in regulating neurodevelopment, maintaining neural homeostasis, and mediating neuroinflammatory responses. Recent research has highlighted importance of mechanotransduction, process by which cells convert mechanical stimuli into biochemical signals, microglial activity. Among various mechanosensitive channels, Piezo1 emerged as a key player microglia, influencing their behavior under both physiological pathological conditions. This review focuses on expression role particularly context neuroinflammation tumorigenesis. We explore how mediates responses to changes within CNS, such alterations tissue stiffness fluid shear stress, common conditions like multiple sclerosis, Alzheimer's disease, cerebral ischemia, gliomas. The also discusses potential targeting for therapeutic intervention, given its involvement modulation activity impact disease progression. integrates findings from recent studies provide comprehensive overview Piezo1's mechanistic pathways function. These insights illuminate new possibilities developing targeted therapies addressing CNS disorders with mechanics.

Language: Английский

Citations

0
Arjunolic acid from Rhodomyrtus tomentosa Suppresses Growth of Non-Small Cell Lung Cancer via Inducing Autophagy and Apoptosis DOI Creative Commons

Ziying Huang,

Chang Liu, Chenchen Zhang

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100616 - 100616

Published: April 1, 2025

Language: Английский

Citations

0
ω3-PUFA alleviates neuroinflammation by upregulating miR-107 targeting PIEZO1/NFκB p65 DOI
Hailin Liu, Lian Zhou, Pengcheng Yi

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111996 - 111996

Published: April 4, 2024

Language: Английский

Citations

3
Piezo1 is a Pathogenic Gene and Therapeutic Target for Neurological Diseases DOI
Hui Wang,

Zhixian Gou,

Shunrui Chen

et al.

International Journal of Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 23

Published: April 25, 2025

Piezo1 is a ubiquitously expressed non-selective cation channel protein found across various species. It possesses the ability to detect and respond external mechanical forces, converting cues into intracellular bioelectrical events, thereby facilitating propagation of electrochemical signals. Within nervous system, integral synaptogenesis myelination, modulation pro-inflammatory mediators, neuropathic pain, cognitive processes, angiogenesis, regulation cerebral hemodynamics, consequently impacting pathogenesis progression neurological disorders. This review meticulously summarizes synthesizes existing literature provide an exhaustive overview Piezo1's roles mechanisms in spectrum diseases, including neurodegenerative disorders, cerebrovascular accidents, traumatic brain injuries, gliomas, multiple sclerosis, epilepsy. Additionally, it explores potential therapeutic applications targeting Piezo1. The discussion also encompasses current research limitations, imperative need for future investigations, prospective strategies. Our analysis indicates that susceptibility gene conditions, its expression inhibition may confer benefits. In summary, this comprehensive offers novel insights involvement diseases establishes theoretical groundwork development Piezo1-targeted interventions.

Language: Английский

Citations

0