Role of the integrated stress response system (ISR) in neuropsychiatric pathologies of the central nervous system DOI
Nikita P. Ilyin, V. S. Nikitin, Allan V. Kalueff

et al.

Журнал эволюционной биохимии и физиологии, Journal Year: 2024, Volume and Issue: 60(6)

Published: Nov. 15, 2024

Language: Английский

Reduced White Matter Damage and Lower Neuroinflammatory Potential of Microglia and Macrophages in Hri/Eif2ak1−/− Mice After Contusive Spinal Cord Injury DOI Open Access
Sujata Saraswat Ohri,

Scott A. Myers,

Benjamin Rood

et al.

Glia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Cellular stressors inhibit general protein synthesis while upregulating stress response transcripts and/or proteins. Phosphorylation of the translation factor eIF2α by one several stress-activated kinases is a trigger for such signaling, known as integrated (ISR). The ISR regulates cell survival and function under stress. Here, germline knockout mice were used to determine contributions three major kinases, HRI/EIF2AK1, GCN2/EIF2AK4, PKR//EIF2AK2, pathogenesis moderate contusive spinal cord injury (SCI) at thoracic T9 level. One-day post-injury (dpi), reduced levels peIF2α found in Hri

Language: Английский

Citations

0
The Role of the Integrated Stress Response (ISR) in Neuropsychiatric Disorders DOI
Nikita P. Ilyin, V. S. Nikitin, Allan V. Kalueff

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(6), P. 2215 - 2240

Published: Nov. 1, 2024

Language: Английский

Citations

0
Role of the integrated stress response system (ISR) in neuropsychiatric pathologies of the central nervous system DOI
Nikita P. Ilyin, V. S. Nikitin, Allan V. Kalueff

et al.

Журнал эволюционной биохимии и физиологии, Journal Year: 2024, Volume and Issue: 60(6)

Published: Nov. 15, 2024

Language: Английский

Citations

0